Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$242K - $403K *

Lead global companion diagnostics strategy, integrating diagnostic plans with clinical development and regulatory objectives. Drive execution across therapeutic programs, ensuring alignment with patie...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$132K - $199K *

Join a team that's committed to transparency in clinical trials, ensuring compliance with global disclosure regulations. This role blends operational and strategic tasks, fostering collaboration and q...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $192K *

Join us to drive commercial performance by engaging healthcare providers, building relationships, and supporting product launches. Your expertise will enhance patient access to innovative therapies an...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$175K - $210K *

Unlock potential by leading HEOR strategy and AI integration, ensuring project success and client satisfaction. Drive business growth, mentor teams, and influence health policy through innovative rese...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Accelerate progress at the forefront of rare disease management by collaborating with key stakeholders to enhance patient access and streamline treatment pathways across health systems and specialty c...

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$162K - $195K *

Drive sales performance by launching a novel cardiac myosin inhibitor, building strategic relationships with healthcare providers, and delivering impactful solutions to meet patient needs in your terr...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$165K - $190K *

Drive operational excellence in Medical Affairs by managing processes, timelines, and cross-functional coordination to ensure timely execution of strategic initiatives while maintaining compliance and...

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$275K - $350K *

Lead the charge in transforming operations by integrating AI and technology to enhance member and clinician experiences, ensuring efficient care delivery and operational excellence across a distribute...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$78K - $107K *

Drive financial integrity by managing complex accounting tasks, preparing reports, and influencing departmental strategy. Collaborate with teams to ensure compliance and accuracy while providing valua...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$87K - $157K *

Unlock compliance excellence by managing auditing, monitoring, and reporting processes to ensure adherence to regulatory standards and enhance operational efficiency across contracts and collaboration...

RemoteRemote

1 month ago

  •   Less than 5 years exp.  •   Healthcare

$232K - $348K *

Elevate customer understanding by leading analytics teams to deliver actionable insights that drive strategic decisions and enhance customer experiences across diverse markets and stakeholders...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Accelerate the deployment of innovative manufacturing processes for oncology products, ensuring compliance and collaboration across teams. Lead technology transfers and facility readiness to enhance p...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$210K - $250K *

Deliver comprehensive case reviews and clinical guidance, ensuring regulatory compliance and optimal patient outcomes. Collaborate with healthcare teams across multiple states to enhance service quali...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Join a team that's redefining DME resupply operations by leading a global, remote call center. Drive revenue growth, optimize performance, and ensure compliance while managing a diverse workforce to e...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Lead quality oversight for drug manufacturing, ensuring compliance with cGMPs. Collaborate with vendors on batch record review and product disposition for global clinical programs, thriving in a dynam...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$122K - $204K *

Lead the charge in renewing and expanding customer relationships within complex healthcare environments. Leverage your expertise in the 340B program to drive strategy, enhance partnerships, and delive...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$205K - $380K *

Accelerate progress at enterprise sales by driving strategic growth initiatives, building relationships with healthcare leaders, and leading complex sales pursuits to enhance market presence and custo...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$185K - $215K *

Drive the development of Contract Financials, collaborating with cross-functional teams to enhance value-based care products. Own the roadmap, prioritize client needs, and ensure successful feature de...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Drive operational excellence by leading Hub programs, enhancing performance metrics, and developing Supervisors. Collaborate cross-functionally to ensure effective service delivery and continuous impr...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Join a team that's dedicated to advancing NMR technology and research. Oversee facility operations, manage user access, and provide expert support to a diverse group of researchers while ensuring safe...

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$170K - $200K *

Empower a high-growth organization by leading operations strategy, enhancing client satisfaction, and driving efficiency through AI and automation. Collaborate with senior leadership to ensure financi...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Develop and lead regional strategies to drive product launch success, ensuring alignment with corporate goals. Build a high-performing team, foster customer relationships, and execute data-driven deci...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$176K - $294K *

Contribute to building impactful relationships with Hematology thought leaders, crafting engagement strategies and insights to optimize Pfizer’s Hematology portfolio. Collaborate cross-functionally to...

RemoteRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$227K - $341K *

Lead the strategic development and continuous improvement of clinical programs, focusing on optimizing patient care across the continuum. Oversee a multidisciplinary team to enhance outcomes, reduce h...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Innovate data-driven product strategies by leading informatics initiatives, ensuring rigorous testing and quality assessments while collaborating across teams to enhance client services and streamline...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.