Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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$140K - $165K *

Join a team that's redefining healthcare technology by owning the product roadmap, translating company goals into actionable tasks, and ensuring seamless delivery of AI-driven solutions that enhance p...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$88K *

Advance the prosecution of criminal cases in Woodbury County, ensuring justice through effective legal representation, case preparation, and courtroom advocacy while collaborating with law enforcement...

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$120K - $250K *

Transform clinical trials by ensuring patient safety and scientific integrity. Collaborate with stakeholders to uphold regulatory standards and optimize study protocols, while providing expert medical...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$220K - $300K *

Shape the future of financial strategy by leading comprehensive reporting, planning, and analysis. Collaborate with cross-functional teams to enhance decision-making and drive performance, while ensur...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$152K - $229K *

Lead the charge in data governance for clinical trials, ensuring compliance and quality. Collaborate with cross-functional teams to implement data standards and frameworks, enhancing the value of stat...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$138K - $172K *

Empower revenue teams as a Senior Business Systems Analyst, driving efficiency through Salesforce architecture, process design, and actionable data across GTM, Marketing, Sales, and Customer Success o...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$165K - $200K *

Transform captive program management by driving portfolio growth, enhancing underwriting practices, and fostering strong partner relationships. Join a dynamic team to shape innovative solutions and de...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $115K *

Elevate your career by managing a diverse loan portfolio, driving growth, and ensuring compliance. Lead a team while developing lending strategies and fostering client relationships in a dynamic finan...

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$104K - $174K *

Champion the development of sales professionals by designing and delivering impactful training programs. Collaborate with leadership to enhance skills, knowledge, and effectiveness, ensuring a consist...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$160K - $200K *

Lead the charge in providing tailored financial planning and investment strategies for senior executives. Collaborate with a dedicated team to enhance client relationships and drive business growth wh...

RemoteRemote

6 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$82K - $153K *

Unlock potential by driving acquisition strategies and building relationships with agency owners. Collaborate with leadership to enhance deal pipelines and support growth initiatives through effective...

RemoteRemote

6 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Elevate your career by partnering with clients to enhance FP&A processes, build financial models, and drive operational improvements in a dynamic Private Equity environment. Collaborate with teams to...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$127K - $171K *

Elevate risk management practices by collaborating with business leaders to implement strategies that align with corporate objectives, assess risks, and enhance control environments, ensuring effectiv...

6 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$127K - $171K *

Engage with our Enterprise Risk Management team to enhance risk practices across business functions. As a trusted advisor, you'll lead initiatives, assess risks, and influence strategies to balance ri...

Des Moines, IARemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$120K - $145K *

Join a team that's advancing oncology solutions by managing global clinical trials. Lead project execution from protocol development to study closeout, ensuring quality and compliance while fostering...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$85K - $100K *

Unlock potential by driving sales in a high-demand market. Engage with homeowners, generate leads, and close deals to maximize your earnings. Join a results-driven team where your skills directly impa...

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$180K - $220K *

Lead the development and execution of global government affairs strategies, fostering relationships with key stakeholders and providing strategic counsel on policy and regulatory matters impacting the...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$100K - $160K *

Lead critical evaluations of biological risks, mentor junior specialists, and ensure high-quality labeling for AI safety classifiers in a dynamic life-sciences environment focused on biodefense and bi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$90K - $110K *

Help us elevate our claims process by managing litigated files, negotiating settlements, and collaborating with teams to enhance technology and processes. Your expertise will drive effective resolutio...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Champion client success by leading complex commercial real estate projects, managing multi-site portfolios, and providing senior technical expertise to multidisciplinary teams, ensuring effective deli...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$120K - $150K *

Join a team that's shaping the future of consulting in P&C insurance. Lead client engagements, ensure quality standards, and foster long-term relationships while driving business growth and mentoring...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$260K - $300K *

Partner with us to ensure our products meet legal standards while fostering innovation. Collaborate with cross-functional teams throughout the product lifecycle, from design to launch, enabling respon...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Transform partner relationships into measurable success by managing a strategic portfolio of technology and advisory partners. Collaborate across teams to drive growth, co-sell, and enhance operationa...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$186K - $233K *

Pioneer innovative strategies in breast oncology, driving commercial success through collaboration and data-driven insights. Lead cross-functional teams to enhance product adoption and optimize market...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Help us drive revenue growth by developing strategic sales plans and building executive partnerships in the mortgage servicing industry. Leverage your expertise to manage complex sales cycles and enha...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.