Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$120K - $165K *

Elevate your career as a Scientific Product Owner, driving innovation in clinical genomics software. Collaborate with cross-functional teams to translate scientific needs into actionable requirements...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$63K - $101K *

Optimize compliance in Interventional Radiology charge capture by conducting audits, educating teams, and enhancing coding practices. Collaborate with clinical departments to identify and rectify codi...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$236K - $354K *

Elevate clinical operations by leading global study management, driving strategic vision, and ensuring high-quality trial execution. Collaborate across teams to optimize resources and foster a culture...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $125K *

Join our dynamic team to develop innovative sourcing strategies, lead supplier negotiations, and drive value creation within the Americas, contributing significantly to our growth and sustainability g...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$120K - $150K *

Champion integrated project management for complex pharmaceutical advertising, leading cross-functional teams to ensure timely delivery within scope and budget while mentoring junior staff and enhanci...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Join a team that's dedicated to enhancing client relationships and driving success. Oversee client performance, mentor staff, and ensure compliance while collaborating with various departments to deli...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $130K *

Partner with us to drive product innovation and marketing strategies across dietary supplements and topical hair care. Collaborate with cross-functional teams to launch new products, ensuring alignmen...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$168K - $231K *

Drive transformation by partnering with cross-functional teams to design and implement effective product operations, ensuring alignment with strategic goals and enhancing organizational effectiveness...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$145K - $155K *

Join a team that's dedicated to providing virtual behavioral health services to military personnel. Utilize your expertise in clinical psychology to deliver evidence-based treatments and support patie...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$143K - $193K *

Transform clinical operations by leading regional study delivery, ensuring quality and compliance while managing timelines and budgets. Collaborate with cross-functional teams to drive study success a...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$117K - $160K *

Champion profitable growth by managing E&S commercial property and casualty underwriting. Leverage strong technical skills and relationships to assess risks, deliver competitive quotes, and optimize p...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$83K - $129K *

Lead the charge in advanced compliance activities, ensuring administrative solutions align with laws and regulations. Utilize AI tools to enhance efficiency, guide teams, and deliver scalable complian...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Join a team that's dedicated to ensuring financial integrity and compliance. In this hands-on role, you'll manage revenue recognition and accounting processes, collaborating across departments to supp...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $230K *

Transform the oncology landscape by driving product success and building strong relationships with healthcare professionals. Leverage your expertise to enhance patient access and deliver innovative so...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$75K - $104K *

Empower a high-performing sales team by leading, coaching, and optimizing processes to exceed targets. Drive operational excellence and foster a collaborative culture while ensuring seamless customer...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Join us to provide expert application support for cutting-edge separation technologies. Engage with customers throughout their journey, ensuring successful implementation and adoption while collaborat...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Accelerate progress at clinical sites by enhancing patient recruitment strategies and supporting Oncology studies. Collaborate with teams to optimize enrollment processes and ensure effective communic...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Lead cross-functional teams to develop and execute a strategic product roadmap, integrating market insights and performance metrics to drive customer-centric solutions in the diagnostics and genomics...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Empower your career by serving as a legal partner in procurement and supply chain, providing expert guidance and support in contract negotiation, vendor relations, and operational risk management acro...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Food & Beverages

$120K - $140K *

Partner with us to drive growth in industrial accounts, leveraging your sales expertise to expand relationships and deliver innovative water treatment solutions that meet the needs of our customers an...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Grow your career in pharmaceutical sales by building relationships in dermatology. This role involves extensive travel to engage with healthcare professionals, promote products, and achieve sales goal...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$113K - $142K *

Elevate your career by joining our dynamic team to design, develop, and optimize bioinformatics software tools and systems, ensuring robust functionality and compliance in a fast-paced, innovative env...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$95K - $117K *

Champion integrated health initiatives across multiple countries, providing strategic oversight and leadership for malaria, maternal health, and infectious disease programs. Ensure quality interventio...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$161K - $268K *

Unlock opportunities by managing oncology partnerships across Washington and Alaska. Drive business plans, enhance patient access, and collaborate with cross-functional teams to achieve impactful resu...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$172K - $232K *

Lead the GCP Inspection Management team to ensure inspection readiness and compliance. Oversee strategy development, cross-functional collaboration, and risk mitigation for successful regulatory inspe...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.