Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$115K - $149K *
Drive strategic payer partnerships and enhance revenue cycle performance through oversight, mentorship, and data analysis. Collaborate across teams to resolve complex issues and improve operational ef...
Reposted 5 days ago
$237K - $296K *
Join a team that's driving innovation in oncology by leading clinical development and medical affairs. Collaborate across functions to advance pivotal programs and ensure operational excellence in a f...
2 weeks ago
$170K - $200K *
Empower a high-growth organization by leading operations strategy, enhancing client satisfaction, and driving efficiency through AI and automation. Collaborate with senior leadership to ensure financi...
2 days ago
Core Enterprise Account Executive TOLA
$222K - $278K *
Drive impactful change by consolidating technologies and digitizing workflows for enterprise customers, while fostering executive relationships and managing complex sales processes that promote safety...
Reposted 4 weeks ago
$110K - $130K *
Optimize deal structuring and commercial solutions, partnering with sales to drive strategic opportunities. Manage proposals, objection handling, and internal approvals while enhancing collaboration a...
3 weeks ago
$160K - $190K *
Empower nonprofit organizations to maximize their impact by leading product strategy and execution for innovative fundraising solutions. Drive growth through deep customer insights, collaborative part...
Reposted 2 weeks ago
Healthcare Coding Expert (certified professional coder)
$77K - $105K *
Join a dynamic team to analyze healthcare claims data, identify fraud trends, and support the Healthcare Fraud Prevention Partnership. Leverage your expertise to drive strategic outcomes and enhance c...
2 weeks ago
Enterprise Sales, Political & Advocacy Practice
$140K - $160K *
Empower growth by driving new revenue for political strategy and advocacy, shaping customer engagement, and developing impactful relationships with top-tier clients while leading a high-performing bus...
Reposted 1 week ago
$95K - $115K *
Contribute to impactful SaaS implementations, guiding clients through setup, data migration, and training while leading complex projects to success across municipal government sectors...
1 month ago
$120K - $140K *
Drive project success by leading cross-functional teams and managing multiple initiatives from inception to completion, ensuring alignment with client goals and quality standards while fostering stron...
Today
Conflicts Analyst II - Intake Compliance
$61K - $108K *
Play a key role in assessing and managing ethical business conflicts, supporting attorneys and firm practices by ensuring compliance with policies, while conducting in-depth research and analysis on n...
Reposted 2 weeks ago
$74K - $85K *
Lead the planning and execution of diverse research projects, ensuring alignment with organizational goals. Collaborate with stakeholders to manage timelines, deliverables, and budgets while fostering...
2 weeks ago
$93K - $116K *
Empower integrated marketing campaigns with a focus on account-based marketing. Collaborate with Sales to prioritize accounts, align messaging, and drive pipeline growth while managing multi-channel c...
3 days ago
Senior Medical Science Liaison, Neuroscience - New England Region
$151K - $237K *
Partner with us to advance medical strategy as a Medical Science Liaison, engaging with KOLs and HCPs, interpreting scientific data, and fostering expert networks to improve patient outcomes in a dyna...
2 weeks ago
Head of Customer Success, Payer & Employer
$137K - $205K *
Transform customer relationships by leading a team to enhance account management, drive product adoption, and ensure client success in the healthcare sector, fostering growth and retention across dive...
3 weeks ago
$115K - $150K *
Innovate your career with a strategic role focused on omnichannel marketing. Lead data-driven insights and creative recommendations for a top financial services brand, collaborating across teams to en...
3 weeks ago
Enterprise Customer Success Manager
$110K - $130K *
Unlock potential by overseeing a portfolio of enterprise accounts, fostering strategic partnerships, and driving user engagement to achieve measurable outcomes. Collaborate with internal teams to deli...
3 days ago
$70K - $99K *
Empower patient care by utilizing the nursing process to deliver individualized support. Collaborate with a dedicated team in a fast-paced environment, ensuring excellence in all phases of care from a...
Reposted yesterday
Commercial Lines Sr. Casualty Consultant
$135K - $180K *
Transform complex insurance challenges into tailored solutions while leading a dynamic analytics team, driving policy enhancements, and optimizing risk management strategies for a diverse client base...
Reposted 3 weeks ago
$107K - $188K *
Unlock potential by managing high-profile accounts and driving sales growth through strategic planning and complex negotiations. Leverage your expertise to develop tailored solutions and exceed revenu...
2 weeks ago
Coding & Reimbursement Auditor
$64K - $96K *
Transform health information management by auditing coding practices, providing expert consultation, and delivering educational workshops to enhance compliance and efficiency across various healthcare...
2 weeks ago
Senior Regional Marketer -- West Region
$200K - $245K *
Empower the oncology portfolio strategy by driving regional marketing initiatives, fostering KOL relationships, and executing launch tactics to optimize product adoption and customer engagement across...
6 days ago
Principal AI Transformation Consultant
$136K - $160K *
Drive transformation by partnering with architecture and engineering firms to enhance workflows through AI-enabled solutions. Collaborate with stakeholders to redefine processes, ensuring operational...
2 days ago
Government Contract Specialist - Risk Mitigation
$108K - $181K *
Transform contract management by leading risk mitigation strategies and ensuring compliance across government and commercial projects. Drive operational excellence and enhance proposal quality while m...
3 weeks ago
Director, Customer Success Management
$135K - $160K *
Lead the charge in scaling our Customer Success Management team, driving product adoption and retention across diverse customer segments. Collaborate cross-functionally to create impactful processes a...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.