Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Statistical Programmer/Analyst Consultant (Need solid oncology background) Remote in US
$110K - $130K *
Champion statistical programming excellence in oncology clinical trials. Lead programming activities, collaborate with cross-functional teams, and ensure high-quality deliverables from study start-up...
2 weeks ago
Associate Director, Talent Analytics & Assessment Science
$132K - $193K *
Unlock potential by leading the enterprise employee listening strategy, enhancing assessment science, and applying analytics to drive data-informed talent decisions. Collaborate with cross-functional...
2 weeks ago
Director, Neurology - Thought Leader Liaison (SOUTH)
$245K - $265K *
Drive strategic partnerships with Medical Experts in neurology, enhancing patient care through insights and collaboration. This field-based role requires strong relationship-building and cross-functio...
2 weeks ago
Senior Oncology Account Manager, Fort Myers
$150K - $230K *
Unlock potential by driving oncology product success through strategic relationships and innovative solutions. Lead efforts to enhance patient access and exceed performance goals while navigating a co...
1 week ago
Associate Director, CMC Operations
$155K - $190K *
Manage the planning and execution of CMC operations across multiple development programs, ensuring alignment with regulatory milestones and efficient collaboration with cross-functional teams and CDMO...
1 week ago
Sr Manager, Global Regulatory Affairs (AI/ML)
$150K - $180K *
Unlock potential by guiding global regulatory strategies for innovative AI/ML healthcare solutions. Collaborate cross-functionally to navigate complex regulations while balancing innovation and patien...
Reposted 4 weeks ago
Endpoint Engineer I (JAMF & Mac Experience required)
$80K - $100K *
Take ownership of complex desktop and mobile device support, ensuring high customer satisfaction. Administer enterprise management platforms and collaborate with teams to deliver effective technology...
1 week ago
Endpoint Engineer I (JAMF & Mac Experience required)
$80K - $100K *
Transform endpoint management by leading complex support initiatives, ensuring seamless service delivery across diverse environments. Collaborate with teams to enhance user experience and optimize tec...
1 week ago
Licensed Practical Nurse (LPN)
$83K - $87K *
Join a dynamic team providing essential nursing care across various settings. Enjoy flexible scheduling and competitive pay while making a difference in patients' lives. Your expertise will support lo...
Yesterday
Licensed Practical Nurse (LPN)
$83K - $87K *
Join a team that's dedicated to providing exceptional care in various settings. Enjoy flexible scheduling and competitive pay while making a difference in patients' lives as a Licensed Practical Nurse...
Yesterday
Licensed Practical Nurse (LPN)
$83K - $87K *
Deliver exceptional patient care by providing skilled nursing services in various settings. Collaborate with healthcare teams to enhance patient outcomes while enjoying flexible scheduling and competi...
Yesterday
Licensed Practical Nurse (LPN)
$83K - $87K *
Unlock your potential as a Licensed Practical Nurse, providing essential care in diverse settings. Enjoy flexible scheduling and competitive pay while making a meaningful impact on patients' lives acr...
Yesterday
Program Executive, Drug Development and Commercial
$285K - $325K *
Drive transformational patient impact by leading cross-functional teams and executing strategic drug development programs in an agile environment. Foster collaboration and accountability to deliver in...
Reposted 2 weeks ago
$119K - $179K *
Lead the charge in architecting FHIR-compliant data models to enhance clinical data integration and usability, supporting patient care and research initiatives across the organization...
3 weeks ago
Executive Director, Statistical Programming
$298K - $340K *
Join a dynamic team to lead strategic statistical programming initiatives, ensuring top-quality deliverables and compliance across diverse clinical trials. Collaborate with cross-functional partners t...
Reposted 3 weeks ago
$160K - $200K *
Transform client relationships by driving business growth, securing profitable projects, and leveraging market access expertise. Lead teams to exceed expectations while identifying industry trends and...
Yesterday
Regional Business Manager - East Region
$110K - $130K *
Lead the charge in driving regional sales growth by developing strategic plans, managing budgets, and fostering strong customer relationships. Collaborate with cross-functional teams to optimize perfo...
1 week ago
Director, Patient Intelligence Strategy & Governance
$185K - $344K *
Advance enterprise patient intelligence by leading strategy, governance, and analytics. Collaborate across functions to enhance decision-making and drive insights that improve patient outcomes and bus...
2 days ago
Group Project Manager, Healthcare and Pharmaceutical Advertising
$120K - $150K *
Lead complex project management initiatives across multiple channels in the pharmaceutical advertising sector. Oversee cross-functional teams, ensuring timely delivery within budget while mentoring ju...
1 week ago
Principal Product Quality Leader
$138K - $187K *
Lead cross-functional quality initiatives to enhance product health and compliance. Collaborate with diverse teams on regulatory submissions, quality assessments, and process improvements for late-sta...
Yesterday
Senior Clinical Trial Manager (CTM)
$168K - $188K *
Oversee and manage clinical trials from protocol development to final report, ensuring compliance with GCP and regulatory standards. Collaborate with cross-functional teams to enhance research efficie...
Reposted 4 weeks ago
$90K - $100K *
Transform project management by leading client-sponsored trials, coordinating multidisciplinary teams, and ensuring timely delivery of objectives while fostering collaboration and communication across...
Yesterday
Associate Dean Academic Affairs - BSN Online Program Mentor
$70K - $142K *
Lead the charge in enhancing academic operations and faculty performance, ensuring compliance with accreditation standards while fostering student success through strategic curriculum development and...
3 weeks ago
AVP, Procurement Center of Excellence
$184K - $254K *
Shape the future of Procurement by leading enterprise capabilities that enhance performance, streamline processes, and drive technology integration, ensuring measurable value and strategic alignment a...
2 days ago
Lead Director - Digital Product (Causal Analytics)
$144K - $288K *
Empower product innovation by leading analytics development, defining strategies, and collaborating with cross-functional teams to enhance patient care and drive impactful solutions in a dynamic envir...
Reposted 1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.