Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Pathology Coder III - Remote - 140825
$78K - $103K *
Champion accurate coding by interpreting diagnoses and resolving claim errors in this remote role. Leverage your expertise to ensure compliance with CPT, ICD-10, and HCPCS standards while collaboratin...
Reposted yesterday
Sr. Product Manager - Patient Recruitment
$110K - $130K *
Unlock potential by leading product strategy for patient recruitment, enhancing engagement and operational efficiency. Collaborate with cross-functional teams to drive measurable outcomes and improve...
1 week ago
Managed Care Contracting and Performance Advisor
$113K - $188K *
Shape the future of managed care by leading contract negotiations, performance monitoring, and strategic initiatives to optimize reimbursement and enhance payer relationships across healthcare service...
3 days ago
Oracle Application Systems Analyst (Mid-Level)
$83K - $112K *
Transform your career by leveraging your analytical skills to enhance application systems. Collaborate with teams to improve workflows, execute tests, and support mission-driven initiatives that stren...
1 week ago
Account Executive, Enterprise Suite - Corporate
$124K - $171K *
Champion the future of enterprise sales by driving top-down solutions into global enterprises. Leverage AI and LLM technologies to enhance client insights and foster relationships across all organizat...
2 days ago
Manager - EHR Application Training
$80K - $95K *
Shape the future of EHR training by leading a dedicated team to enhance application education, ensuring effective user adoption and operational readiness through strategic curriculum development and t...
Yesterday
Solutions Architect, Digital Platforms
$188K - $282K *
Drive the architecture for customer data integration across digital platforms, ensuring secure ingestion and transformation. Collaborate with cross-functional teams to create scalable solutions that e...
Yesterday
Senior/Staff AI Scientist, Antibody Design
$150K - $180K *
Transform innovative protein design through advanced AI techniques, enhancing antibody drug discovery. Collaborate across disciplines to maximize efficiency and impact, while leading research that set...
Reposted 4 weeks ago
Senior Legal Analyst & Litigation Project Manager
$92K - $124K *
Partner with us to enhance legal operations and implement eDiscovery processes. You'll lead customer data privacy initiatives, improving cross-functional collaboration and response strategies for comp...
Reposted 4 weeks ago
Solutions Architect, Enterprise
$224K - $326K *
Serve as a technical leader for large customers, guiding AI cloud strategies. Connect business priorities with scalable architecture while managing executive engagements and navigating complex decisio...
Reposted 1 week ago
Care Manager, Telephonic Nurse
$71K - $97K *
Transform patient care by guiding transitions and ensuring optimal service continuity. Leverage your nursing expertise to navigate healthcare options and advocate for patients in need of post-acute se...
Yesterday
Senior Director, Biostatistics
$295K - $314K *
Drive strategic biostatistical leadership for clinical development programs, overseeing statistical activities, collaborating with cross-functional teams, and ensuring high-quality data analysis to su...
3 weeks ago
Account Specialist (Altoona, PA)
$160K - $192K *
Transform commercial performance by engaging healthcare providers, driving product adoption, and collaborating with cross-functional teams to ensure patient access to innovative therapies across a def...
1 week ago
Regional Medical Science Director (South)
$200K - $235K *
Unlock potential by driving scientific excellence as a strategic partner, educating healthcare professionals on Immuno-Oncology and fostering relationships that support cancer therapeutic initiatives...
Reposted 1 week ago
Senior Director, Product Management, Agentic Platform
$192K - $303K *
Empower innovation as you lead the strategy and development of core platform primitives, driving the future of agentic systems and ensuring product teams can rapidly create and deploy advanced agents...
2 weeks ago
Lead Consultant CDH Implementation
$105K - $149K *
Transform complex Consumer-Directed Health implementations for major employers. Lead strategy, execution, and client engagement while serving as a subject-matter expert to ensure operational excellenc...
3 days ago
$110K - $130K *
Unlock potential by driving client success for enterprise accounts. Lead customer engagement, ensure adoption of solutions, and collaborate effectively with teams to promote renewals, expansion, and s...
Reposted 3 weeks ago
$145K - $191K *
Lead the charge in designing scalable cloud solutions that meet diverse healthcare needs, ensuring alignment with enterprise architecture and driving technology initiatives across multiple platforms t...
Reposted 1 month ago
$110K - $130K *
Advance client relationships and team performance as a strategic leader, overseeing captive insurance operations, driving excellence, and enhancing service delivery while managing complex engagements...
1 week ago
Senior Relationship Manager, Agribusiness
$128K - $268K *
Shape client relationships and business strategies in agribusiness. Engage with stakeholders to drive growth, manage credit quality, and deliver tailored financial solutions, ensuring performance targ...
Reposted 3 weeks ago
Senior Product and Design Strategist
$192K - $240K *
Unlock your potential as a Product + Design Strategist, leading ambiguous projects from concept to execution. Collaborate with cross-functional teams to create innovative, user-centered experiences an...
Reposted 4 weeks ago
Director, Telehealth Sales & Strategic Partnerships
$130K - $160K *
Accelerate growth in telehealth by leading strategic partnerships and business development. Drive revenue through innovative solutions, executive relationships, and a deep understanding of the healthc...
1 week ago
Director, Telehealth Sales & Strategic Partnerships
$135K - $160K *
Join a dynamic team to drive telehealth sales and strategic partnerships, identifying opportunities and building relationships across the healthcare ecosystem. Own the commercial process from prospect...
2 weeks ago
$77K - $85K *
Join a dedicated team to enhance clients' independence and quality of life through tailored occupational therapy interventions. Collaborate in a supportive environment, focusing on daily living skills...
1 week ago
Senior Staff Forward Deployed Engineer
$152K - $205K *
Lead the charge in architecting AI-driven solutions for enterprise clients, transforming complex data governance challenges into actionable insights. Collaborate with stakeholders to shape product evo...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.