Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Oncology Sales Representative - Minneapolis, MN
$142K - $224K *
Join a dynamic team as you engage with oncology stakeholders, educate on products, and drive sales growth in a diverse territory. Collaborate with colleagues to enhance customer experiences and achiev...
1 week ago
$80K - $95K *
Deliver comprehensive psychological assessments and evidence-based interventions, guiding treatment plans for complex cases. Collaborate with interdisciplinary teams and supervise trainees while enhan...
Yesterday
Director of Strategic Partnerships
$100K - $150K *
Transform the future of business development by building strategic partnerships across key professional services. Drive growth through relationship-building and co-closing deals, while shaping a natio...
3 weeks ago
Director, Client Media Solutions
$100K - $140K *
Drive innovative media strategies for healthcare clients, leveraging audience insights and performance data. Collaborate with cross-functional teams to enhance planning processes and deliver impactful...
1 week ago
$105K - $150K *
Transform healthcare insights by leading client engagements with real-world data. Drive business development and project delivery while building long-term client relationships in a dynamic, hybrid wor...
Reposted 1 week ago
Senior Epic Analyst-Healthy Planet - Care Coordination
$83K - $222K *
Innovate your career with a Senior Epic Analyst role focused on designing and optimizing Epic solutions for population health and care coordination, while mentoring junior analysts and collaborating w...
Reposted 3 weeks ago
$120K - $145K *
Unlock product potential by leading the development of innovative food safety solutions. Collaborate with cross-functional teams to address complex industry challenges and drive scalable product strat...
3 days ago
$90K - $110K *
Analyze healthcare data to enhance clinical insights and improve medication use. Collaborate with cross-functional teams to develop analytics tools and real-world evidence studies, driving better heal...
1 week ago
$125K - $150K *
Manage diverse legal matters in a dynamic industrial environment, providing strategic support across commercial contracts, regulatory compliance, and corporate governance while collaborating closely w...
2 weeks ago
Senior Scientific Director, Neurodegenerative Diseases
$265K - $300K *
Shape the future of neurodegenerative disease diagnostics by leading scientific strategy, driving research programs, and building expert networks to establish industry leadership in innovative solutio...
1 month ago
$120K - $145K *
Unlock potential by leading pre-sales technical strategies that align solutions with client needs, driving revenue growth and retention through collaboration with sales teams and delivering tailored p...
Yesterday
Hemostasis Sales Specialist - Northern California Region
$99K - $136K *
Elevate your career by driving strategic growth in Hemostasis solutions. As a key player, you'll lead complex sales cycles, cultivate executive relationships, and deliver measurable value across healt...
2 weeks ago
$165K - $205K *
Drive the future of food access and benefits by leading product strategy and execution. Own the roadmap for innovative services that enhance member experiences and streamline operations across diverse...
3 weeks ago
Medical Review Nurse II - SNF/MDS Auditor
$90K - $105K *
Tackle medical claims audits in a dynamic remote environment, collaborating with a skilled team to ensure compliance and accuracy in Skilled Nursing Facility reviews while enhancing audit processes an...
3 days ago
$93K - $104K *
Empower patient care by providing essential nursing services across diverse settings. Collaborate with healthcare teams to ensure optimal patient outcomes while enjoying flexible scheduling and compet...
Yesterday
$93K - $104K *
Join our team to provide exceptional nursing care across various settings. Enjoy flexible scheduling and competitive pay while making a difference in patients' lives through assessments, medication ad...
Yesterday
$93K - $104K *
Take ownership of patient care by delivering high-quality nursing services across various settings. Collaborate with healthcare teams to assess, document, and implement care plans while ensuring a saf...
Yesterday
$93K - $104K *
Transform patient care by providing essential nursing services across diverse settings. Enjoy flexible scheduling and competitive pay while making a meaningful impact in the lives of patients in vario...
Yesterday
System Manager of Enterprise Resilience
$110K - $130K *
Lead the charge in enhancing enterprise-wide Business Continuity programs, ensuring critical healthcare services remain uninterrupted. Collaborate across teams to strengthen resilience and deliver mea...
1 week ago
$80K - $95K *
Drive supply chain excellence by leading program activities, ensuring performance, and collaborating across teams to meet organizational objectives. Leverage your project management skills to influenc...
3 weeks ago
Solutions Architect (Contract)
$156K - $187K *
Transform the data landscape by designing and implementing robust integration solutions. Collaborate with cross-functional teams to enhance analytics infrastructure, ensuring seamless data flow and go...
3 weeks ago
Senior Manager, Commercial Advanced Analytics
$148K - $222K *
Pioneer advanced analytics strategies to optimize omnichannel investments, translating global performance data into actionable insights. Collaborate with cross-functional teams to drive measurable com...
3 weeks ago
Care Manager, Telephonic Nurse
$71K - $97K *
Transform patient care by guiding transitions and ensuring optimal service continuity. Leverage your nursing expertise to navigate healthcare options and advocate for patients in need of post-acute se...
Yesterday
Sr. / Principal Medical Writer (Regulatory focus) - Sponsor-dedicated; NA/CAN/UK
$110K - $130K *
Advance your career by leading medical writing projects in a regulatory environment. Collaborate with cross-functional teams to produce high-quality documents, ensuring compliance with industry standa...
6 days ago
Sr. / Principal Medical Writer (Regulatory focus) - Sponsor-dedicated; NA/CAN/UK
$80K - $175K *
Champion the creation of high-quality regulatory documents, managing writing tasks and leading reviews. Collaborate across teams to ensure clarity and compliance, mentoring junior writers while delive...
Reposted 2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.