Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Bone Access & DMAB Patient Experience Lead, Marketing Senior Manager
$149K - $202K *
Make your mark at the forefront of patient access marketing, leading strategies and initiatives to enhance the Bone portfolio experience. Collaborate cross-functionally to optimize access solutions an...
6 days ago
Vice President, Clinical Operations
$200K - $250K *
Make your mark at the forefront of clinical operations, driving global studies from strategy to execution while ensuring operational integration across teams and vendors for successful Phase 3 program...
1 month ago
Vice President, CMC Regulatory Affairs
$272K - $340K *
Elevate your career by leading CMC Regulatory strategy and execution. Drive submissions, build a high-performing team, and engage with global health authorities to ensure compliance and success in dru...
1 week ago
Medical Science Liaison - Senior Medical Liaison - Mid Atlantic Region
$162K - $203K *
Champion scientific engagement by building relationships with key opinion leaders in Urology and Women's Health. Leverage expertise to support medical strategies and enhance product knowledge across t...
3 days ago
Account Specialist (Athens, GA)
$160K - $192K *
Drive commercial success by engaging healthcare providers and executing territory plans. Collaborate with cross-functional teams to support product launches and enhance patient access to innovative th...
5 days ago
Physician - Emergency Medicine
$210K - $250K *
Shape the future of emergency care by providing critical healthcare services in a dynamic environment. Collaborate with a multidisciplinary team to treat diverse patient needs, ensuring high-quality c...
3 weeks ago
Senior Medical Science Liaison, Neuroscience - New England Region
$151K - $237K *
Partner with us to advance medical strategy as a Medical Science Liaison, engaging with KOLs and HCPs, interpreting scientific data, and fostering expert networks to improve patient outcomes in a dyna...
2 weeks ago
$80K - $95K *
Drive revenue cycle optimization by enhancing Epic Professional Billing workflows, collaborating with stakeholders, and resolving claims challenges to improve overall operational efficiency and ensure...
4 weeks ago
$100K - $125K *
Champion the development of healthcare marketing tools by guiding cross-functional teams through the product lifecycle, driving innovative features and optimizing user experiences to enhance HCP engag...
Reposted 1 week ago
Senior Director Product Management
$172K - $287K *
Join us to shape the future of pharmacy by leading product strategy and innovation. Drive growth and commercialization for a diverse portfolio of healthcare technology solutions, influencing enterpris...
Reposted 1 week ago
$66K - $169K *
Lead product quality initiatives to ensure compliance and continuous improvement throughout the product lifecycle, partnering with cross-functional teams to enhance manufacturing performance and suppo...
Reposted 6 days ago
Associate Director, Field Reimbursement
$211K - $235K *
Drive patient access initiatives by leveraging oncology expertise to navigate reimbursement landscapes, educate stakeholders, and resolve complex access issues, ensuring timely therapy access for pati...
2 days ago
$180K - $220K *
Lead the sales strategy for a healthcare Payer business unit, driving market penetration, revenue growth, and client satisfaction. Collaborate with leadership to shape go-to-market strategies and buil...
Today
Professional (Senior) Sales Representative, Pain - Kansas City E, KS
$100K - $162K *
Develop business strategies to achieve sales targets in the assigned territory. Build relationships with customers and peers while adhering to ethical sales practices. Play a key role in driving produ...
Reposted 3 weeks ago
$250K - $286K *
Shape the future of sales by leading a dynamic team to drive new business, refine strategies, and enhance customer experiences in a fast-paced SaaS environment, while mentoring leaders and achieving a...
3 weeks ago
$92K - $153K *
Join a team that's dedicated to enhancing patient access by managing reimbursement challenges and providing education to healthcare providers. This role requires strong relationship-building skills an...
Today
Senior Manager, Regulatory Affairs
$120K - $145K *
Transform regulatory strategies for rare disease and cardio-pulmonary drug-device programs. Collaborate with cross-functional teams to ensure compliance and drive successful submissions globally, supp...
2 weeks ago
Senior Oncology Account Manager, Nashville
$150K - $230K *
Champion the promotion of oncology products, building strong relationships with healthcare professionals to enhance patient access and drive brand success in a competitive market. Leverage clinical ex...
1 week ago
Transactional Finance, Senior Associate
$101K - $137K *
Contribute to transactional finance activities across the procure-to-pay lifecycle, ensuring accurate processing of financial transactions while supporting operational workflows and maintaining data i...
1 week ago
Quality & Regulatory Technology & Innovation - Remote
$130K *
Partner with us to innovate and transform Quality & Regulatory operations through technology and data analytics. Drive automation, improve efficiency, and foster effective digital solutions that enhan...
Reposted 2 weeks ago
In-Home Health - Nurse Practitioner or Physician Assistant (Full Time) - Onondaga, NY
$95K - $206K *
Advance health outcomes by providing in-home evaluations, fostering trust and personalized care. Engage with patients to bridge gaps in health services, ensuring comprehensive support tailored to indi...
5 days ago
$136K - $187K *
Join a team that's dedicated to empowering patients with generalized Myasthenia Gravis through education and support. As a key point of contact, you'll coordinate care, provide resources, and ensure c...
1 week ago
Account Specialist (Lebanon, NH)
$160K - $192K *
Accelerate commercial success by engaging healthcare providers and driving product adoption. Collaborate with cross-functional teams to enhance patient access and support innovative therapies in a dyn...
1 week ago
eTailer Senior Account Manager, iHerb
$130K - $155K *
Accelerate progress at a leading eCommerce firm by driving global business strategy, overseeing P&L, and enhancing marketplace operations. Leverage your expertise in digital marketing and account mana...
Today
Sr. Medical Science Liaison- Appalachia Region
$166K - $205K *
Elevate your career as a Senior Medical Science Liaison, driving scientific exchange and collaboration with healthcare providers in oncology. Build relationships, support clinical initiatives, and con...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.