Explore Principal Scientist jobs on Ladders, where professionals can find vetted opportunities paying $100,000 or more. Principal Scientists lead complex research, guide scientific strategy, and turn deep technical expertise into discoveries, products, and business impact.
Principal Scientists provide senior-level scientific direction within organizations such as biotechnology and pharmaceutical companies, healthcare organizations, technology firms, manufacturers, and research institutions. They design and oversee research programs, interpret complex data, develop new methods, and communicate findings to technical and executive stakeholders. Depending on the organization, they may also mentor scientists, manage collaborations, and help set long-term research priorities.
Employers typically seek extensive experience in a relevant scientific discipline, a strong record of research or technical achievement, and the ability to lead projects across teams. Commonly valued skills include experimental design, data analysis, scientific writing, subject-matter expertise, project leadership, and clear communication. Many positions require a Ph.D. or other advanced degree, though requirements vary by field and employer.
Compensation varies based on specialty, experience, location, and employer. Ladders focuses on vetted professional opportunities paying at least $100,000, making it a useful place to explore senior-level Principal Scientist roles. Career paths may lead to scientific leadership, research director, vice president of research, or other executive and technical leadership positions.
Search Principal Scientist openings by specialty, location, and other preferences to identify roles aligned with your experience. Review each listing for its responsibilities, qualifications, and compensation details, then apply directly to opportunities that match your career goals.
Senior Technical Program Manager, Infrastructure Programs
$130K - $170K *
Execute end-to-end digital onboarding of complex AI data center infrastructure, managing cross-functional teams to ensure timely delivery, stability, and optimization of high-performance systems for p...
Reposted 2 weeks ago
Director - Data, Analytics & AI
$160K - $175K *
Elevate your career by leading data, analytics, and AI initiatives that drive strategic decision-making and operational excellence. Shape the future of our data ecosystem while collaborating with seni...
3 weeks ago
Director, Advanced Network Planning
$154K - $246K *
Join a dynamic team to lead advanced network planning initiatives, guiding strategic projects and shaping product roadmaps. Leverage your expertise to drive innovation in network optimization and ment...
4 weeks ago
Associate Director, Social Media
$90K - $115K *
Elevate your career by leading innovative social media programs that connect healthcare clients with their audiences. Drive strategic content development and manage cross-functional teams to ensure im...
Reposted 3 weeks ago
Director, Global Corporate Accounts
$163K - $239K *
Join us to drive strategic growth and profitability for key corporate accounts. Collaborate with cross-functional teams to develop innovative solutions, establish pricing policies, and cultivate long...
3 weeks ago
$148K - $210K *
Join us to lead and grow the power engineering team, managing high-level projects in substation design and grid integration. Drive technical excellence and strategic initiatives while shaping our serv...
Reposted today
Senior Director, Global Compensation
$233K - $500K+*
Lead the development and execution of innovative global compensation strategies, partnering with stakeholders to enhance employee engagement while ensuring compliance and effectiveness in a dynamic ma...
Reposted 3 days ago
CSD Diagnostic Partner - Business Development
$118K - $178K *
Lead the charge in Oncology companion diagnostics business development, collaborating globally to implement strategies that enhance market penetration and drive growth in the biopharmaceutical sector...
Reposted 1 week ago
Director, Quality Engineering, Primary Care
$156K - $215K *
Unlock your potential by leading quality engineering initiatives across diverse technology portfolios. Drive automation, enhance delivery quality, and foster team growth while collaborating with cross...
Reposted 1 week ago
Senior Principal Implementation Consultant
$100K - $185K *
Empower clients by leveraging deep ONESOURCE Direct Tax expertise to design innovative solutions using AI and automation tools. Engage directly with customers, manage projects, and drive efficiency wh...
2 weeks ago
Director, Continuous Improvement
$170K - $220K *
Lead continuous improvement initiatives across QSR operations, driving cultural transformation and operational excellence. Manage CI strategies, develop leaders, and ensure alignment with enterprise g...
4 weeks ago
Senior Manager - Technical Implementation & Value Realization
$135K - $150K *
Advance your career by leading complex enterprise implementations, driving customer adoption, and ensuring measurable value realization. Collaborate with cross-functional teams to operationalize solut...
4 weeks ago
$250K - $300K *
Empower the future of AI in commerce media by leading strategy and execution across AI Labs and Data Science. Drive customer engagement, scale capabilities, and enhance product impact while building a...
Reposted 6 days ago
$69K - $117K *
Serve as a vital link to customers by developing relationships and providing tailored solutions. Leverage sales strategies and insights to enhance customer satisfaction and drive growth, while collabo...
Reposted yesterday
$150K - $215K *
Lead the charge in driving enterprise sales for strategic consulting accounts, coaching a team of Account Executives while managing complex sales cycles. Build executive relationships and execute grow...
3 weeks ago
$120K - $140K *
Champion supply chain excellence by leading procurement activities for construction projects, ensuring alignment with schedules, budgets, and quality standards while mentoring specialists and driving...
Today
Senior Executive Talent Partner
$111K - $207K *
Empower growth by shaping executive talent strategies that drive success. Partner with senior leaders to enhance recruitment processes, develop talent pipelines, and advise on market trends, while ens...
Reposted 2 weeks ago
$110K - $130K *
Lead the IT workstream in executing complex business separations and transformations, managing cross-functional teams, and coordinating critical activities to ensure successful outcomes in a dynamic e...
Reposted 1 week ago
Senior Manager, Partner Technology Architecture
$202K - $334K *
Lead the charge in developing a high-performing team of Partner Technology Architects, driving partner growth through technical excellence, solution strategy, and AI adoption while ensuring impactful...
2 weeks ago
Senior Principal Solutions Architect (Federal Civilian Growth)
$200K - $250K *
Join us in shaping technical strategies and growth initiatives for federal opportunities. Collaborate across teams to develop compelling solutions that drive success in complex pursuits, ensuring alig...
Reposted 2 days ago
Director, AI ML and Cloud Security
$168K - $281K *
Architect cutting-edge AI solutions as the design authority for Cyber Architecture. Lead a team of architects to define agentic frameworks and data fabric, ensuring robust AI/ML implementations across...
3 days ago
Senior Director, Risk & Compliance Business Partners R&D
$195K - $325K *
Elevate the Risk & Compliance strategy for R&D, leading a team to foster a risk-aware culture, manage budgets, and engage with stakeholders to ensure effective cyber risk management across GSK's resea...
Reposted 1 week ago
$110K - $130K *
Elevate software solutions by designing and developing applications that enhance genetic testing workflows. Collaborate with cross-functional teams to ensure reliability and efficiency in clinical dia...
Today
$110K - $166K *
Optimize site contract management by reviewing, drafting, and negotiating various legal agreements. Collaborate with clinical teams to ensure timely deliverables and serve as a subject matter expert i...
1 week ago
Site Reliability Engineering Manager
$114K - $190K *
Build a resilient Site Reliability Engineering practice, leading a global team to enhance cloud platform reliability, scalability, and operational excellence while fostering collaboration and continuo...
3 weeks ago
What does a Principal Scientist do?
A Principal Scientist leads advanced research or technical programs, sets scientific direction, analyzes results, and shares findings with stakeholders. Responsibilities may also include mentoring colleagues and coordinating cross-functional teams.
What qualifications are commonly required for Principal Scientist jobs?
Requirements vary by specialty, but employers often look for extensive relevant experience, a strong record of scientific or technical work, and advanced expertise. Many roles require a Ph.D. or another advanced degree, along with research leadership and communication skills.
How much do Principal Scientists earn?
Pay depends on factors such as field, location, experience, and employer. Ladders features vetted professional jobs paying $100,000 or more; check individual listings for compensation information.
Where do Principal Scientists work?
Principal Scientists work across industries including biotechnology, pharmaceuticals, healthcare, technology, manufacturing, and academic or independent research.
How can I find Principal Scientist jobs on Ladders?
Browse Principal Scientist listings on Ladders and use available search filters to narrow opportunities by location, specialty, or other preferences. Review each listing for its requirements and compensation details.