Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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$170K - $210K *

Unlock potential by fostering relationships within the oncology community, executing strategic business plans, and ensuring patient access to therapies while collaborating across functions to drive sa...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Join a team that's driving analytical excellence in biologics development. Lead method development and validation while ensuring compliance with cGMP standards. Collaborate across functions to support...

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Manage key capital markets activities, overseeing debt operations, cash flow forecasting, and financial risk management. Collaborate with stakeholders to prepare executive materials and support pensio...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Partner with us to design and implement cloud-native data solutions, ensuring secure and reliable data exchange across platforms. Collaborate with teams to enhance data accessibility and support advan...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Champion privacy solutions by engaging with clients, delivering tailored demos, and driving sales success. Leverage your expertise to influence product development and navigate the intersection of AI...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $165K *

Pioneer operational excellence in Design leadership, managing workflows, prioritizing projects, and developing talent. Collaborate cross-functionally to enhance Design integration in AI-driven product...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Build lasting relationships and drive customer success by leveraging insights and data to enhance client engagement and retention. Collaborate cross-functionally to inform product improvements and sup...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$96K - $133K *

Join a team that's dedicated to delivering high-quality projects on time and within budget. As a key player, you'll coordinate efforts across departments, ensuring effective communication and resource...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Contribute to the success of multiple clinical research sites by leading operations, ensuring compliance with regulations, and fostering team development to enhance patient care and operational excell...

United StatesRemote

Reposted 1 month ago

  •   5 - 7 years exp.  •   Healthcare

$89K - $121K *

Shape the future of customer engagement by optimizing Genesys Cloud access management. Collaborate with cross-functional teams to enhance security, streamline user provisioning, and ensure compliance...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Shape the future of IT capacity management by ensuring resources meet business demand in a regulated environment. Collaborate with teams to optimize performance, manage risks, and align strategies for...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$164K - $245K *

Transform vendor legal operations by leading negotiations and enhancing processes. Collaborate with cross-functional teams to streamline agreements and empower stakeholders, ensuring efficiency and sc...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $138K *

Manage regional meetings and events, ensuring seamless execution and compliance. Oversee budgets, vendor relationships, and logistics while collaborating with cross-functional teams to meet organizati...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$140K - $193K *

Champion innovation by leading technical capability programs that enhance product quality, streamline processes, and drive consumer satisfaction. Collaborate with cross-functional teams to ensure succ...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Food & Beverages

$80K - $95K *

Partner with us to enhance clinical IT solutions as an Epic Analyst II, providing critical support, training, and implementation for Epic EHR systems. Collaborate with teams to optimize workflows and...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Join a dynamic team to evaluate strategic investments and growth opportunities in healthcare. Leverage market insights and financial modeling to shape multi-year business strategies, collaborating acr...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Lead compliance efforts in marketing by ensuring all materials meet legal standards. Collaborate with cross-functional teams to apply guidelines effectively while maintaining a keen attention to detai...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $120K *

Join a dynamic team as you oversee IT operations, user lifecycle management, and security for a growing organization. This hands-on role allows you to set standards and processes while serving as the...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$128K - $135K *

Drive impactful insights by transforming data into strategic decisions that enhance retail partnerships. Collaborate with key stakeholders to deliver analytics that support growth and optimize perform...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$104K - $143K *

Join a dynamic team to lead Quality Assurance efforts in Long-Term Services and Supports. Oversee compliance, collaborate with external partners, and drive operational excellence while ensuring adhere...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $140K *

Unlock potential by driving growth and adoption of innovative surgical glaucoma technology. Collaborate with surgeons and staff to deliver exceptional support and education, while building sustainable...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Healthcare

$102K - $190K *

Pioneer the future of endpoint security by leading a dynamic engineering team, ensuring operational excellence, and driving innovative capabilities to protect enterprise assets while aligning with bus...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Drive your career with a pivotal role in shaping product strategy and delivery, enhancing member experiences in healthcare. Collaborate across teams to define problems, prioritize outcomes, and levera...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $150K *

Join a team that's dedicated to transforming the mental health landscape, providing comprehensive telehealth care for individuals with eating disorders while collaborating closely with a multidiscipli...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $163K *

Champion the analytical validation of NGS assays, driving real-world evidence studies and collaborating with cross-functional teams to enhance oncology applications and support regulatory submissions...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.