Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$84K - $87K *
Join us as a Data Operations Engineer, where you'll develop and manage data systems for healthcare claims processing. Collaborate with teams to ensure data accuracy and optimize ETL/ELT pipelines whil...
Reposted 3 weeks ago
$145K - $218K *
Transform your career by driving clinical trial success through strategic site engagement and collaboration with key opinion leaders in Neuroscience and Oncology, enhancing patient enrollment and rete...
Today
$94K - $164K *
Champion innovative business analysis strategies to drive enterprise alignment, enhance decision-making, and deliver measurable outcomes. Collaborate with leadership to shape initiatives that support...
1 week ago
$110K - $125K *
Elevate product strategy and delivery by leading a multidisciplinary team to ensure alignment with stakeholder needs and mission-critical outcomes in a fully remote environment...
1 week ago
$80K - $95K *
Elevate your career as a Senior Accountant, driving day-to-day operations and enhancing internal processes. Collaborate with teams to transition activities, ensuring accuracy and scalability in a fast...
Today
Associate Director, Analytical Development
$185K - $215K *
Take ownership of analytical development initiatives, ensuring compliance, accuracy, and high-quality documentation for multiple projects. Collaborate closely with internal teams and external partners...
Reposted 2 days ago
Warehouse Lead Industrial Engineer - Ryder Last Mile (remote)
$105K - $125K *
Champion continuous improvement initiatives to enhance operations through data analytics and engineering methodologies. Drive performance in safety, quality, and cost, while managing impactful project...
Reposted today
$110K - $130K *
Oversee complex Installation Services projects, ensuring timely delivery and alignment with client needs. Collaborate with cross-functional teams to manage budgets, foster client relationships, and me...
Today
Fraud Audit & Investigations Analyst
$77K - $99K *
Unlock potential by leading investigations into fraud, waste, and abuse in Medicaid. Ensure compliance through quality audits and manage regulatory deliverables, collaborating with stakeholders to uph...
3 weeks ago
Project Manager 2, Patient Monitoring (Northeast and Mid-Atlantic Region)
$85K - $125K *
Collaborate with cross-functional teams to lead large-scale healthcare projects, ensuring timely installation and customer satisfaction. Manage project scope, timelines, and resources while communicat...
Reposted 2 days ago
$79K - $106K *
Join a team that's dedicated to protecting agriculture and natural resources. As an Attorney, you'll provide legal counsel, ensure regulatory compliance, and represent the department in legal proceedi...
2 weeks ago
$110K - $130K *
Accelerate progress at key global brand relationships in personal care. Manage diverse accounts, develop sales strategies, and collaborate cross-functionally to drive growth and enhance customer exper...
1 week ago
$111K - $160K *
Transform category growth by leveraging insights and strategies to enhance customer performance. Collaborate cross-functionally to optimize assortments and drive sales initiatives across diverse retai...
Reposted 3 days ago
1740 - Director, Strategic Sourcing Facilities- Healthcare
$125K - $185K *
Transform the future of healthcare sourcing by leading strategic initiatives, managing a dedicated team, and driving cost-saving projects across Facilities categories to ensure high-quality service de...
2 weeks ago
$176K - $220K *
Lead the charge in driving sustainable revenue growth by managing a high-performing team of Account Executives focused on acquiring new clients in the financial sector, ensuring effective sales execut...
Yesterday
FinOps Engineer, Cloud & Kubernetes Optimization
$98K - $167K *
Lead the charge in optimizing cloud costs by analyzing usage data, automating insights, and collaborating with cross-functional teams to drive efficiency and savings in cloud and containerized workloa...
2 weeks ago
$100K - $140K *
Transform your career by leveraging your RCM expertise to drive sales success. Collaborate with cross-functional teams to enhance customer experiences and optimize billing solutions for small to mediu...
3 weeks ago
Account Executive - Commercial Sector
$100K - $120K *
Join a team that's driving growth in the commercial sector by leveraging data and AI solutions. As an Account Executive, you'll cultivate relationships, manage accounts, and optimize customer success...
Yesterday
$74K - $85K *
Lead the planning and execution of diverse research projects, ensuring alignment with organizational goals. Collaborate with stakeholders to manage timelines, deliverables, and budgets while fostering...
2 weeks ago
Key Account Manager - Houston, TX
$170K - $205K *
Transform the U.S. sales landscape by driving strategic account plans and fostering relationships in the kidney transplant sector, ensuring optimal product utilization and achieving revenue targets th...
3 weeks ago
Medicaid DSH Payment Analysis Specialist
$95K - $105K *
Elevate Medicaid program effectiveness by analyzing DSH payments, ensuring compliance, and collaborating with hospitals and government stakeholders to deliver precise, timely results that enhance heal...
5 days ago
$250K - $325K *
Accelerate your career by leading strategic communications and public policy initiatives that shape the future of AI identity and accountability. Drive visibility, influence industry narratives, and b...
Yesterday
Territory Manager- Orange County/North San Diego
$90K - $100K *
Join a team that's dedicated to transforming behavioral health through strategic business development. You'll connect with healthcare communities, drive patient admissions, and expand market share in...
3 weeks ago
Director/Senior Director Commercial Business Development
$175K - $210K *
Unlock potential by leading strategic business development initiatives that connect biopharmaceutical executives with tailored commercial solutions. Drive growth through relationship-building and inno...
1 week ago
Senior Financial Analyst, FP&A (R&D)
$111K - $167K *
Transform financial operations by driving monthly close processes, managing forecasts, and leveraging AI for process improvements while serving as a key business partner to leadership to enhance strat...
Reposted 3 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.