Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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$190K - $210K *

Collaborate with cross-functional teams to drive clinical biomarker strategy and execution, translating discovery insights into actionable approaches that enhance patient outcomes in early neuroscienc...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$54K - $159K *

Champion contract negotiations by driving initiatives, cultivating relationships, and ensuring compliance with performance goals. Leverage expertise to support cost-saving strategies and enhance cross...

RemoteRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Lead the delivery of comprehensive medical care by assessing, diagnosing, and treating patients. Collaborate with healthcare teams to enhance patient education and ensure quality care while adhering t...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$204K - $340K *

Lead the charge in generating impactful real-world evidence to support oncology products, ensuring alignment with market needs and regulatory requirements while collaborating across teams to drive evi...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Elevate your career by supporting clinical studies through scientific expertise, operational delivery, and compliance. Collaborate with cross-functional teams and stakeholders to ensure successful tri...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Engineer innovative fraud detection models and features to identify high-risk activities while ensuring a seamless experience for legitimate customers. Collaborate with teams to translate insights int...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$106K - $132K *

Drive local market execution and performance by collaborating with teams, leveraging data for growth, and managing distributor relationships to ensure alignment with strategic goals and operational ex...

RemoteRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Food & Beverages

$90K - $100K *

Join a team that's redefining accounting excellence by managing month-end closes, revenue recognition, and international audits. Leverage your CPA expertise to enhance financial integrity and drive pr...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$159K - $273K *

Shape the future of home listings by driving supply growth and enhancing buyer experiences. Lead AI-driven initiatives to optimize inventory presentation and engagement, ensuring Redfin remains the go...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $110K *

Analyze diverse research projects to provide actionable insights for leadership. Collaborate with a dynamic team, utilizing AI tools and your curiosity to tackle complex questions and deliver clear, c...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$215K - $408K *

Drive medical leadership in quality improvement and utilization management, ensuring effective care delivery and cost containment. Collaborate with clinical teams to enhance patient outcomes and suppo...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$164K - $205K *

Lead the design and analysis of clinical validation studies, ensuring regulatory compliance and driving innovative research in molecular diagnostics. Collaborate with cross-functional teams to enhance...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$143K - $193K *

Accelerate progress at the forefront of data-driven transformation in life sciences. Collaborate with leadership to shape and execute enterprise data architecture initiatives, ensuring scalable, trust...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Transform clinical operations by leading a dynamic team, ensuring high-quality trial management, and driving innovation through technology and AI solutions. Your strategic oversight will enhance perfo...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$126K - $173K *

Drive impactful measurement strategies by leading cross-functional teams to define and deliver comprehensive reporting solutions that enhance decision-making and optimize business outcomes across the...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$192K - $303K *

Empower innovation as you lead the strategy and development of core platform primitives, driving the future of agentic systems and ensuring product teams can rapidly create and deploy advanced agents...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $185K *

Develop innovative healthcare products by collaborating with cross-functional teams. Leverage your technical expertise to enhance platform capabilities and deliver impactful solutions that improve pat...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$128K - $145K *

Support the full life cycle of vendor contracts, from negotiation to execution. Collaborate with stakeholders to manage legal risks and ensure compliance in a fast-paced environment, focusing on healt...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Drive success by educating healthcare providers on ZYNLONTA® in the Michigan/Ohio territory. Leverage insights to foster relationships, achieve sales goals, and enhance patient experiences through eff...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$158K - $185K *

Unlock your potential by leading the design and delivery of a transformative Medicaid data platform. Collaborate with stakeholders and guide teams to modernize healthcare systems through innovative cl...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$200K - $290K *

Contribute to the advancement of cancer therapies by managing analytical development and quality control operations, ensuring compliance with regulatory standards, and collaborating across teams to en...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$88K - $105K *

Analyze and optimize whey and ingredient processes to enhance efficiency, quality, and yield. Lead projects, ensure compliance with safety standards, and provide technical support to improve operation...

2 weeks ago

  •   5 - 7 years exp.  •   Food & Beverages

$95K - $115K *

Transform clinical quality by supporting training initiatives, monitoring clinician performance, and ensuring compliance with quality standards for successful operational processes and clinician suppo...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Strategize and lead complex technical analysis to bridge business needs with IT solutions, ensuring compliance and efficiency across enterprise operations while mentoring teams and driving continuous...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$175K - $400K *

Join a team that's shaping the future of digital supply chain management. You'll architect and optimize ERP, PLM, and inventory systems, ensuring data integrity and operational scalability across glob...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.