Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$350K - $400K *
Optimize enterprise sales growth by leading a high-performing team, refining strategies, and driving revenue. Collaborate across departments to enhance processes and ensure long-term success in a dyna...
3 days ago
$120K - $190K *
Empower project success by managing sales opportunities, creating piping layouts, and fostering strong customer relationships. Utilize your engineering expertise to navigate complex situations and del...
2 weeks ago
Senior Manager, Evidence & Insights (RWE & HEOR)
$90K - $110K *
Join a team that's shaping evidence strategies and insights in health economics and outcomes research. Lead client engagements, oversee analytics, and drive impactful decision-making in biopharma and...
Yesterday
Principal Analytics Engagement Consultant
$162K - $214K *
Elevate analytics standards by leading rigorous data practices, ensuring quality, and guiding diverse teams to provide actionable insights. Collaborate with executives and present findings to influenc...
Reposted 3 weeks ago
$204K - $327K *
Drive innovative legal solutions as a key partner for AI and product teams, providing comprehensive guidance on regulatory challenges and product development. Collaborate cross-functionally to ensure...
Yesterday
Solution Architect (P&C insurance domain)
$135K - $160K *
Lead the charge in architecting a cutting-edge Commercial Lines insurance platform, focusing on microservices and event-driven architecture. Collaborate with cross-functional teams to define and deliv...
Yesterday
Onsite Patient Monitoring Project Manager - Georgia/Alabama
$90K - $110K *
Elevate patient care by leading project management for healthcare solutions. Drive implementation, ensure customer satisfaction, and coordinate resources while managing multiple projects in a dynamic...
6 days ago
Principal Strategic Researcher
$173K - $290K *
Join a team that's redefining strategic research by tackling complex, ambiguous challenges. Collaborate with product, design, and engineering leaders to shape impactful insights that drive business de...
2 weeks ago
Senior Product Manager, Enterprise Solutions
$174K - $218K *
Reimagine healthcare by shaping partnerships that drive innovative virtual-first care solutions. As a Senior Product Manager, you will bridge product and commercial teams, enhancing member engagement...
Reposted 4 weeks ago
Associate Vice President, Clinical Services - Market Access Marketing
$180K - $220K *
Lead the charge in developing clinical content strategies and overseeing teams within the market access practice. Drive innovation, enhance client strategies, and ensure high standards in service deli...
Reposted 3 weeks ago
$108K - $180K *
Transform pharmacy services by driving strategic initiatives and cross-functional projects. Collaborate with stakeholders, analyze outcomes, and mentor team members while shaping the future of pharmac...
4 weeks ago
Senior Clinical Database Programmer - eCOA
$110K - $140K *
Champion the design and execution of eCOA studies, ensuring compliance and data integrity. Collaborate with cross-functional teams to deliver high-quality clinical outcomes while managing multiple pro...
Yesterday
Account Specialist (Peachtree City, GA)
$160K - $192K *
Drive commercial performance by engaging healthcare providers and executing territory plans. Collaborate with cross-functional teams to support product launches and ensure patient access to innovative...
5 days ago
Technical Architect – Appian & Salesforce Platforms
$172K - $210K *
Architect and lead customer-focused application development initiatives, translating business needs into robust software solutions. Leverage modern technologies and AI tools to ensure high-quality, se...
1 week ago
$100K - $120K *
Support public health initiatives by managing community grant portfolios, providing technical assistance, and enhancing local coalitions' capacity to prevent youth substance use. Collaborate with stak...
Yesterday
Director - Professional Coding (Remote)
$190K - $252K *
Join a team that's redefining professional coding leadership, overseeing coding operations, quality audits, and education initiatives. Drive strategic objectives that enhance patient care and revenue...
Today
Business Performance Manager, Human Genetics
$104K - $141K *
Lead the charge in transforming Human Genetics strategy into actionable plans, ensuring measurable progress across R&D. Collaborate with cross-functional teams to align priorities and drive successful...
Today
$144K - $173K *
Shape the future of pharmaceutical media by leading client strategy and integrated media delivery. Drive audience engagement, manage high-impact relationships, and leverage data insights to achieve me...
2 weeks ago
$127K - $165K *
Unlock potential by leading regulatory strategies for innovative medical devices. Collaborate with teams to ensure compliance, execute FDA submissions, manage project timelines, and establish processe...
Reposted 5 days ago
Physical Therapist Home Health
$80K - $95K *
Elevate patient care by developing tailored rehabilitation plans, performing evaluations, and delivering effective treatments. Collaborate with a dedicated team to enhance patient outcomes and ensure...
2 weeks ago
$80K - $95K *
Drive the future of finance data analysis by ensuring accuracy and usability of financial data. Collaborate with finance and data teams to enhance reporting processes and validate data integrity for i...
1 week ago
Manager, Global Supply Chain Capabilities
$114K - $154K *
Transform supply chain operations by managing SAP systems and processes, ensuring seamless logistics and distribution support. Drive efficiency and issue resolution across Commercial and Clinical Supp...
Today
$242K - $282K *
Lead the oversight of contractual matters across departments, serving as a trusted advisor to internal stakeholders from pre-clinical to commercial readiness. This role emphasizes collaboration and ex...
Reposted 3 weeks ago
$94K - $136K *
Transform financial insights into strategic decisions by providing advanced analytical support across Finance, Operations, and Strategic Planning. Collaborate with leadership to drive impactful projec...
1 week ago
Account Specialist, Needham, MA
$160K - $192K *
Join a dynamic team to drive commercial performance and enhance patient access. Engage healthcare providers, support product launches, and collaborate with cross-functional partners to achieve sales g...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.