Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Oncologist Jobs in South Dakota

Sort By: Relevance

$135K - $160K *

Lead the charge in scaling our Customer Success Management team, driving product adoption and retention across diverse customer segments. Collaborate cross-functionally to create impactful processes a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$100K - $120K *

Shape the future of technical proposals by collaborating with cross-functional teams to create compelling, scientifically accurate documents that meet client needs and drive business success in the li...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$148K - $237K *

Champion the growth of our AI-driven Savings product by leading strategy, ideation, and execution. Collaborate across teams to enhance financial health solutions that significantly impact user retenti...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$160K - $200K *

Help us drive regional performance and market adoption by leading a high-performing sales team in the ophthalmic surgical industry. Your strategic vision and execution will be key to expanding our inn...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $190K *

Join a dynamic team as a Criticality Analysis & Nuclear Safety Engineer, responsible for ensuring nuclear safety in advanced fuel fabrication. Collaborate across disciplines to develop safety analyses...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$147K - $192K *

Tackle new opportunities in the healthcare sector by driving sales and strategy. Engage with C-suite executives, implement effective sales policies, and analyze market trends to maximize revenue growt...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Healthcare

$181K - $291K *

Lead the charge in managing the full systems development lifecycle for enterprise applications, ensuring data quality and integrity while evolving best practices across healthcare operations and suppo...

RemoteRemote

2 days ago

  •   11 - 15 years exp.  •   Healthcare

$100K - $130K *

Develop and implement business rules for credit strategy, collaborating with Risk, Compliance, and Tech teams. Ensure accurate decision logic, maintain documentation, and support testing for optimized...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Finance & Insurance

$115K - $158K *

Join us in driving strategic sales initiatives and optimizing operational performance. This role requires strong project management and analytical skills to enhance sales effectiveness and support mar...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$200K - $250K *

Join a team that's shaping growth strategies for Federal Civilian accounts. Leverage your expertise in federal markets to drive business development, capture opportunities, and enhance customer relati...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$75K - $105K *

Empower healthcare delivery by ensuring coding accuracy as you analyze medical records, identify improvement opportunities, and enhance AI diagnostic models to uphold high-quality standards in inpatie...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$170K - $230K *

Pioneer a high-performing sales team, driving revenue growth through strategic leadership and client engagement. Shape the future of our corporate sales efforts by optimizing processes and fostering c...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$215K - $408K *

Drive medical leadership in quality improvement and utilization management, ensuring effective care delivery and cost containment. Collaborate with clinical teams to enhance patient outcomes and suppo...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$77K - $121K *

Join a team that's redefining coding excellence by leading operational strategies, managing staff performance, and ensuring compliance in inpatient coding processes to enhance efficiency and quality a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$204K - $285K *

Innovate solutions for utility clients by leveraging your 15+ years of regulatory finance expertise. Lead projects, conduct cost studies, and provide expert testimony while mentoring junior staff and...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Energy & Utilities

$124K - $169K *

Drive strategic insights and analytics to enhance payer access and pricing strategies for biopharmaceutical products, ensuring optimal patient access in a complex healthcare landscape. Collaborate acr...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive go-to-market strategy for AI-powered healthcare solutions, collaborating cross-functionally to enhance product positioning, messaging, and performance. Own marketing execution and leverage insig...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $140K *

Drive impactful design solutions for developer tools, collaborating closely with engineers and PMs. Own workflows from discovery to delivery, enhancing user experiences and contributing to a robust de...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Elevate your career by leading trauma program initiatives in emergency services. Collaborate with multidisciplinary teams to enhance patient care and optimize operational efficiency in a fast-paced en...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$97K - $109K *

Join a team that's redefining customer engagement by providing technical expertise and tailored solutions during the pre-sales process. Collaborate with sales and services to ensure seamless transitio...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$177K - $279K *

Unlock potential by architecting customized applications using Conga Products. Lead end-to-end Quote-to-Cash implementations, enhancing operational efficiency and driving business transformation in co...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$170K - $180K *

Drive compliance and legal strategy in a pivotal role, advising leadership while managing risk, privacy, and governance across global operations. Leverage AI tools for efficiency and effectiveness in...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$182K - $252K *

Champion data-driven decision-making by leveraging deep analytics expertise to guide product, marketing, and finance leaders. Drive strategic insights and build innovative tools that enhance business...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$150K - $189K *

Lead the charge in developing and executing innovative marketing strategies for oncology products, collaborating with cross-functional teams to ensure successful launches and impactful customer engage...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$74K - $145K *

Lead the Claims operations team, ensuring timely processing and quality outcomes. Oversee staff performance, workflow management, and process improvements while collaborating with executive leadership...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.