Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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$100K - $115K *

Grow your career with a dynamic team driving innovative strategies and customer engagement. Leverage your sales expertise to enhance product visibility and exceed business goals in a supportive, colla...

RemoteRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$100K *

Elevate sales strategies by owning the full sales cycle, building C-Suite relationships, and delivering impactful solutions to healthcare organizations across the Western US...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$221K - $335K *

Elevate clinical research by leading innovative studies, ensuring data integrity and patient safety. Collaborate cross-functionally to drive strategic initiatives and enhance clinical development whil...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$73K - $110K *

Champion compliance excellence by managing HR programs, ensuring alignment with laws, and enhancing processes. Collaborate across teams to minimize risk and support organizational growth while navigat...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$160K - $190K *

Join a team that's dedicated to providing expert anesthesia care. As a CRNA, you will collaborate with surgeons, utilizing your skills to enhance patient outcomes in a supportive environment that valu...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$137K - $205K *

Transform customer relationships by leading a team to enhance account management, drive product adoption, and ensure client success in the healthcare sector, fostering growth and retention across dive...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Join a team that's dedicated to managing diverse publications projects from start to finish. Collaborate with multidisciplinary teams, ensure client satisfaction, and maintain project budgets while dr...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$70K - $100K *

Join a team that's dedicated to optimizing Epic Resolute Professional Billing. Support daily operations, troubleshoot issues, and enhance workflows while collaborating with analysts and users to ensur...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$129K - $168K *

Optimize internal monitoring processes by leading clinical evaluations and audits across operational functions. Drive compliance, enhance decision-making, and foster team development to ensure alignme...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$70K - $105K *

Manage and oversee multiple medical communications projects, ensuring timely delivery and operational excellence while collaborating with cross-functional teams and clients to drive impactful healthca...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$58K - $125K *

Accelerate progress at the intersection of finance and strategy, driving cost accounting excellence and profitability analysis. Collaborate with cross-functional teams to enhance financial reporting a...

RemoteRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$220K - $260K *

Drive credit and fraud strategy for a lending business. Lead a high-performing team, manage risk and profitability, and partner with executives and stakeholders to achieve strategic objectives and dev...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Finance & Insurance

$80K - $95K *

Drive customer support excellence by managing a frontline team to ensure timely resolutions, operational efficiency, and a culture of continuous improvement, paving the way for stellar service in heal...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Champion the design and configuration of Ellucian Colleague Financial Aid systems, ensuring alignment with client strategies while providing expert technical support and training to enhance operationa...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$150K - $180K *

Contribute to the design and execution of clinical studies, ensuring data integrity and quality. Collaborate cross-functionally to drive study activities and support regulatory efforts, while enhancin...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$174K - $234K *

Shape the future of Hematology analytics by leading strategic insights and performance initiatives. Collaborate with cross-functional teams to enhance field execution and drive commercial success thro...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$73K - $130K *

Drive the acquisition and usability of clinical data to enhance healthcare outcomes. Collaborate with diverse teams to analyze data gaps, implement integrations, and optimize processes, ensuring timel...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$103K - $176K *

Transform downstream marketing for cutting-edge medical devices. Drive product launches, develop compelling content, analyze market trends, and ensure regulatory compliance across global regions while...

RemoteRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Champion the success of a dynamic lab team by overseeing daily operations, ensuring compliance, and driving performance. Collaborate across departments to enhance processes and maintain high-quality s...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$144K - $288K *

Lead the charge in transforming customer identity platforms, driving modernization and operational excellence while overseeing a multi-team engineering organization to enhance security and customer en...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $130K *

Develop and implement business rules for credit strategy, collaborating with Risk, Compliance, and Tech teams. Ensure accurate decision logic, maintain documentation, and support testing for optimized...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Finance & Insurance

$75K - $90K *

Champion patient care by utilizing telehealth technologies to deliver high-quality nursing services. Collaborate with interdisciplinary teams to improve outcomes and ensure compliance with healthcare...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$130K - $150K *

Advance your career by leading product strategy for supply chain orchestration. Drive technical decisions, collaborate with cross-functional teams, and leverage AI to enhance workflows, ensuring measu...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$175K - $225K *

Lead the charge in shaping product strategy and execution, driving innovation and collaboration across teams to deliver impactful solutions in a fast-paced B2B SaaS environment. Own the product roadma...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $166K *

Optimize site contract management by reviewing, drafting, and negotiating various legal agreements. Collaborate with clinical teams to ensure timely deliverables and serve as a subject matter expert i...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.