Welcome to Principal Scientist Jobs

Grasp unique opportunities in the scientific realm by exploring high-paying Principal Scientist jobs that offer annual remuneration of over $100,000. Broaden your professional horizons and get closer to your career goals with our advanced search tools for Principal Scientists.

Why Principal Scientist Jobs?

As a Principal Scientist, you will lead innovation, drive scientific research, and contribute to the growth of the scientific community at large. It is a role that combines leadership, in-depth scientific knowledge, and impactful decision-making.

Our Offerings

We provide comprehensive job listings, insightful articles, growth opportunities, and a diverse range of resources for Principal Scientists looking to make their next career move.

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$176K - $277K *

Elevate the discovery landscape as you lead Nonclinical Drug Safety strategies across multiple therapeutic areas. Collaborate cross-functionally to assess risks, define toxicology study strategies, an...

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$176K - $277K *

Join a team that's dedicated to advancing innovative drug development through collaboration, leadership, and strategic vision in nonclinical safety across multiple therapeutic areas, ensuring patient...

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$117K - $184K *

Discover innovative solutions as a Senior Scientist, advancing biotherapeutics by leveraging deep expertise in biophysical characterization while collaborating cross-functionally to enhance drug quali...

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$78K - $116K *

Drive quality improvement initiatives by managing testing and troubleshooting of protein-based immunoassays. Collaborate with cross-functional teams to enhance product and process quality through data...

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$201K - $373K *

Advance research initiatives by developing innovative algorithms and frameworks in generative modeling. Collaborate with teams to publish findings, design experiments, and elevate machine learning met...

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$192K - $357K *

Advance foundational machine learning research by developing algorithms and frameworks. Collaborate in a flat scientific structure where senior scientists lead. Engage in open science and contribute t...

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$116K - $177K *

Lead the charge in bioanalytical studies, overseeing multiple projects and ensuring compliance with regulatory standards while mentoring team members in a fast-paced laboratory environment...

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$147K - $191K *

Drive innovative solutions by leading computational biology strategies, collaborating with cross-functional teams to advance projects from initial validation through regulatory studies, and managing b...

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$124K - $174K *

Shape the future of dermocosmetics by leading a dynamic R&D team to innovate professional skin care products. Collaborate cross-functionally to deliver effective formulations tailored for aesthetic an...

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$157K - $196K *

Elevate your career by leading innovative cfDNA assay developments in a dynamic R&D environment. Collaborate across functions to drive projects and enhance Natera's cutting-edge product portfolio whil...

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$204K - $385K *

Lead the design and implementation of control protocols to enhance AI safety through empirical research and experimentation, shaping innovative monitoring systems for coding agents in production envir...

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$128K - $210K *

Join our dynamic team to design and lead innovative experiments in genetic medicines targeting CNS disorders, working collaboratively to drive preclinical development and contribute to impactful thera...

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$159K - $200K *

Lead the development of PMO and modified ASO oligonucleotides, ensuring efficient manufacturing and regulatory compliance. Collaborate with internal teams and CDMOs to drive strategies that optimize p...

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Shape the future of quality assurance by driving enhancements in laboratory processes, ensuring compliance with specifications, and collaborating across departments to elevate product standards and re...

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$200K - $300K *

Lead the charge in advancing human health solutions through cutting-edge toxicological evaluations, strategic consulting, and risk assessments for diverse client sectors, driving impactful insights an...

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Champion innovative biological technologies to safely control insect populations. Lead and inspire a multidisciplinary team while managing research projects and ensuring compliance with safety standar...

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$72K - $89K *

Advance laboratory operations by performing tests, maintaining equipment, and ensuring quality control. Lead validation efforts and engage with customers. Drive process improvements and support a safe...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Lead collaborative initiatives in infectious disease research by implementing strategic actions, managing projects, and fostering communication across diverse scientific teams to drive impactful outco...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$119K - $170K *

Shape the future of cell therapy by leading drug product readiness and formulation optimization, ensuring regulatory compliance, and driving successful commercialization through innovative process dev...

Reposted today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$145K - $185K *

Lead the R&D efforts for innovative refrigerants and thermal solutions for mobile air conditioning and EV heat pump systems. Collaborate cross-functionally and engage with industry stakeholders to adv...

Today

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Drive environmental compliance and innovative solutions by conducting site assessments and developing remediation strategies, while leading project phases and mentoring junior staff within a dynamic t...

6 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$109K - $174K *

Drive the development of innovative enzyme formulations for DNA template manufacturing, ensuring stability and performance. Collaborate closely with cross-functional teams to translate scientific need...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$155K - $160K *

Transform analytical capabilities in a biotech firm by executing complex QC assays and ensuring reliable product consistency. Collaborate cross-functionally while leading training initiatives and refi...

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$109K - $179K *

Lead the charge in applying innovative mammalian expression technologies to generate stable cell lines while collaborating across teams and managing complex projects in a fast-paced environment...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$140K - $154K *

Join our team to apply engineering principles in innovative security solutions. Collaborate with cross-functional experts to enhance product quality and reliability through rigorous testing and analys...

3 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

Frequently Asked Questions (FAQ)

  • What is the role of a Principal Scientist?question toggle

    A Principal Scientist typically leads scientific research, explores innovative ideas, and guides a team of scientists towards achieving the organization's scientific goals.

  • How much does a Principal Scientist earn on average?question toggle

    The average salary of a Principal Scientist varies depending on the industry and level of experience. However, on Ladders, you can find Principal Scientists jobs that pay over $100,000.

  • What qualifications are required for Principal Scientist jobs?question toggle

    Most Principal Scientist roles require at least a Ph.D. in a relevant scientific field along with several years of research experience. Leadership skills and a proven research track record are typically also essential.

  • Can I find remote Principal Scientist jobs on Ladders?question toggle

    Yes, on Ladders, you can find both remote and in-office high-paying Principal Scientist jobs.