Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Payment Integrity Program Manager
$73K - $120K *
Drive the success of inpatient Payment Integrity programs by overseeing audits, ensuring compliance, and enhancing quality across teams and vendors. Collaborate with stakeholders to optimize processes...
3 weeks ago
Senior Director, Counsel - Litigation, Legal Policy and Strategy (USA Remote role)
$199K - $321K *
Explore a dynamic role shaping litigation and policy strategy in the pharmaceutical sector. Collaborate with senior leaders and external stakeholders to navigate complex legal landscapes, ensuring pat...
Yesterday
Sr. Engineer, AI Cyber Security
$140K - $187K *
Innovate the future of AI security by designing and implementing robust defenses against adversarial threats, ensuring the integrity of AI systems while fostering innovation and collaboration across c...
3 weeks ago
Senior Clinical Research Associate - Oncology
$105K - $140K *
Lead the charge in monitoring clinical study sites, ensuring data integrity and patient safety while collaborating with diverse teams to enhance study delivery and compliance with regulatory standards...
Reposted 1 week ago
Registered Nurse (RN) - $5k Bonus
$66K - $99K *
Unlock potential by providing compassionate care to individuals facing substance use and mental health challenges. Join a dedicated team committed to making a difference in the community through excep...
1 week ago
Staff Product Manager, BioPharma Platforms
$146K - $224K *
Elevate clinical development by leading the strategy for biopharma platforms. Drive product lifecycles, collaborate with cross-functional teams, and ensure compliance while transforming workflows into...
2 weeks ago
Director, Product Quality Lead
$172K - $232K *
Lead the charge in advancing global quality initiatives, ensuring product excellence, and fostering expertise in quality risk management while collaborating across teams to enhance compliance and oper...
Reposted 3 weeks ago
Senior Accountant, AP - Dealer Receivables
$80K - $95K *
Manage dealer receivables by ensuring accurate accounting, reporting, and financial controls. Collaborate cross-functionally to enhance processes, drive automation, and maintain compliance while suppo...
3 weeks ago
Associate Director, Analytics Governance & Operations
$152K - $283K *
Accelerate analytics governance and operations by leading initiatives that enhance decision-making processes, streamline reporting, and modernize workflows across teams, ensuring effective collaborati...
2 days ago
$110K - $130K *
Join a team that's shaping the future of financial management in R&D. Drive project budgets, forecasts, and insights while collaborating with cross-functional teams to ensure financial efficiency and...
1 week ago
$94K - $107K *
Support and enhance data governance operations by collaborating with teams to implement standards, manage data cataloging, and drive tool adoption, ensuring compliance and effective governance workflo...
3 weeks ago
Senior Manager (Solutions Delivery)
$106K - $213K *
Transform the future of healthcare analytics by leading client engagements and delivering high-quality solutions. Collaborate across teams to ensure timely execution and drive operational excellence f...
Reposted 1 week ago
Northern VA Inova Float Pool - CRNA
$291K *
Engage with a dynamic team as a CRNA in a floating role, providing regional anesthesia across multiple facilities. Enjoy autonomy, diverse cases, and a supportive environment with competitive compensa...
1 week ago
Senior Manager, Vaccine Demand & Implementation
$106K - $122K *
Advance global immunization efforts by managing strategic partnerships and implementing evidence-based solutions to enhance vaccine demand and delivery in low and middle-income countries, focusing on...
Reposted today
$75K - $90K *
Transform financial insights into strategic initiatives, supporting planning and analysis as the organization scales. Collaborate across teams to enhance budget management, reporting, and performance...
Reposted 3 days ago
$156K - $247K *
Lead the charge in patient engagement strategy, optimizing support programs and enhancing the patient journey from consideration to conversion. Collaborate across teams to amplify patient voices and d...
2 weeks ago
Hemostasis Sales Specialist - East Texas Region
$99K - $136K *
Join a dynamic team as a strategic growth architect, driving revenue and market share expansion in the Hemostasis portfolio. Leverage your expertise in complex healthcare sales to influence decision-m...
2 weeks ago
Senior Therapeutic Area Specialist, Oncology- Omaha, NE
$144K - $175K *
Lead the charge in driving demand for BMS medicines by engaging healthcare providers with impactful scientific dialogue, ensuring a superior customer experience while achieving sales targets in a dyna...
Yesterday
Medical Monitor (US Board-Certified Gastroenterologist)
$210K - $250K *
Innovate with us to enhance patient safety in global clinical studies. As a key medical expert, you'll provide critical input, oversee trial safety, and collaborate with teams to ensure compliance and...
2 weeks ago
Senior Director, Head of Research & Early Development
$228K - $342K *
Empower your career by leading strategic project management initiatives across early drug development. Drive process optimization, cultivate high-performing teams, and collaborate with executives to a...
Yesterday
Quality Data & Finished Goods Specification Manager
$90K - $110K *
Optimize the quality assurance process by leading data analytics and specification development. Drive actionable insights from complaints and non-conformance data while ensuring compliance across manu...
Reposted 3 days ago
$80K - $110K *
Transform financial operations by providing analytical support, enhancing reporting processes, and collaborating with cross-functional teams to drive profitability and efficiency in budgeting and fore...
2 days ago
Head of Business Development - Biologics
$160K - $200K *
Accelerate growth in Biologics by leading global business development efforts, driving new market creation, and forging strategic partnerships. Collaborate across teams to implement data-driven strate...
1 week ago
$160K - $190K *
Transform ambiguity into action by driving strategic initiatives across functions. Collaborate with executives to architect programs that enhance operational efficiency and deliver measurable business...
3 weeks ago
$66K - $102K *
Elevate your career by joining our consulting team to design and implement SAP PP/QM solutions, driving value for clients through innovative strategies and expert knowledge transfer in a dynamic, glob...
4 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.