Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
VP, Payer Sales - National Accounts
$160K - $172K *
Elevate your career by driving growth in national health plan accounts. Leverage your expertise to build relationships, negotiate complex deals, and exceed revenue targets while collaborating with cro...
2 weeks ago
Account Specialist (Boston, MA)
$160K - $192K *
Deliver exceptional sales and support within the healthcare sector, building productive relationships with providers while driving product adoption and ensuring patient access to innovative therapies...
1 month ago
Thought Leader Liaison, US Oncology, South
$167K - $300K *
Unlock your potential by leading regional oncology thought leader engagement and advocacy strategies. Collaborate with cross-functional teams to shape brand strategy and launch planning for innovative...
3 days ago
$195K - $325K *
Join a team that's shaping the future of AI in healthcare by leading multi-year strategies, resolving complex technical challenges, and influencing executive decisions across the organization to ensur...
2 days ago
$142K - $168K *
Transform client experiences by leveraging deep expertise in healthcare solutions. Lead strategic initiatives, enhance client relationships, and drive impactful outcomes for high-value accounts throug...
1 week ago
Account Executive, HME Provider Sales
$80K - $100K *
Join a team that's driving growth by acquiring new customers and enhancing revenue through innovative solutions. Manage the full sales cycle while collaborating with cross-functional teams to ensure e...
3 days ago
Director, Field Reimbursement (FRM)
$210K - $250K *
Empower a dynamic team of reimbursement professionals to enhance provider access and education. Drive strategic initiatives, foster collaboration, and ensure compliance while navigating complex payer...
Today
AVP/VP, Client Services (RadScience)
$175K - $205K *
Transform client relationships and drive growth by leading strategic initiatives in scientific visualization, medical education, and digital engagement. Manage multidisciplinary teams and oversee acco...
Reposted 1 week ago
Associate Director, Early Patient Engagement & Professional Societies
$145K - $195K *
Unlock patient engagement strategies by integrating insights into drug development. Collaborate with diverse teams to generate evidence, engage with professional societies, and lead initiatives that p...
1 month ago
Clinical Informatics & Ontology Lead
$120K - $145K *
Lead the design and governance of clinical ontologies and terminology services, ensuring data quality and alignment with product needs. Collaborate cross-functionally to enhance data normalization and...
Today
$146K - $182K *
Design and deliver impactful training programs to enhance sales capabilities, ensuring alignment with corporate objectives. Collaborate with cross-functional teams to drive effective onboarding and co...
1 week ago
Director, Business Improvement
$150K - $180K *
Drive strategic initiatives and operational excellence across a global portfolio, partnering with leadership to enhance business performance and deliver measurable outcomes in oncology and rare diseas...
1 week ago
Senior Oncology Account Manager, San Antonio
$150K - $230K *
Elevate patient care by driving oncology product success through strategic relationships and innovative solutions. Lead efforts in territory management, market analysis, and collaborative engagement t...
1 week ago
Clinical Development Medical Director, Early Development - Cardiometabolic
$274K - $371K *
Lead the early phase clinical development of innovative therapeutics, collaborating across teams to design and execute trials. Your expertise will directly influence strategy, protocol development, an...
Reposted 1 week ago
Medical Review Nurse - Commercial DME Auditor
$80K - $95K *
Transform healthcare auditing by conducting thorough medical claims reviews. Collaborate with a dynamic team to ensure compliance and improve processes while working remotely in a fast-paced environme...
1 week ago
Associate Director, Access Strategy and Marketing
$177K - $221K *
Manage the strategy and execution of access marketing for oncology products, focusing on value propositions for payers and healthcare providers. Collaborate with cross-functional teams to ensure effec...
2 days ago
$120K - $145K *
Accelerate commercial growth by defining strategies for product families, collaborating across teams to translate market insights into actionable plans that drive revenue, profitability, and customer...
Today
Associate Director, Business Improvement
$130K - $160K *
Reimagine business improvement strategies as a senior contributor, leading high-impact initiatives across functions. Drive alignment, governance, and measurable outcomes while influencing stakeholders...
2 weeks ago
$80K - $96K *
Join a team that's dedicated to advancing anesthesiology practices, promoting CRNA autonomy in a supportive environment. Engage in diverse cases at a Level II trauma center while enjoying a flexible d...
3 weeks ago
$125K - $150K *
Lead a dynamic anesthesiology team in a Level II trauma center, ensuring high-quality patient care and promoting CRNA autonomy. Collaborate effectively with anesthesiologists while managing diverse ca...
3 weeks ago
Manager, Infrastructure Governance
$125K - $178K *
Accelerate progress at the forefront of cloud security governance, leading a dynamic team to enhance compliance, drive automation, and ensure robust risk management across multi-cloud environments...
Today
Physician, Internal Medicine - Telemedicine Opportunity - DrHouse
$210K *
Join a dynamic telemedicine team to deliver high-quality, patient-centered care across South Dakota. Enjoy flexible scheduling while managing diverse clinical cases, including primary and urgent care...
1 week ago
Director, Head of Patient Recruitment and Retention, Americas
$171K - $231K *
Drive innovative patient recruitment strategies to enhance clinical trial enrollment and retention. Collaborate with cross-functional teams to implement data-driven approaches, optimize patient engage...
Reposted 4 weeks ago
Director - Portfolio Valuation & Decision Analysis
$112K - $236K *
Drive strategic decision-making by evaluating investment alternatives and lifecycle opportunities. Collaborate with cross-functional teams to optimize portfolio value and support program planning thro...
1 week ago
Senior Product Manager, Marketplace Supply
$120K - $145K *
Accelerate progress at a dynamic marketplace by owning the Driver App, enhancing user experience, and driving engagement. Collaborate cross-functionally to optimize workflows and improve marketplace h...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.