Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Oncologist Jobs in South Dakota

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$113K - $188K *

Shape the future of healthcare reimbursement by developing and implementing payment policies that enhance accuracy, compliance, and provider experience in a dynamic payer environment. Collaborate with...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$100K - $120K *

Champion new business opportunities in the diagnostic sales sector, driving growth in non-acute care markets. Achieve sales quotas, foster client relationships, and implement innovative technologies t...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$160K - $192K *

Accelerate progress at driving commercial performance by engaging healthcare providers, building relationships, and supporting product launches to ensure patient access to innovative therapies across...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $140K *

Optimize client relationships by ensuring seamless communication and operational excellence. Collaborate across teams to drive client success, manage deliverables, and enhance platform utilization whi...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$82K - $132K *

Unlock potential in revenue cycle management by leading innovative solutions, optimizing processes, and collaborating across departments to enhance operational efficiency and maximize revenue impact...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$90K - $110K *

Transform workplace health by leading multiple occupational health clinics. Drive operational excellence, foster client relationships, and enhance team performance while ensuring exceptional patient c...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Empower legal firms by leading the development of innovative IT solutions, driving market strategies, and enhancing service offerings. Collaborate with cross-functional teams to establish credibility...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Transform healthcare delivery by leading operations for a growing telehealth practice. Collaborate with clinical teams to enhance patient care through innovative solutions and efficient workflows, ens...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $215K *

Lead the charge in driving enterprise sales for strategic consulting accounts, coaching a team of Account Executives while managing complex sales cycles. Build executive relationships and execute grow...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$115K - $130K *

Drive rapid service restoration by leading IT incident management processes, ensuring effective communication and coordination for critical incidents. Leverage expertise in troubleshooting and support...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$100K - $185K *

Transform complex workflows by leading AI-driven change initiatives, guiding senior leaders through redesign and adoption processes, and ensuring measurable outcomes in legal, tax, and trade sectors...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Media

$120K - $165K *

Lead transformative consulting engagements to enhance healthcare coding and middle revenue cycle processes, driving operational efficiency, compliance, and financial performance across diverse project...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Business Services

$225K - $281K *

Lead detection and response strategy, building systems and automations to enhance security. Collaborate with teams to set standards, mentor engineers, and manage complex incidents, ensuring effective...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$106K - $167K *

Shape the future of physician relations by leading a dynamic team focused on enhancing patient acquisition and optimizing outreach strategies through data-driven insights and performance metrics...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$130K - $145K *

Champion client success by managing strategic partnerships with mid-sized enterprises. Drive measurable outcomes through relationship management, consultative problem-solving, and cross-functional col...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$75K - $100K *

Innovate user experiences by managing and enhancing the Salesforce platform. Collaborate with stakeholders to translate business needs into effective solutions, ensuring data quality and user adoption...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Technical Services

$135K - $160K *

Empower strategic growth by developing and executing multi-year partner strategies. Collaborate with sales and executive teams to enhance alliances, drive revenue, and foster innovation across North A...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$160K - $192K *

Drive commercial performance by engaging healthcare providers and executing territory plans. Collaborate with cross-functional teams to support product launches and ensure patient access to innovative...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Engineer advanced protein design models and collaborate with experts to innovate in AI Drug Discovery, driving the development of candidate antibody therapeutics through deep learning and systems biol...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $175K *

Accelerate patient care by optimizing therapy pathways and engaging key stakeholders. Collaborate with healthcare teams to enhance VTE awareness and program development, driving clinical initiatives a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$115K - $158K *

Shape the future of healthcare by leading the Organic Risk Adjustment program. Drive strategic initiatives, foster collaboration across teams, and implement innovative solutions to enhance performance...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $180K *

Empower commercial operations by leading a dynamic Deal Desk team, driving strategy, optimizing processes, and executing complex transactions in a fast-paced SaaS environment. Collaborate cross-functi...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $150K *

Drive enterprise growth by strategically engaging high-value accounts, orchestrating complex sales processes, and leveraging AI capabilities to enhance compliance workflows. Build executive relationsh...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $120K *

Join a team that's dedicated to providing exceptional anesthetic care in a Level II Trauma Center. Engage in diverse procedures and enjoy a supportive work environment with opportunities for professio...

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$100K - $120K *

Unlock potential by joining a dynamic anesthesia team at a Level II Trauma Center, where you'll practice diverse techniques and collaborate closely with anesthesiologists to ensure safe, effective pat...

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.