Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Director, Counsel, Diagnostics & Medical Devices
$199K - $321K *
Join a dynamic team to provide strategic legal counsel on diagnostics and medical devices, ensuring compliance with FDA regulations and commercial strategies while collaborating across business units...
1 week ago
Clinical Development Medical Director, Obesity/Cardiovascular
$274K - $371K *
Elevate patient care through innovative clinical strategies in obesity and cardiometabolic development. Collaborate across teams to design and implement late-phase studies, ensuring alignment with glo...
Reposted 1 week ago
Director, Sales – Global Strategic Accounts
$150K - $180K *
Empower a high-performing sales team to drive strategic growth and customer engagement in the biopharma sector. Lead complex sales initiatives, build executive relationships, and translate business st...
Yesterday
Technical Implementation Specialist
$100K - $110K *
Drive the implementation and support of cutting-edge software solutions in Cell & Gene Therapy. Collaborate with diverse teams to translate customer needs into actionable plans, ensuring seamless inte...
3 weeks ago
Senior Director, Analytical Sciences
$215K - $240K *
Shape the future of drug development by leading analytical strategies, ensuring compliance and optimization of processes across lifecycle stages, and collaborating with cross-functional teams and exte...
4 weeks ago
Manager Regulatory Intelligence
$120K - $180K *
Shape the future of regulatory intelligence by leading cross-functional teams, managing global surveillance workstreams, and translating complex regulations into actionable insights for stakeholders a...
1 week ago
Medical Science Liaison, Central US (Multiple Territories)
$155K - $175K *
Empower healthcare professionals by delivering scientific insights and fostering relationships. Drive prelaunch and launch strategies in a dynamic environment, ensuring clinical readiness and impactfu...
2 weeks ago
Field Reimbursement Manager-Pacific
$185K - $230K *
Empower patient access by leading reimbursement strategies in rare diseases. Collaborate cross-functionally to navigate complex pathways, educate providers, and support patients, ensuring compliance a...
1 week ago
Assoc Dir, Neuro Thought Leader Liaison (Midwest Region)
$190K - $225K *
Transform relationships with key opinion leaders in rare neurological diseases, providing strategic insights and guidance to inform brand strategies and enhance engagement across medical and commercia...
Reposted 2 days ago
Director - AI Digital Product Management - Commercial Value & Access
$199K - $269K *
Grow your career with a leadership role in AI Digital Product Management, driving strategy and innovation across a portfolio of AI products. Collaborate with cross-functional teams to deliver scalable...
3 weeks ago
Senior Oncology Account Manager, Milwaukee
$150K - $230K *
Join a team that's dedicated to advancing oncology care by promoting innovative products and building strong relationships with healthcare professionals. Leverage your expertise to drive brand value a...
1 week ago
Senior Oncology Account Manager, Lansing
$150K - $230K *
Engage with key stakeholders to promote oncology products, build relationships, and drive brand value. Utilize market insights to develop effective strategies, ensuring patient access and compliance w...
1 week ago
Account Specialist, Eugene, OR
$160K - $192K *
Engage with healthcare providers to drive commercial performance and product adoption. Collaborate with cross-functional teams to support launches and optimize patient access, ensuring impactful relat...
1 week ago
Sr. Technical Product Manager, AI & Analytics
$116K - $193K *
Lead the charge in defining and executing the product strategy for AI and analytics, driving innovation across pharmacy management platforms. Collaborate with cross-functional teams to deliver scalabl...
3 weeks ago
Senior Oncology Account Manager, Pittsburgh
$150K - $230K *
Empower oncology practices by driving product adoption and building relationships with key stakeholders. Lead strategic initiatives to enhance patient access and optimize territory management while ex...
1 week ago
Senior Director, Clinical Operations
$270K - $280K *
Join a team that's driving clinical excellence by overseeing trial execution, managing timelines, budgets, and CROs. Collaborate with stakeholders to ensure compliance and quality while mentoring team...
2 weeks ago
Global Marketing Director, Oncology
$195K - $265K *
Transform global marketing strategies in oncology by leading cross-functional teams, driving insights, and optimizing brand value for pipeline assets. Collaborate with stakeholders to enhance commerci...
Today
Professional (Senior) Sales Representative, Pain - Trenton, NJ
$100K - $162K *
Drive sales growth by developing strategic business plans and forging strong customer relationships. Achieve targets through effective presentations while adhering to ethical standards and enhancing p...
Reposted 2 weeks ago
Remote Clinical Psychologist - Older Adults | PhD / PsyD | Telehealth
$80K - $100K *
Join a team that's dedicated to delivering high-quality psychotherapy to older adults. Enjoy flexible scheduling, comprehensive support, and the opportunity to make a meaningful impact in a collaborat...
4 weeks ago
Principal Scientist, Formulation Development
$170K - $190K *
Lead formulation development from discovery to clinical stages, translating compounds into scalable processes. Collaborate with cross-functional teams to drive strategy, solve challenges, and ensure q...
2 weeks ago
U.S. Director of Medical Affairs (US DMA) - Ophthalmology
$190K - $300K *
Transform medical affairs by driving scientific excellence and strategic initiatives in ophthalmology. Collaborate with cross-functional teams to enhance field readiness and optimize engagement across...
1 week ago
Chief of Staff to the SVP - Healthcare Analytics
$131K - $303K *
Join a team that's at the forefront of healthcare analytics, driving innovation and strategy. You will support financial stewardship, operational excellence, and executive communications in a high-vis...
Reposted 2 weeks ago
Public Health Analyst I (Vaccines)
$100K - $108K *
Unlock potential by providing essential data management and help desk support for public health initiatives, ensuring efficient operations and user assistance in a dynamic healthcare environment...
3 days ago
$110K - $118K *
Join a team that's driving strategic financial decisions by managing complex Treasury activities, analyzing risks, and enhancing operational efficiencies. Influence liquidity and banking relationships...
1 week ago
Senior Oncology Account Manager, Little Rock
$150K - $230K *
Join us to drive the promotion of innovative oncology products, build strong relationships with healthcare professionals, and exceed performance goals while ensuring patient access to vital treatments...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.