Explore Principal Scientist jobs on Ladders, where professionals can find vetted opportunities paying $100,000 or more. Principal Scientists lead complex research, guide scientific strategy, and turn deep technical expertise into discoveries, products, and business impact.
Principal Scientists provide senior-level scientific direction within organizations such as biotechnology and pharmaceutical companies, healthcare organizations, technology firms, manufacturers, and research institutions. They design and oversee research programs, interpret complex data, develop new methods, and communicate findings to technical and executive stakeholders. Depending on the organization, they may also mentor scientists, manage collaborations, and help set long-term research priorities.
Employers typically seek extensive experience in a relevant scientific discipline, a strong record of research or technical achievement, and the ability to lead projects across teams. Commonly valued skills include experimental design, data analysis, scientific writing, subject-matter expertise, project leadership, and clear communication. Many positions require a Ph.D. or other advanced degree, though requirements vary by field and employer.
Compensation varies based on specialty, experience, location, and employer. Ladders focuses on vetted professional opportunities paying at least $100,000, making it a useful place to explore senior-level Principal Scientist roles. Career paths may lead to scientific leadership, research director, vice president of research, or other executive and technical leadership positions.
Search Principal Scientist openings by specialty, location, and other preferences to identify roles aligned with your experience. Review each listing for its responsibilities, qualifications, and compensation details, then apply directly to opportunities that match your career goals.
$103K - $176K *
Innovate solutions by leading mechanical engineering projects to enhance production processes. Collaborate with stakeholders to design, implement, and optimize equipment and systems, ensuring safety a...
2 weeks ago
Director, Sourcing & Procurement
$190K - $237K *
Optimize sourcing strategies and procurement processes for clinical operations, ensuring effective vendor management and governance across global clinical trials. Collaborate with cross-functional tea...
3 weeks ago
Director, Customer Solutions – Navy
$190K - $200K *
Manage strategic customer engagement and growth within Navy and DoD sectors. Leverage existing networks and industry insights to identify business opportunities that align with Millennium’s objectives...
Reposted today
Principal Engineer Team Lead, Simulation Infrastructure
$200K - $275K *
Lead and optimize cloud infrastructure for simulation frameworks, driving team performance and technical strategy. Collaborate cross-functionally to enhance validation processes and ensure robust soft...
Reposted 2 weeks ago
Principal Engineer - Reporting & Insights
$287K - $320K *
Join a team that's redefining financial insights through AI. As a senior technical leader, you'll shape the multi-year strategy for Reporting & Insights, guiding engineering teams to innovate and scal...
2 weeks ago
Vaccines Specialist, Health and Science Professional - Ocala, FL
$76K - $199K *
Advance customer engagement and sales strategies for a Vaccines Portfolio, driving product promotion and relationship development through both in-person and virtual interactions while collaborating wi...
1 week ago
$110K - $130K *
Elevate your career by architecting scalable analytics systems and AI-driven workflows that empower decision-making across our enterprise SaaS business, paving the way for innovation and growth in a d...
Reposted 1 week ago
Staff Engineer, Software - GenAI
$126K - $215K *
Transform AI experiences by architecting LLM-based agents that integrate with real-world tools, orchestrate tasks, and scale in production. Collaborate across teams to drive innovation and ensure high...
3 weeks ago
$120K - $145K *
Champion impactful programs by leading cross-functional teams, driving strategic alignment, and ensuring seamless execution. Leverage your expertise to manage complex initiatives that delight customer...
2 weeks ago
Senior Manager, Clinical Trial Disclosure & Transparency
$132K - $199K *
Join a team that's committed to transparency in clinical trials, ensuring compliance with global disclosure regulations. This role blends operational and strategic tasks, fostering collaboration and q...
3 weeks ago
VP, Labor & Public Sector Sales
$215K - $250K *
Pioneer your career by leading a dynamic sales team focused on Labor and Public Sector markets. Drive growth, mentor talent, and execute strategic initiatives to exceed revenue goals while building im...
3 weeks ago
Senior AI Engineer (CCC Casualty / Claims Intelligence)
$180K - $225K *
Transform the future of auto claims by designing AI agents that enhance decision-making and streamline processes. Join a dynamic team to build innovative solutions that improve efficiency and accuracy...
2 days ago
$146K - $170K *
Lead the charge in enhancing client relationships and driving growth across our North American laboratory network. Oversee Client Service teams, ensuring seamless service delivery and proactive accoun...
Today
Senior Marketing Manager - Narrative and Launch
$135K - $165K *
Transform the marketing landscape by driving product launches, shaping narratives, and executing strategies in a dynamic environment. Collaborate closely with engineers to communicate complex technolo...
Reposted 3 days ago
$130K - $180K *
Build a robust data foundation to elevate Market Intelligence. Drive automation and streamline data workflows, enriching insights for research and publishing, while ensuring data integrity and accessi...
Reposted 3 weeks ago
Staff Product Engineer, Developer Experience
$135K - $160K *
Engage with engineers to enhance developer workflows and tools. Own the product lifecycle from discovery to adoption, ensuring high-quality internal software that meets user needs and drives efficienc...
3 weeks ago
$127K - $190K *
Drive innovative optical solutions in semiconductor metrology. Collaborate with cross-functional teams to design, prototype, and optimize optical systems, ensuring customer satisfaction and alignment...
3 days ago
$160K - $200K *
Unlock potential by leading AI/ML R&D efforts, driving model evaluation, predictive analytics, and experimental design while mentoring a team to enhance organizational ML fluency and deliver measurabl...
Today
$70K - $115K *
Empower your career by joining a dynamic team focused on healthcare compliance auditing. Utilize your analytical skills to drive impactful audits and contribute to client deliverables while receiving...
2 weeks ago
Senior Director, Product Management, Agentic Platform
$192K - $303K *
Empower innovation as you lead the strategy and development of core platform primitives, driving the future of agentic systems and ensuring product teams can rapidly create and deploy advanced agents...
4 weeks ago
Associate Medical Director - Market Access Marketing
$110K - $145K *
Elevate medical communications by developing high-quality, strategic content across therapeutic areas. Collaborate with teams and clients to ensure accuracy and adherence to guidelines while supervisi...
Yesterday
$90K - $120K *
Transform media operations by planning and coordinating across various areas, ensuring efficiency and adherence to best practices while driving productivity and cost savings in a dynamic environment...
1 week ago
Sr. Account Director, Business Development (Biotech CDSD) - US East Coast
$110K - $130K *
Empower growth by orchestrating RFP strategies, developing proposals, and closing contracts. Engage with biotech clients to ensure satisfaction and drive sales success through effective communication...
Today
$110K - $120K *
Drive the financial health of projects while leading teams to success. Manage budgets, forecasts, and vendor coordination to ensure project delivery across multiple brands. Your strategic insight will...
3 weeks ago
Senior Product Marketing Manager (US)
$120K - $145K *
Unlock potential by leading product marketing strategies for developer-facing solutions. Collaborate across teams to enhance messaging, drive customer engagement, and ensure successful deployments, al...
1 week ago
What does a Principal Scientist do?
A Principal Scientist leads advanced research or technical programs, sets scientific direction, analyzes results, and shares findings with stakeholders. Responsibilities may also include mentoring colleagues and coordinating cross-functional teams.
What qualifications are commonly required for Principal Scientist jobs?
Requirements vary by specialty, but employers often look for extensive relevant experience, a strong record of scientific or technical work, and advanced expertise. Many roles require a Ph.D. or another advanced degree, along with research leadership and communication skills.
How much do Principal Scientists earn?
Pay depends on factors such as field, location, experience, and employer. Ladders features vetted professional jobs paying $100,000 or more; check individual listings for compensation information.
Where do Principal Scientists work?
Principal Scientists work across industries including biotechnology, pharmaceuticals, healthcare, technology, manufacturing, and academic or independent research.
How can I find Principal Scientist jobs on Ladders?
Browse Principal Scientist listings on Ladders and use available search filters to narrow opportunities by location, specialty, or other preferences. Review each listing for its requirements and compensation details.