Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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$100K - $120K *

Drive client success by enhancing revenue cycle performance and fostering strategic relationships with enterprise clients. Leverage expertise to implement solutions, manage risks, and ensure measurabl...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Healthcare

$76K - $148K *

Play a key role in managing clinical trials, ensuring compliance and quality oversight of project deliverables while collaborating with cross-functional teams to meet timelines and budget goals...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$157K - $212K *

Lead the charge in enhancing AI search functionality, empowering legal professionals to seamlessly find documents. Collaborate with engineering teams to optimize search relevance, performance, and use...

RemoteRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$116K - $157K *

Grow your career with our FP&A Systems team, designing innovative EPM solutions and enhancing financial planning processes. Collaborate with various stakeholders to optimize efficiency and ensure data...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$80K - $95K *

Empower the clinical support team by coordinating complex cases, mentoring junior counselors, and enhancing protocols. Your expertise will drive effective communication and quality standards in geneti...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Transform your career by leading compliance assurance initiatives that enhance the reliability of the North American electric grid. Collaborate with industry stakeholders to develop and implement risk...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$237K - $296K *

Join a team that's driving innovation in oncology by leading clinical development and medical affairs. Collaborate across functions to advance pivotal programs and ensure operational excellence in a f...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead the charge in managing complex clinical trials, ensuring timely delivery, budget adherence, and high-quality outcomes while collaborating with multidisciplinary teams and stakeholders to enhance...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $120K *

Unlock potential by conducting thorough MLR examinations, ensuring compliance with federal and state regulations. Collaborate with teams to analyze data, review documentation, and enhance audit proced...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$99K - $110K *

Lead the preparation and delivery of tax returns for ultra-high-net-worth clients. Enjoy a supportive environment with no billable hours, focusing on client service and tax compliance while benefiting...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$125K - $135K *

Join a team that's driving growth in the life insurance and annuity market. Leverage your expertise to build strategic relationships, manage the full client lifecycle, and align solutions with client...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$160K - $180K *

Provide oversight for insurance accounting and reporting, driving process improvements and leveraging technology to enhance financial operations. Collaborate with teams to ensure compliance and accura...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Finance & Insurance

$176K - $281K *

Empower your career by leading complex service portfolios, driving strategic initiatives, and delivering measurable value through innovative solutions in a dynamic environment. Collaborate across team...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$150K - $250K *

Unlock revenue growth by leading a dynamic sales organization, driving enterprise strategies, and fostering collaboration across teams to achieve sustainable success in a high-growth environment...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $95K *

Lead the charge in managing site operations and vendor relations, ensuring compliance and efficiency in clinical research projects. Collaborate with teams to streamline processes and enhance training...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$84K - $124K *

Join us to lead the acquisition and management of right of way agreements for fiber optic projects across North America, collaborating with stakeholders to ensure compliance and successful negotiation...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$110K - $130K *

Champion your career by leading security engagements, assessing architectures, and enhancing compliance. Collaborate with top professionals to identify risks and implement best practices, ensuring rob...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $100K *

Empower client success by managing portfolios, ensuring operational efficiency, and supporting Client Managers. Develop essential skills in data accuracy and communication while contributing to high c...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Finance & Insurance

$195K - $225K *

Lead the charge in transforming client development through strategic operations and enablement. Drive growth initiatives, manage a high-performing team, and ensure seamless execution across programs t...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$85K - $120K *

Lead the charge in regulatory affairs by providing strategic guidance, ensuring compliance, and fostering collaboration across institutions. Drive initiatives from research to implementation while men...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$85K - $106K *

Empower clients by leading innovative paid search strategies across diverse categories. Collaborate with cross-functional teams to drive performance, optimize campaigns, and connect search tactics to...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$110K *

Take ownership of complex mortgage loan evaluations, ensuring compliance with guidelines while assessing borrower risk. Collaborate with internal teams and vendors to facilitate loan approvals and mai...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$80K - $100K *

Empower your career by analyzing complex claims in a dynamic environment. Collaborate with industry leaders to deliver innovative solutions while enjoying flexibility and professional growth opportuni...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$116K - $216K *

Lead a team in assessing credit risk through comprehensive reviews, ensuring compliance and quality in loan portfolios. Drive insights and improvements while collaborating with stakeholders to enhance...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $180K *

Transform the agent experience by leading strategy across recruitment, onboarding, and ongoing support. Drive engagement and success through cohesive learning and development initiatives, ensuring age...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.