Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Medical Science Liaison, CNS - AR, LA, OK
$150K - $224K *
Advance patient outcomes by leveraging your expertise in CNS as a Medical Science Liaison. Collaborate with healthcare providers and stakeholders to deliver evidence-based insights and drive strategic...
Yesterday
VP, Sales - Global Client Services
$120K - $140K *
Transform global client relationships by driving revenue growth and strategic account management. Collaborate with C-suite executives to connect workplace culture and employee experience to measurable...
Yesterday
Senior Oncology Account Manager, Rochester
$150K - $230K *
Elevate oncology product promotion by building strong relationships with key stakeholders. Drive performance goals through effective marketing strategies and innovative solutions, ensuring timely acce...
1 week ago
Patient Marketing Manager - Epilepsy
$176K - $196K *
Transform patient engagement by leading innovative marketing strategies for relutrigine, enhancing the treatment journey for epilepsy patients and caregivers. Drive impactful initiatives through cross...
2 weeks ago
Staff Physician, Primary Care Telemedicine
$245K *
Partner with us to redefine virtual primary care, delivering exceptional patient services through innovative telehealth solutions. Join our dedicated team to enhance health accessibility and effective...
Reposted 3 weeks ago
$116K - $175K *
Join our team to oversee and enhance logistics operations for Dental products, ensuring efficient order fulfillment and distribution. Lead a dedicated team while collaborating with various departments...
1 week ago
Director, Regulatory Affairs, Advertising & Promotion (Remote)
$205K - $341K *
Unlock your potential by leading regulatory strategies for advertising and promotion. Collaborate with cross-functional teams to ensure compliance and drive successful commercialization initiatives in...
Yesterday
Associate Director, Regulatory Science
$177K - $221K *
Champion regulatory excellence by leading cross-functional teams, ensuring compliance, and driving successful oncology drug development through strategic planning and expert guidance...
1 week ago
Senior Oncology Account Manager, Dallas East
$150K - $230K *
Accelerate your career by driving oncology product success and building impactful relationships with healthcare professionals. Lead strategic initiatives to enhance patient access and deliver innovati...
1 week ago
Senior Oncology Account Manager, Detroit
$150K - $230K *
Transform the oncology landscape by driving product success and building strong relationships with key stakeholders. Leverage your expertise to enhance patient access and deliver innovative solutions...
1 week ago
$110K - $130K *
Join us to lead the development and execution of clinical study designs, ensuring effective project management and collaboration across teams. Your expertise will drive the success of clinical trials...
2 weeks ago
Account Specialist (Worcester, MA)
$160K - $192K *
Drive commercial performance by engaging healthcare providers and executing territory plans. Collaborate with cross-functional teams to support product launches and ensure patient access to innovative...
1 week ago
Senior Compliance Analyst (Compliance Oversight Activities) - Remote
$74K - $118K *
Elevate compliance standards by leading oversight initiatives, managing complex projects, and collaborating across teams to ensure regulatory adherence and effective governance in a dynamic environmen...
5 days ago
Professional (Senior) Sales Representative, Pain - Omaha, NE
$100K - $162K *
Join a team that's committed to driving sales success through strategic territory management and effective relationship building with healthcare professionals, ensuring high productivity and ethical s...
Reposted 3 weeks ago
Remote Clinical Psychologist - Older Adults | PhD / PsyD | PSYPACT | Telehealth
$100K - $120K *
Join a team that's redefining telehealth by delivering exceptional psychotherapy to older adults. Enjoy flexible hours, comprehensive support, and opportunities for professional growth while making a...
4 weeks ago
Territory Business Manager - Psychiatry - North & South Dakota
$125K - $155K *
Join a team that's driving sales success in the North & South Dakota territories. Leverage your expertise in pharmaceutical sales to educate healthcare providers and manage territory effectively, ensu...
2 weeks ago
Territory Business Manager - Psychiatry - North & South Dakota
$125K - $155K *
Elevate your career by driving sales and promoting innovative products in the North & South Dakota territories. Leverage your expertise to educate healthcare providers and manage territory effectively...
2 weeks ago
Regional Sales Director - Phoenix
$180K - $215K *
Transform regional sales performance by leading a high-impact team, executing strategic launches, and fostering key customer relationships in a dynamic, fast-paced environment. Drive accountability an...
1 week ago
Field Reimbursement Manager - Central
$110K - $130K *
Drive patient access to Provenge by removing reimbursement barriers and collaborating with healthcare stakeholders. Develop strategies to enhance business growth while navigating complex payer policie...
6 days ago
Executive Director Access Services - Immunology
$255K - $424K *
Lead the development and execution of Immunology access services strategy, ensuring seamless patient and provider experiences. Collaborate cross-functionally to enhance reimbursement initiatives and d...
3 days ago
Senior Oncology Account Manager, Raleigh
$150K - $230K *
Join a dynamic team as you manage oncology product promotions, build relationships with key stakeholders, and drive brand value through strategic engagement and innovative solutions in a competitive b...
1 week ago
Field Reimbursement Manager - Northern CA
$185K - $230K *
Shape the future of community access by developing strategies to optimize reimbursement processes, collaborating with stakeholders, and ensuring compliance with healthcare regulations while enhancing...
1 week ago
$108K - $135K *
Elevate your career by overseeing treasury operations, managing liquidity, and enhancing banking relationships. Collaborate with finance teams to align strategies with financial objectives, ensuring o...
1 week ago
Dir, MAPS (Market Access Patient Services)/Medical Data Partnerships Lead
$185K - $344K *
Join a team that's redefining market access through innovative data partnerships. Lead strategic collaborations, ensure data compliance, and drive insights that enhance decision-making and patient ser...
Reposted 6 days ago
Senior Product Manager- Informatics (IC)
$67K - $199K *
Elevate product strategy and execution for Epic EHR solutions, driving user-centric design and agile methodologies. Collaborate with stakeholders to enhance healthcare delivery through innovative info...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.