Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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$160K - $200K *

Shape the future of product strategy by leading a high-performing team, driving innovation, and ensuring alignment across operations and technology to deliver exceptional customer value and measurable...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Unlock potential by leading complex projects and implementations in cloud-based procurement solutions. Collaborate with cross-functional teams to deliver innovative designs and ensure stakeholder sati...

RemoteRemote

1 month ago

  •   Less than 5 years exp.  •   Enterprise Technology

$74K - $125K *

Optimize the delivery of a cloud-based data platform by managing cross-team coordination, backlog standards, and Agile processes. Collaborate with stakeholders to ensure effective execution of moderni...

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$110K - $115K *

Innovate testing strategies and enhance software quality through automated and manual verification. Collaborate across teams to ensure compliance and optimize processes while leveraging AWS and full-s...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $100K *

Empower People Operations by optimizing processes across the employee lifecycle. Collaborate cross-functionally to enhance efficiency, drive improvements, and maintain high-quality HR services while s...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$243K - $364K *

Lead the charge in designing and deploying large-scale AI systems that foster innovation and modernization. Collaborate with leadership to navigate complex technical challenges, mentor teams, and esta...

Reposted 1 week ago

  •   11 - 15 years exp.  •   Hospitals & Medical Centers

$114K - $171K *

Join our team to provide expert critical care across multiple ICU settings. Collaborate with physicians and healthcare staff to manage critically ill patients, perform essential procedures, and ensure...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$114K - $171K *

Lead the charge in delivering exceptional critical care across multiple campuses, managing complex patient needs and collaborating with multidisciplinary teams to ensure optimal outcomes in intensive...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $155K *

Champion the operational and scientific activities in medical affairs, overseeing Investigator Sponsored Studies and strategic projects. Collaborate with cross-functional teams to enhance data generat...

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Advance your career with a strategic role in Medical Affairs, driving evidence generation and enhancing patient care through cross-functional collaboration and oversight of investigator-sponsored stud...

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Lead and inspire a team of clinicians while managing daily operations to enhance the lives of children with Autism. Drive high-quality care, implement ABA principles, and foster a supportive environme...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Unlock potential by ensuring safe medication dispensing and patient counseling. Collaborate with healthcare providers to enhance therapy outcomes while maintaining compliance with regulations and supp...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Engage with clients to transform complex Enterprise Architecture needs into actionable solutions. Manage implementation workstreams, ensuring effective onboarding and training while fostering strong r...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $150K *

Lead the charge in driving brand awareness and revenue growth for Cryo Nerve Block products. Oversee a team of Territory Managers and Clinical Specialists, utilizing data analysis to strategize and en...

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$170K - $190K *

Champion innovative technical solutions as you lead the architecture and implementation on cutting-edge projects. Collaborate with clients and cross-functional teams to ensure successful delivery and...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$105K - $130K *

Join a team that's redefining billing solutions in the legal sector. Leverage your expertise in law firm financial operations to support sales efforts, conduct client demos, and enhance our innovative...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$78K - $168K *

Join a leading retail health care provider to deliver high-quality, evidence-based patient care. Enjoy autonomy, flexible scheduling, and comprehensive support while engaging in both in-person and vir...

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$142K - $195K *

Pioneer innovative technology strategies that align business vision with IT execution. Collaborate across teams to drive enterprise architecture modernization and deliver impactful solutions while men...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$88K - $134K *

Shape the future of customer success by leading the deployment of IoT solutions for enterprise clients. Your role will bridge sales and strategy, ensuring clients maximize the value of their technolog...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$120K - $145K *

Join a team that's transforming medicine by engaging with KOLs and healthcare professionals. Leverage your clinical expertise to communicate product benefits, support education, and drive strategic in...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$420K - $476K *

Elevate your career by driving Employer Sales growth, shaping go-to-market strategies, and building a high-performing sales organization. This strategic role requires strong leadership and expertise i...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$172K - $210K *

Architect and lead customer-focused application development initiatives, translating business needs into robust software solutions. Leverage modern technologies and AI tools to ensure high-quality, se...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Business Services

$90K - $110K *

Transform patient care by delivering comprehensive assessments and treatments. Collaborate with a dedicated team to enhance patient satisfaction and ensure efficient healthcare delivery in a dynamic e...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$74K - $137K *

Lead the charge in transforming workflows with AI, driving adoption and measurable impact in legal, tax, and trade sectors. Collaborate with clients and teams to design, implement, and evaluate innova...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Media

$210K - $250K *

Drive enterprise-wide physician leadership and clinical oversight for government healthcare programs. Ensure high-quality, compliant healthcare services across federal detention facilities with a focu...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Staffing

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.