Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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$110K - $130K *

Join a team that's redefining DME resupply operations by leading a global, remote call center. Drive revenue growth, optimize performance, and ensure compliance while managing a diverse workforce to e...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Lead quality oversight for drug manufacturing, ensuring compliance with cGMPs. Collaborate with vendors on batch record review and product disposition for global clinical programs, thriving in a dynam...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$122K - $204K *

Lead the charge in renewing and expanding customer relationships within complex healthcare environments. Leverage your expertise in the 340B program to drive strategy, enhance partnerships, and delive...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$205K - $380K *

Accelerate progress at enterprise sales by driving strategic growth initiatives, building relationships with healthcare leaders, and leading complex sales pursuits to enhance market presence and custo...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$185K - $215K *

Drive the development of Contract Financials, collaborating with cross-functional teams to enhance value-based care products. Own the roadmap, prioritize client needs, and ensure successful feature de...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Drive operational excellence by leading Hub programs, enhancing performance metrics, and developing Supervisors. Collaborate cross-functionally to ensure effective service delivery and continuous impr...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$170K - $200K *

Empower a high-growth organization by leading operations strategy, enhancing client satisfaction, and driving efficiency through AI and automation. Collaborate with senior leadership to ensure financi...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Develop and lead regional strategies to drive product launch success, ensuring alignment with corporate goals. Build a high-performing team, foster customer relationships, and execute data-driven deci...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$176K - $294K *

Contribute to building impactful relationships with Hematology thought leaders, crafting engagement strategies and insights to optimize Pfizer’s Hematology portfolio. Collaborate cross-functionally to...

RemoteRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$227K - $341K *

Lead the strategic development and continuous improvement of clinical programs, focusing on optimizing patient care across the continuum. Oversee a multidisciplinary team to enhance outcomes, reduce h...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$280K - $350K *

Lead the charge in providing exceptional medical care and patient education. Collaborate with a dedicated team to assess, diagnose, and treat patients, ensuring adherence to safety standards and quali...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Innovate data-driven product strategies by leading informatics initiatives, ensuring rigorous testing and quality assessments while collaborating across teams to enhance client services and streamline...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$150K - $230K *

Unlock potential by driving oncology product success through strategic relationships and innovative solutions. Collaborate with healthcare professionals to enhance patient access and exceed performanc...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Elevate regional sales performance by leading a high-performing team, executing launch strategies, and fostering customer relationships in a dynamic environment. Drive accountability and collaboration...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$134K - $219K *

Lead clinical laboratory operations for precision medicine projects, ensuring timely deliverables and risk management across therapeutic areas. Collaborate with cross-functional teams to support clini...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Unlock growth potential by managing strategic accounts and cultivating executive relationships. Drive revenue through tailored strategies and consultative selling, while aligning cross-functional team...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$207K - $346K *

Lead the charge in evidence-based medical case reviews to ensure high-quality patient care while collaborating with a network of over 500 physician colleagues in a fully remote environment...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$58K - $105K *

Unlock your potential by managing the full contracting lifecycle, supporting critical agreements for Medicare Advantage and Commercial operations, while collaborating with diverse teams to enhance com...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$133K - $178K *

Advance R&D financial strategies by leading planning, reporting, and analysis. Collaborate across teams to evaluate investments and enhance financial processes, ensuring informed decision-making and o...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $170K *

Join a team that's transforming drug development through data science. Leverage your expertise to build predictive models and analytics, driving process improvements and technology transfer in a colla...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Drive data integrity and operational excellence by resolving complex payer data issues, collaborating across teams, and enhancing data quality for value-based care initiatives. Play a key role in opti...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$139K - $188K *

Unlock potential by leading regulatory writing for complex submissions, mentoring junior writers, and driving departmental initiatives. Collaborate with cross-functional teams to ensure compliance and...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Elevate member care by facilitating seamless transitions from hospital to home. Collaborate with healthcare teams to ensure safe discharges, reduce readmissions, and provide comprehensive support thro...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$99K - $118K *

Transform your career by leveraging your clinical and coding expertise to defend appeals for healthcare claims. This role demands independent analysis, strong communication, and proficiency in AI tool...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$162K - $195K *

Shape the future of cardiovascular care by driving the launch of a novel cardiac myosin inhibitor. Collaborate with healthcare professionals and internal teams to establish strategic relationships and...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.