Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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Oncologist Jobs in South Dakota

Sort By: Relevance

$120K - $150K *

Drive global access strategies for an innovative rare disease treatment, collaborating across teams to enhance payer insights and develop impactful materials. Lead initiatives that shape market entry...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$197K - $246K *

Lead the charge in building strategic relationships with national payers, ensuring access and reimbursement for products. Drive initiatives that enhance patient affordability while collaborating with...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Shape the future of healthcare by leading regional sales efforts, driving product launch success, and building high-performing teams. Collaborate cross-functionally to achieve sales goals and foster s...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $250K *

Transform clinical trials by ensuring patient safety and scientific integrity. Collaborate with stakeholders to uphold regulatory standards and optimize study protocols, while providing expert medical...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$135K - $165K *

Elevate your career by driving strategic acquisitions and value creation in a dynamic environment. Collaborate with cross-functional teams to identify targets, lead transactions, and build frameworks...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

$156K - $247K *

Lead the charge in patient engagement strategy, optimizing support programs and enhancing the patient journey from consideration to conversion. Collaborate across teams to amplify patient voices and d...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$143K - $194K *

Join a team that drives the execution of integrated media plans, ensuring compliance and operational excellence. Collaborate with cross-functional teams while enhancing brand strategies in healthcare...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$162K - $243K *

Lead a dynamic team in managing complex clinical research trials, ensuring project execution aligns with strategic objectives. Drive process improvements and maintain client relationships while overse...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$162K - $243K *

Lead a dynamic team in managing complex clinical research trials, ensuring strategic execution and client satisfaction. Drive project success through effective communication, budget oversight, and qua...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$90K - $110K *

Transform patient care by guiding Oncology patients through complex treatment plans, ensuring a smooth experience and providing essential medical services. Collaborate with healthcare teams to deliver...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Accelerate commercial growth by defining strategies for product families, collaborating across teams to translate market insights into actionable plans that drive revenue, profitability, and customer...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Healthcare

$110K - $130K *

Join a team that's dedicated to advancing hematology care by educating healthcare providers and driving demand for innovative therapies. Leverage your expertise to foster relationships and ensure a po...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$76K - $90K *

Join a team that's enhancing healthcare through expert support of EHR systems. Lead optimization initiatives, mentor junior analysts, and collaborate with diverse teams to improve clinical and operati...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$176K - $294K *

Shape the future of oncology care by building strategic partnerships with key accounts, driving quality initiatives, and collaborating with cross-functional teams to enhance patient outcomes and align...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$189K - $256K *

Join a global team to shape regulatory strategies in biotechnology, supporting product development and lifecycle management in Inflammation and Rare Diseases. Lead regulatory efforts, ensure complianc...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$221K - $335K *

Elevate clinical research by leading innovative studies, ensuring data integrity and patient safety. Collaborate cross-functionally to drive strategic initiatives and enhance clinical development whil...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$225K - $281K *

Join a team that's pushing the boundaries of oncology research! This key role involves designing and leading clinical trials, ensuring data integrity, and collaborating with global experts to advance...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$225K - $281K *

Explore your career in clinical development as you design and lead innovative oncology studies, ensuring data integrity and compliance while collaborating with cross-functional teams and cultivating r...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$136K - $187K *

Join a team that's dedicated to empowering patients with generalized Myasthenia Gravis through education and support. As a key point of contact, you'll coordinate care, provide resources, and ensure c...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $160K *

Drive WellTheory's growth in benefits consulting by cultivating strong partnerships, educating consultants, and supporting client strategies. This hands-on, individual contributor role requires strate...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$78K - $104K *

Inspire efficient EHR system performance by leading applications analysis and optimization. Drive project management and collaboration while mentoring team members and enhancing patient care through e...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $150K *

Join a team that's dedicated to enhancing clinical support through technical expertise and customer training. Drive product demonstrations and ensure customer satisfaction while collaborating with sal...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$90K - $115K *

Champion clinical excellence by leading and mentoring a dynamic ECM team, ensuring comprehensive patient care and adherence to individualized plans, while collaborating effectively with multidisciplin...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Join a dynamic strategy team to analyze oncology and specialty care initiatives, building models and providing insights that guide leadership decisions across various commercial segments...

RemoteRemote

Reposted 1 month ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$131K - $177K *

Drive innovative influencer strategies that amplify engagement and shape external narratives, collaborating across departments to elevate corporate reputation and patient storytelling in a highly dyna...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.