Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Asset Lead Medical Director - Obesity and Related Conditions
$217K - $294K *
Innovate the U.S. Cardiovascular & Metabolic Medical strategy, leading evidence generation and stakeholder engagement for chronic weight management. Collaborate cross-functionally to ensure launch rea...
Today
NeuroPsych Account Specialist - Hawaii HI
$123K - $168K *
Explore the potential of Neurocrine products by managing key accounts, driving sales growth, and fostering relationships with healthcare professionals. Collaborate cross-functionally to enhance produc...
3 weeks ago
$195K - $217K *
Drive client success by leading strategic initiatives and fostering strong relationships in healthcare technology. Leverage deep domain expertise to enhance outcomes and ensure effective use of soluti...
1 week ago
Manager, Nonsterile Production Planning
$110K - $130K *
Transform production planning by leading a dynamic team to optimize non-sterile compounded production. Drive strategic planning, manage capacity, and ensure alignment with demand forecasts while foste...
6 days ago
Product Manager - Vendor Oversight
$113K - $197K *
Lead the charge in defining product strategy and roadmap, translating business objectives into actionable plans. Collaborate with cross-functional teams to ensure successful implementation and operati...
1 week ago
$80K - $95K *
Empower growth by developing strategic relationships with biotech and pharma clients. Drive market awareness and increase RFPs through collaboration with the business development team, leveraging your...
1 week ago
Senior Regulatory Affairs Specialist
$110K - $130K *
Shape the future of health technology by driving regulatory strategies for innovative lab testing, imaging, and AI products. Collaborate with cross-functional teams to ensure compliance and accelerate...
6 days ago
Associate Director, Field Medical Affairs-Hematology (TN, AL, MS, AR)
$176K - $287K *
Engage with KOLs and HCPs to share scientific data on B-Cell Malignancies. Collaborate with researchers and decision-makers to drive medical strategy and support clinical trials, contributing to impac...
3 weeks ago
$100K - $120K *
Transform patient safety operations by leading a dedicated team, ensuring compliance, and enhancing pharmacovigilance processes. Collaborate cross-functionally to deliver high-quality safety services...
Today
Internal Medicine or Family Medicine Physician
$241K - $337K *
Transform your career with a flexible role in primary care, serving a diverse patient population. Collaborate with a dedicated team in a supportive environment, offering both part-time and full-time o...
3 weeks ago
Director, Global Regulatory Project and Submission Management
$176K - $236K *
Lead the charge in global regulatory project management, driving oncology strategies and submissions across regions. Collaborate with cross-functional teams to ensure compliance and timely market acce...
Today
Professional (Senior) Sales Representative, Pain - Memphis S, TN
$100K - $162K *
Unlock potential by driving sales success in a defined territory, cultivating client relationships, and executing strategic plans to meet sales goals while adhering to ethical practices in the pharmac...
Reposted 3 weeks ago
$150K - $180K *
Join a pioneering team to build an AI-enabled care delivery platform, bridging clinical expertise and engineering to create safe, effective patient care solutions. Drive innovation from concept to pro...
3 weeks ago
Audit Policy Analyst, Post-Acute Services
$80K - $95K *
Innovate post-acute payment integrity by developing and optimizing audit concepts for DME, home health, and infusion therapy claims. Collaborate cross-functionally to ensure compliance and enhance ope...
1 week ago
Associate Director, Compliance
$110K - $130K *
Drive the enhancement of Compliance Monitoring and Testing programs, ensuring regulatory alignment and effective risk management. Collaborate with stakeholders to improve operational efficiency and su...
1 week ago
Field Reimburesement Manager - Pennsylvania
$185K - $230K *
Elevate community access to innovative therapies by developing strategic reimbursement solutions, collaborating with stakeholders, and ensuring compliance with healthcare regulations while managing co...
1 week ago
Senior Director, European Regulatory Strategy Lead
$160K - $259K *
Champion regulatory excellence by leading European strategies for innovative therapies. Drive successful submissions and interactions with health authorities, ensuring compliance and alignment across...
2 weeks ago
Professional (Senior) Sales Representative, Pain - Saint Louis S, MO
$100K - $162K *
Drive territory growth by developing strategic business plans and delivering tailored sales presentations to foster customer relationships while achieving sales targets and maintaining ethical standar...
Reposted 3 weeks ago
$213K - $243K *
Champion the development of a robust commercial data strategy, ensuring high-quality, AI-ready data solutions that drive impactful decision-making and enhance commercial performance across the organiz...
2 weeks ago
Regional Sales Director - Memphis
$180K - $215K *
Lead the charge in regional sales execution, driving product launch success and team performance through strategic planning, customer engagement, and cross-functional collaboration in a dynamic enviro...
1 week ago
21GRAMS- Associate Creative Director, Copy
$160K - $180K *
Unlock potential by leading creative engagements across healthcare accounts. Drive innovative campaigns, mentor teams, and manage client relationships while delivering impactful narratives that resona...
3 days ago
$112K - $132K *
Join a team that's shaping the future of autism care by building robust statistical methodologies. You'll analyze real-world clinical data, ensuring rigorous evaluation of outcomes and social validity...
2 days ago
Senior Director, Global Revenue Accounting and Order to Cash
$234K - $322K *
Transform global revenue accounting and order-to-cash processes in a dynamic healthcare environment. Lead a high-performing team, ensuring compliance with U.S. GAAP and driving systems improvements fo...
1 week ago
Managing Consultant, Life Sciences Technology Consulting - Patient Services
$130K - $216K *
Join a dynamic team to lead technology consulting projects in biopharma, ensuring successful implementation of patient services solutions. Collaborate with clients and cross-functional teams to drive...
1 week ago
$198K - $297K *
Engage in a dynamic role that empowers team collaboration and drives results in a leading organization recognized for innovation and excellence in performance, fostering an environment of growth and p...
Reposted 2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.