Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$150K - $214K *

Join a team that's redefining healthcare product management through innovative supply chain solutions. Lead cross-functional initiatives and shape the future of resilience in healthcare with strategic...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$78K - $106K *

Transform client payment policies by ensuring accuracy and compliance. Engage with internal and external teams to manage medical policy updates, conduct analyses, and enhance client relationships whil...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$229K - $310K *

Drive project management and business development to enhance operational efficiency in life sciences R&D, while leading diverse teams and ensuring profitability through strategic customer engagement a...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Healthcare

$129K - $162K *

Unlock potential by leading enterprise-wide Cost of Care solutions. Drive scalability, optimize deployment, and enhance operational effectiveness across diverse markets, collaborating with stakeholder...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$112K - $154K *

Lead the development and maintenance of Pharmacovigilance Risk Management Plans, ensuring pivotal safety documentation and compliance with global regulatory standards through collaboration and strong...

RemoteRemote

1 month ago

  •   Less than 5 years exp.  •   Healthcare

$105K - $202K *

Create innovative AI-powered healthcare products by transforming complex workflows into intuitive applications. Collaborate with cross-functional teams to deliver impactful user experiences and own fe...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$133K - $191K *

Transform revenue cycle operations by leading strategic initiatives, optimizing performance, and fostering collaboration across business units to enhance service delivery and achieve organizational go...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$70K - $100K *

Drive your career as a key Sales Executive, responsible for new client acquisition and expanding our innovative staffing services in the US market. Join a dynamic team where your expertise in building...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Staffing

$110K - $130K *

Join a team that's dedicated to advancing hematology care by educating healthcare providers and driving demand for innovative therapies. Leverage your expertise to foster relationships and ensure a po...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Analyze and optimize workforce management strategies across multiple business lines, translating complex forecasts into actionable capacity plans and financial models while collaborating with executiv...

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3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$180K - $220K *

Transform global in vitro scientific operations by leading expansive teams and driving innovation across oncology and immunology studies. Ensure operational excellence, harmonize multi-site workflows...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$195K - $215K *

Lead the charge in brand strategy, inspiring teams and fostering innovative solutions in a dynamic healthcare advertising environment, focused on advancing compelling communications and effective clie...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$157K - $174K *

Elevate technical execution in GMP manufacturing by leading complex workstreams for comparability strategies, tech transfers, and process improvements. Collaborate with cross-functional teams to ensur...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$86K - $135K *

Accelerate progress at driving sales growth by managing key accounts, pursuing new opportunities, and collaborating with cross-functional teams to deliver exceptional customer results in the specialty...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$110K - $166K *

Lead the charge in managing site contract negotiations and agreements, ensuring alignment with clinical study timelines. Collaborate with cross-functional teams to enhance contract processes and mento...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $167K *

Unlock potential by driving revenue insights and financial modeling, enhancing decision-making across finance and operations. Collaborate with stakeholders to refine processes and improve revenue reco...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$250K - $300K *

Oversee and deliver exceptional diagnostic imaging services remotely, focusing on evening shifts. Collaborate within a dynamic team while managing varied inpatient and outpatient cases to support pati...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $135K *

Lead the charge in operational excellence by developing managers and driving efficiency across multiple departments, ensuring safety, quality, and performance while fostering a culture of engagement a...

1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$220K - $255K *

Shape the future of healthcare by leading strategic payor relationships and driving reimbursement strategies. Collaborate cross-functionally to enhance patient access and optimize coverage for innovat...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Help us drive business development in oncology by leading strategic partnerships and optimizing resources to enhance clinical outcomes and market potential for our innovative diagnostic and therapeuti...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$160K - $190K *

Champion the development and oversight of scientific content across diverse therapeutic areas while managing client relationships and brand strategy for multiple accounts, ensuring high-quality and im...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$90K - $110K *

Manage patient care as an Advanced-Practice Provider in a collaborative team, leveraging a large referral network and comprehensive benefits to enhance the well-being of patients in a supportive envir...

4 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$95K - $115K *

Optimize supply planning for finished goods, driving process improvements and inventory management while collaborating with cross-functional teams to meet sales and operational goals...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$75K - $90K *

Transform client objectives into impactful paid social strategies. Oversee campaign execution, optimize performance, and mentor junior team members while driving cross-functional collaboration to achi...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$235K - $270K *

Join a dynamic team to lead transformative improvements in global supply chain operations, focusing on logistics excellence and strategic initiatives that enhance service, cost efficiency, and operati...

RemoteRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.