Grasp unique opportunities in the scientific realm by exploring high-paying Principal Scientist jobs that offer annual remuneration of over $100,000. Broaden your professional horizons and get closer to your career goals with our advanced search tools for Principal Scientists.
As a Principal Scientist, you will lead innovation, drive scientific research, and contribute to the growth of the scientific community at large. It is a role that combines leadership, in-depth scientific knowledge, and impactful decision-making.
We provide comprehensive job listings, insightful articles, growth opportunities, and a diverse range of resources for Principal Scientists looking to make their next career move.
Principal Scientist, Process Engineering
$110K - $130K *
Execute and lead scientific research in drug formulation and delivery for protein-based therapeutics. Collaborate with cross-functional teams to design, develop, and optimize manufacturing processes...
Today
Principal Development Scientist
$100K - $130K *
Manage the design and delivery of innovative LC/MS systems for bioprocesses, coordinating across teams to transform concepts into operational solutions that enhance analytical performance and technolo...
4 days ago
$116K - $177K *
Unlock your potential by leading interdisciplinary teams in developing innovative research and product solutions within clinical and life sciences, leveraging your expertise in experimental design and...
Reposted today
$90K - $130K *
Innovate by leading the research in affinity-based technologies and separations. Drive advancements in biomaterials and chromatography systems, bridging bioengineering and analytical science to create...
4 days ago
$120K - $150K *
Take ownership of complex field studies proving AI, data, and cloud solutions for marketers. Design experiments, analyze customer data, and mentor junior staff while influencing enterprise-scale decis...
Reposted today
Senior Scientist - Analytical Development
$90K - $120K *
Drive innovative drug development by leading complex R&D efforts, executing experiments, analyzing critical data, and collaborating effectively across teams to ensure product quality and regulatory co...
Yesterday
Senior Scientist, Science & Technology
$90K - $120K *
Drive your career forward by leading analytical method development in a dynamic environment. Manage projects, mentor teams, and ensure compliance with cGMP standards. Join us to foster innovation and...
3 days ago
$173K - $272K *
Innovate with us to design advanced digital and semantic technologies that transform pharmaceutical development, improve laboratory workflows, and enhance scientific data integration for next-generati...
Yesterday
$131K - $196K *
Deliver innovative oligonucleotide solutions while leading product development and technical projects. Collaborate in a hands-on lab environment, empowering teams through mentorship and driving excell...
1 week ago
Principal Scientist-Analytical Research & Development (ARD)
$140K - $155K *
Engage in the development and implementation of analytical methods for APIs, ensuring compliance with industry standards. Collaborate with project teams while applying advanced techniques and leading...
3 weeks ago
$150K - $175K *
Support and lead complex hardware/software development projects in life sciences. Oversee planning, execution and collaboration to ensure innovative solutions delivery while managing risks, budgets, a...
Yesterday
Senior Scientist I, Product Development
$150K - $165K *
Transform product development by leading QC method innovation, optimizing processes, and ensuring robust assay transfer from R&D to manufacturing. Collaborate across teams to drive success in bringing...
3 weeks ago
Senior Scientist, Product Development
$95K - $120K *
Engineer innovative synthetic routes for new chemical products, manage multiple R&D projects, and collaborate on scale-up activities. Leverage your expertise to drive product development in a fast-pac...
1 week ago
Principal Scientist 1 - Chemical Research & Development
$100K - $130K *
Empower innovative chemical synthesis and development by optimizing existing routes and designing new methodologies. Collaborate with teams to ensure safe, efficient lab operations while leading proje...
3 weeks ago
Supervising Principal Scientist, Process Development
$90K - $210K *
Reimagine the future of cell therapy as an innovative leader driving process development and optimization. Collaborate across teams and external partners to enhance the Cellares platform while mentori...
3 weeks ago
Senior Scientist, Bioanalytical
$80K - $120K *
Develop innovative LC-HRMS methodologies for metabolite analysis. Lead studies on diverse therapeutic modalities, delivering high-quality reports while collaborating with cross-functional teams to dri...
3 days ago
$70K - $95K *
Unlock your potential in a pivotal role enhancing automation in laboratory workflows, collaborating to translate manual assays to automated platforms, and ensuring compliance for cutting-edge drug dev...
Reposted today
Senior Scientist, Bioanalytical Science
$133K - $157K *
Join a dynamic team to advance preclinical discovery in bioanalytical sciences, optimizing methods and managing studies, while fostering a culture of innovation aimed at improving mental health soluti...
2 weeks ago
$173K - $272K *
Lead transformative projects by leveraging digital technologies to enhance lab automation, data integration, and scientific workflows, enabling innovative research in pharmaceutical development across...
Reposted yesterday
$173K - $272K *
Lead the charge in building advanced digital lab environments that integrate AI, robotics, and semantic technologies, transforming pharmaceutical development and enhancing scientific workflows across...
Reposted yesterday
Principal AI Scientist and Lead
$130K - $180K *
Lead the development of innovative AI solutions in preclinical research, managing complex predictive models and agentic systems. Collaborate with stakeholders to ensure secure deployment and complianc...
5 days ago
Principal Scientist - Formulation
$108K - $222K *
Empower our biologics team! Lead the formulation development of complex biologics, driving scientific innovation and collaboration. Shape early-stage strategies and manage multiple projects with a div...
Yesterday
Principal Scientist - Process Development, Upstream
$100K - $130K *
Lead the charge in advancing upstream processing methodologies for mammalian cell culture, facilitating successful tech transfer to cGMP manufacturing while managing multiple projects and driving inno...
2 weeks ago
$120K - $140K *
Unlock potential by leading applied bacteriology programs to enhance global health through innovative research and collaboration. Drive product development and ensure compliance while mentoring future...
3 weeks ago
Principal Scientist I, Molecular Lab Research and Early Development
$111K - $206K *
Unlock potential by spearheading innovative molecular diagnostic assays in oncology. Lead lab-based projects, mentor peers, and translate cutting-edge research into impactful solutions, fostering coll...
Reposted 4 days ago
What is the role of a Principal Scientist?
A Principal Scientist typically leads scientific research, explores innovative ideas, and guides a team of scientists towards achieving the organization's scientific goals.
How much does a Principal Scientist earn on average?
The average salary of a Principal Scientist varies depending on the industry and level of experience. However, on Ladders, you can find Principal Scientists jobs that pay over $100,000.
What qualifications are required for Principal Scientist jobs?
Most Principal Scientist roles require at least a Ph.D. in a relevant scientific field along with several years of research experience. Leadership skills and a proven research track record are typically also essential.
Can I find remote Principal Scientist jobs on Ladders?
Yes, on Ladders, you can find both remote and in-office high-paying Principal Scientist jobs.