Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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$130K - $150K *

Accelerate growth by managing sales strategies across CA and parts of the Midwest. Lead market development efforts, achieve sales goals, and collaborate with cross-functional teams to enhance customer...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$120K - $145K *

Transform complex data systems by designing and implementing scalable solutions that enhance analytics and drive business intelligence in a collaborative, Agile environment focused on healthcare compl...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Healthcare

$180K - $220K *

Join a team that's dedicated to transforming patient care through a Whole Health System, managing inpatient medical cases, and collaborating with healthcare professionals to enhance the well-being of...

2 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Drive growth by leading a team of provider relations representatives, managing key provider relationships, and implementing strategies to enhance service offerings and revenue within the compounding p...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$210K - $230K *

Accelerate progress at the forefront of clinical supply chain management, leading strategic initiatives to ensure seamless delivery of investigational products for global trials while collaborating ac...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$177K - $338K *

Champion DMPK project leadership by ensuring high-quality data delivery and supporting drug candidate progression through innovative modeling and cross-functional collaboration in a dynamic biotech en...

RemoteRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $90K *

Shape the future of Cell and Gene Therapy by providing expert application support, driving customer integration, and enhancing product utilization through collaboration and technical guidance across t...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$272K - $340K *

Lead the charge in shaping a global supply chain strategy that ensures seamless delivery of clinical and commercial products. Build a high-performing team and foster partnerships to meet regulatory st...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$72K - $108K *

Unlock potential by developing strategic business plans and conducting impactful sales presentations. Achieve sales goals while fostering relationships and ensuring compliance with ethical practices i...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$204K - $276K *

Lead the charge in global observational research, driving clinical operational strategy and execution. Collaborate with cross-functional teams to ensure quality and efficiency in evidence generation t...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Join a team that's redefining scientific data management in drug discovery. Lead the scientific data team, bridging scientists and engineers to ensure data integrity, quality, and innovative solutions...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$149K - $187K *

Drive regional sales success by leading a team of Territory Sales Managers, fostering a culture of accountability and collaboration, and executing strategic initiatives to achieve performance targets...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$144K - $173K *

Shape the future of pharmaceutical media by leading client strategy and integrated media delivery. Drive audience engagement, manage high-impact relationships, and leverage data insights to achieve me...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$80K - $95K *

Transform healthcare initiatives by leading projects from inception to completion. Coordinate teams, manage timelines, and ensure clear communication to drive organizational priorities and deliver mea...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$126K - $210K *

Lead strategic initiatives to enhance referral growth and provider engagement across chronic therapy markets. Drive collaboration among cross-functional teams to optimize patient progression and deliv...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$90K - $105K *

Collaborate with clients and teams to manage projects, expectations, and delivery, ensuring high standards and strategic growth in a fast-paced medical affairs environment. Leverage experience to iden...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$96K - $118K *

Join a dynamic team to develop and manage supply chain contracting strategies that optimize costs and enhance value for member pharmacies. This role involves supplier negotiations, category performanc...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$66K - $189K *

Innovate analytical strategies to enhance toxicology assessments, ensuring compliance and data integrity. Collaborate across teams to drive project success and influence decision-making through advanc...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$222K - $356K *

Unlock your potential as a Senior Safety Physician, leading safety oversight for late-stage CNS clinical development. Collaborate with cross-functional teams to drive risk management and regulatory su...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$46K - $122K *

Join a team that's redefining healthcare contracts by leveraging financial expertise and strategic negotiation skills to enhance client relationships and drive business success in a dynamic environmen...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$46K - $122K *

Unlock potential by joining a strategic team that formulates pricing strategies and analyzes complex data modeling for financial profitability in a dynamic healthcare environment. Drive impactful clie...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$72K - $108K *

Accelerate progress at driving sales growth through strategic territory management, effective customer engagement, and adherence to ethical practices while achieving quarterly goals and fostering stro...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$260K - $270K *

Unlock your potential as a Psychiatrist, providing advanced outpatient care via virtual platforms. Collaborate with multidisciplinary teams to deliver comprehensive treatment for diverse psychiatric c...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$127K - $159K *

Transform corporate communications by crafting compelling content that enhances reputation, engages employees, and supports strategic initiatives. Collaborate across teams to manage projects and ampli...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Lead the charge in managing supply chain and logistics operations, ensuring accurate inventory control and timely shipments. Collaborate with internal and external partners to optimize processes and s...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.