Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$110K - $130K *

Lead the charge in enhancing enterprise-wide Business Continuity programs, ensuring critical healthcare services remain uninterrupted. Collaborate across teams to strengthen resilience and deliver mea...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$95K - $115K *

Optimize chemical synthesis routes and develop new methodologies for key intermediates and APIs. Collaborate with teams to conduct multistep syntheses, ensuring product purity and compliance while mai...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$156K - $187K *

Transform the data landscape by designing and implementing robust integration solutions. Collaborate with cross-functional teams to enhance analytics infrastructure, ensuring seamless data flow and go...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$148K - $222K *

Pioneer advanced analytics strategies to optimize omnichannel investments, translating global performance data into actionable insights. Collaborate with cross-functional teams to drive measurable com...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$71K - $97K *

Transform patient care by guiding transitions and ensuring optimal service continuity. Leverage your nursing expertise to navigate healthcare options and advocate for patients in need of post-acute se...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Advance your career by leading medical writing projects in a regulatory environment. Collaborate with cross-functional teams to produce high-quality documents, ensuring compliance with industry standa...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $175K *

Champion the creation of high-quality regulatory documents, managing writing tasks and leading reviews. Collaborate across teams to ensure clarity and compliance, mentoring junior writers while delive...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $160K *

Champion the design and implementation of scalable data pipelines, ensuring data integrity and availability. Collaborate with cross-functional teams to optimize data workflows and enhance infrastructu...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$82K - $115K *

Transform the academic landscape by leading faculty development and student engagement. Drive excellence in teaching and support strategies while managing faculty performance and fostering a collabora...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$167K - $229K *

Lead the charge in transforming clinical decision-making strategies within health insurance, ensuring compliance and quality in medical reviews while advancing innovation in medical management and cro...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$103K - $192K *

Shape the future of healthcare reimbursement by leading analytics for payor contracting and out-of-network strategies. Collaborate with cross-functional teams to optimize financial outcomes and drive...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $165K *

Build and manage clinical stewardship operations, driving client success through effective program implementation and cross-functional collaboration. Leverage clinical expertise to enhance client rela...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $110K *

Transform the tax landscape by managing quarterly income tax reporting, compliance, and liaising with stakeholders. Drive efficiency in tax operations and support strategic initiatives in a dynamic, f...

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$82K - $85K *

Join a team that's dedicated to fostering student success through innovative teaching and clinical coordination. This dual role combines faculty responsibilities with hands-on clinical oversight, ensu...

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$180K - $220K *

Champion advanced clinical performance in managed care, leading teams to ensure quality, cost-effective member care. Leverage expertise in clinical oversight, policy development, and strategic decisio...

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$100K - $120K *

Join a team that's driving innovative marketing strategies to enhance brand growth and engagement. You'll lead a small team, manage multi-channel campaigns, and collaborate with operations to elevate...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$135K - $145K *

Partner with us to elevate healthcare communications by crafting compelling copy for HCP campaigns. Lead creative initiatives, collaborate with cross-functional teams, and ensure brand consistency acr...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$78K - $156K *

Join a team that's dedicated to enhancing business systems through design, configuration, and support. As a Senior Application Analyst, you'll lead improvements, mentor junior analysts, and ensure sea...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Lead strategic nursing initiatives across diverse ambulatory services, enhancing patient care, operational performance, and workforce engagement. Collaborate with executive leadership to drive quality...

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$105K - $158K *

Optimize financial performance by partnering with operations to enhance cost efficiency and profitability. Drive strategic investment decisions and support budgeting processes while ensuring alignment...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$176K - $287K *

Contribute to companion diagnostic strategy and development, leading programs from biomarker feasibility to clinical validation. Collaborate across teams to ensure diagnostics align with therapeutic m...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Drive financial accuracy and compliance as a Senior Accountant. Lead month-end close, maintain internal controls, and support auditors while refining processes. Ideal for proactive self-starters seeki...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$245K - $265K *

Shape the future of neurology by building partnerships with Medical Experts, driving insights, and collaborating across teams to enhance patient care and strategic initiatives in a dynamic healthcare...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$131K - $176K *

Oversee global Contract Manufacturing partnerships, driving productivity and ensuring quality goals are met. Collaborate cross-functionally to support new product launches and process improvements, wh...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K *

Drive new business growth by owning the full sales cycle in SMB and Mid-Market segments. Build relationships, strategize territory plans, and deliver compelling proposals to meet client needs while ex...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.