Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Advisor, Regulatory Starting Material
$153K - $268K *
Join a team that's advancing regulatory strategies for drug substance manufacturing. Lead the charge in selecting and justifying Regulatory Starting Materials, ensuring compliance with global guidelin...
Reposted 1 week ago
Medical Director (Publications)
$130K - $150K *
Champion effective publication strategies and lead scientific communication initiatives, acting as a strategic partner to clients and teams. Navigate complex medical affairs content to drive impactful...
Reposted 1 week ago
General Manager, Multi-Site Pharmacy Operations
$100K - $120K *
Optimize multi-site pharmacy operations by overseeing daily workflows, staffing, and performance metrics. Collaborate with leadership and Pharmacists-in-Charge to ensure compliance and efficiency acro...
2 weeks ago
Pharmacist Full Relocation Package Available
$100K - $120K *
Join a team that's dedicated to providing exceptional pharmacy services, ensuring patient safety, and delivering clinical healthcare. Collaborate with a supportive team while mentoring others and stay...
1 week ago
Counsel, Regulatory (Pharmacy)
$120K - $145K *
Join a dynamic Legal team to provide actionable regulatory advice across pharmacy laws, impacting healthcare and e-commerce. Collaborate with diverse business units to navigate complex legal landscape...
Today
Certified Physician Assistant/ Certified Nurse Practitioner
$85K - $100K *
Inspire your career with a role supporting physicians and enhancing patient recovery through hands-on medical care, assessments, and collaboration in a dynamic healthcare environment...
Reposted 2 weeks ago
Executive Director, Sales - West
$295K - $325K *
Drive strategic sales leadership across the Western US, translating brand vision into effective field execution. Build and sustain a high-performing team while collaborating cross-functionally to achi...
Yesterday
Supervisor Pharmacy | Cancer Care Institute
$85K - $100K *
Unlock potential by managing pharmacy operations, supervising staff, and ensuring compliance. Cultivate leadership crucial for team growth and efficient workflow while delivering exceptional patient c...
Reposted 2 weeks ago
Director, Clinical Systems Operations (Pharmacy)
$134K - $249K *
Lead the charge in enhancing clinical systems operations, driving efficiency and effectiveness across pharmacy initiatives while managing a dedicated team and overseeing complex workflows and data int...
Today
$125K - $150K *
Engage with a talented team to drive growth and innovation in pharma sales. Own the sales cycle from strategic prospecting to closing high-impact deals, while developing key relationships that enhance...
Reposted 3 weeks ago
$120K - $145K *
Lead the charge in advancing enterprise automation capabilities, driving quality engineering innovation, and influencing strategic decisions across a rapidly growing organization, enhancing software r...
Reposted 1 week ago
Director of Active Ingredient Supply (GCS)
$125K - $150K *
Transform supply chain operations by leading procurement, inventory management, and cash planning. Collaborate with cross-functional teams to ensure product delivery, regulatory compliance, and contin...
Yesterday
$195K - $244K *
Unlock your potential as a Global Regulatory Leader, driving regulatory strategy and submissions for CNS projects. Collaborate with cross-functional teams, mentor junior staff, and ensure compliance w...
3 weeks ago
Senior Managing Counsel-Pharmacy Network Operations
$197K - $328K *
Shape the future of pharmacy network operations by leading a team of attorneys, providing strategic legal counsel on regulatory, operational, and transactional matters within the PBM landscape, while...
Reposted 6 days ago
Director, Clinical Pharmacology
$189K - $246K *
Lead clinical pharmacology strategies, integrating PK/PD assessments across development phases. Collaborate with cross-functional teams to guide decision-making and regulatory submissions, ensuring al...
Today
$120K - $162K *
Drive pharmacy operations as a licensed Pharmacist, ensuring compliance, safety, and exceptional customer care. Lead a dedicated team while managing workflow, performance metrics, and process improvem...
Reposted 4 weeks ago
Conditions Subscriptions Director
$218K - $350K *
Shape the future of healthcare by leading our subscription business, driving growth and innovation. Collaborate across teams to enhance customer experience and optimize performance, ensuring alignment...
3 weeks ago
Clinical Supply Chain Site Lead
$110K - $130K *
Champion the clinical supply chain for late-stage oncology trials, ensuring seamless operations and communication between sites, suppliers, and stakeholders. Drive continuous improvement and complianc...
6 days ago
$80K - $95K *
Lead market expansion and provider relationships through consultative sales strategies, driving revenue growth and pipeline management within a dynamic healthcare environment while leveraging AI tools...
Reposted 1 week ago
Director Commercial Compliance
$119K - $186K *
Lead the development of a risk-based compliance framework for U.S. pharmaceutical commercialization, advising senior leaders and ensuring adherence to compliance standards while fostering ethical deci...
2 weeks ago
Medical Affairs Technology and Digital Innovation Director
$190K - $238K *
Transform your career by leading the digital strategy for Medical Affairs. Drive innovation, optimize processes, and enhance scientific communications through emerging technologies while collaborating...
1 week ago
Lead Clinical Pharmacist, Oncology Programs
$120K - $145K *
Join a team that's redefining oncology care by overseeing clinical standards, evaluating therapies, and engaging with providers. You'll play a key role in shaping patient eligibility and treatment pro...
3 weeks ago
$150K - $235K *
Join a team that's shaping the future of Medical Affairs by driving strategic client engagements and enhancing capabilities. This Director-level role balances client delivery and internal growth, focu...
3 weeks ago
Director, Copay & Affordability
$199K - $269K *
Shape patient affordability strategies by leading a dynamic team focused on co-pay programs and innovative solutions. Collaborate cross-functionally to enhance operations, optimize performance, and dr...
Reposted 3 days ago
$115K - $130K *
Unlock potential by driving data analysis and interpreting clinical trial results. Collaborate with stakeholders, ensure statistical integrity, and contribute to innovative methodologies in biostatist...
Reposted 3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.