Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
California Collaborating Psychiatrist (Clinical & Supervisory Role)
$210K - $250K *
Join a dynamic mental health team as a Collaborating Psychiatrist, providing clinical oversight and direct patient care. Engage in meaningful collaboration with PMHNPs while ensuring compliance and de...
2 weeks ago
$101K - $130K *
Drive financial excellence in the sales organization by managing P&L, optimizing trade spend, and delivering actionable insights to support growth and profitability objectives. Collaborate with leader...
Reposted 3 weeks ago
$87K - $108K *
Empower customer success by providing expert technical support for bioprocessing products. Collaborate with teams to troubleshoot issues, enhance product knowledge, and ensure a positive experience fo...
1 week ago
Senior Product Manager - Reconciliation
$200K - $250K *
Champion the transformation of reconciliation processes, driving financial accuracy and governance through a scalable platform that empowers teams across the organization and supports rapid growth whi...
Reposted 4 weeks ago
Territory Sales Engineer - Connecticut
$85K - $95K *
Drive technical sales growth through customer engagement and training. Oversee value-driven sales processes in the western Connecticut territory, while collaborating internally to exceed customer expe...
Reposted 3 weeks ago
Diagnosis-Related Group (DRG) Auditor III
$73K - $98K *
Join a team that's dedicated to excellence in DRG auditing. Leverage your expertise in MS-DRG and APR-DRG coding to ensure accuracy and compliance while working remotely. Enjoy a collaborative environ...
Today
Sr. Strategic Account Executive, MarketScan
$239K - $358K *
Join a team that's committed to maximizing growth in pharmaceutical accounts through strategic planning and relationship building, focusing on data-driven solutions and real-world evidence to foster l...
Reposted 2 weeks ago
Clinical Research Associate II - FSP
$91K - $137K *
Shape the future of clinical research by managing site operations, ensuring patient safety, and maintaining data integrity. Collaborate with study teams to oversee monitoring activities and drive succ...
2 days ago
Hematology/Oncology Specialist - Tulsa, OK
$170K - $210K *
Develop and execute strategic business plans to enhance patient access and drive sales in the oncology sector, while fostering relationships with key stakeholders and ensuring compliance with industry...
1 week ago
$120K - $135K *
Lead the charge in ensuring the quality and reliability of Enrollment data operations. Collaborate with offshore teams to execute timely processes, troubleshoot issues, and drive continuous improvemen...
Today
Commercial Operations Manager (Remote)
$115K - $140K *
Drive operational excellence in commercial readiness and support cross-functional teams to ensure effective execution of launch strategies and operational priorities in a dynamic biotech environment...
Reposted 3 days ago
Sr Manager Financial Planning and Analysis
$125K - $150K *
Lead the Corporate FP&A function, overseeing forecast consolidation, monthly reporting, and financial analysis. Collaborate with finance and business partners to ensure accuracy and transparency in fi...
2 weeks ago
Vice President, Medicaid Partnerships
$150K *
Elevate Medicaid partnerships by driving strategic sales initiatives, securing contracts, and fostering client relationships. Lead a team to achieve growth targets while navigating market dynamics and...
3 weeks ago
Director, Diagnosis-Related Group Validation (DRGV)
$125K - $150K *
Unlock your potential by leading the development of innovative DRGV services, enhancing billing and coding optimization. Collaborate across teams to create scalable solutions that drive operational ex...
2 weeks ago
$92K - $110K *
Deliver strategic leadership and operational oversight to enhance decision-making processes within the Veterans Health Administration's EHRM, ensuring effective collaboration and communication across...
2 weeks ago
Clinical Informatics Integrator
$110K - $130K *
Lead the charge in managing informatics projects from planning to delivery, ensuring timely decision-making and risk management. Collaborate with cross-functional teams to enhance health information e...
4 weeks ago
Senior Product Builder, Merchant Onboarding
$122K - $180K *
Redefine the Merchant Onboarding experience by designing and prototyping innovative features. Collaborate closely with merchants to automate processes and enhance product velocity, leveraging AI tools...
1 week ago
$68K - $126K *
Transform medical billing operations by leading a team to optimize systems, enhance service delivery, and drive continuous improvement through technology and structured practices, ensuring accountabil...
3 days ago
$90K - $110K *
Manage day-to-day infrastructure and customer support, ensuring optimal server performance, security, and incident response. Collaborate on initiatives to enhance operational security and maintain doc...
3 weeks ago
Principal Consultant - Senior SAP Sales Executive
$150K - $180K *
Transform the SAP sales landscape by leveraging your extensive network and expertise to drive new business acquisition in the manufacturing sector. Own the full sales cycle, from lead generation to cl...
Today
Senior Business Systems Architect
$167K - $183K *
Lead the charge in optimizing G&A technology solutions, enhancing business processes through AI and automation. Collaborate with stakeholders to drive efficiency and compliance, ensuring scalable grow...
3 weeks ago
Associate Director, Innovation Strategy and Execution
$110K - $130K *
Optimize the Innovation portfolio by leading high-impact projects, collaborating with senior leaders, and driving strategic initiatives. Your role will ensure seamless operations and foster growth in...
3 days ago
CMC Program Lead TLX597 & TLX66
$135K - $160K *
Lead the charge in developing and executing CMC strategies for antibody-based radiopharmaceuticals, ensuring alignment with Stage-Gate requirements while managing cross-functional teams and external p...
2 days ago
Chief Financial Officer, The AI Access Initiative
$240K - $270K *
Architect the financial backbone of a rapidly scaling AI-focused organization. Collaborate with leadership to design systems, drive compliance, and enable international expansion while leveraging AI f...
3 weeks ago
$150K - $180K *
Drive the planning and execution of complex therapeutic programs from discovery to clinic. Serve as a senior program management partner, ensuring successful execution and alignment across cross-functi...
6 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.