Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$130K - $150K *
Join a team that's shaping high-impact strategies and narratives for enterprise growth. Collaborate with senior leaders to craft compelling pitches and support organic initiatives, driving success acr...
Reposted 2 weeks ago
Principle Div Consultant- Medicare Provider Network Strategy - Remote
$92K - $167K *
Drive strategic initiatives in Medicare Advantage provider networks, analyzing data and collaborating with leadership to enhance performance and achieve goals. Lead complex projects from inception to...
3 weeks ago
Clinical Care Leader - Aberdeen Medical Center - Med/Surg - Full Time
$76K - $114K *
Join a team that's dedicated to providing exceptional patient care while collaborating with healthcare professionals. Utilize your nursing expertise to lead and coordinate care in a dynamic medical/su...
2 days ago
$128K - $160K *
Lead the charge in delivering innovative AI and automation solutions, translating complex business needs into technical designs. Collaborate across teams to enhance productivity and drive continuous i...
3 days ago
Client Success Manager - Law Firms
$85K - $95K *
Lead the charge in client engagement and lifecycle management, driving retention and organic growth within legal accounts. Build relationships, identify cross-sell opportunities, and ensure high clien...
2 weeks ago
$110K - $130K *
Elevate market presence by driving adoption of innovative cardiac imaging solutions. Collaborate with healthcare professionals to enhance patient care, achieve sales targets, and optimize business str...
3 weeks ago
$110K - $130K *
Accelerate the deployment of innovative manufacturing processes for oncology products, ensuring compliance and collaboration across teams. Lead technology transfers and facility readiness to enhance p...
Reposted 1 week ago
Senior Intelligence Analyst - Russia & Eurasia Regional Focus
$120K - $145K *
Explore the complexities of Russian and Eurasian crypto threats, owning end-to-end attribution and analysis. Collaborate with a global team to produce actionable intelligence and represent expertise i...
Reposted yesterday
Director of Business Process Excellence
$155K - $205K *
Champion process excellence by optimizing workflows and driving cross-functional improvements. Collaborate with teams to enhance operational efficiency, reduce costs, and elevate service quality throu...
3 weeks ago
Nurse Practitioner/Physician Assistant - Cardiology
$90K - $110K *
Elevate cardiovascular care by collaborating with healthcare teams to provide comprehensive assessments, treatment plans, and follow-up for patients in both outpatient and inpatient settings, ensuring...
4 weeks ago
Director, Global Trade Compliance
$190K - $220K *
Drive your career by leading a global trade compliance program, ensuring adherence to international regulations while enhancing governance and operational efficiency across a complex business landscap...
3 weeks ago
Director of Operations, ES, North Carolina
$143K - $196K *
Elevate healthcare delivery by leading strategic partnerships and enhancing operational performance. Collaborate across teams to drive exceptional customer engagement and ensure alignment with clinica...
2 weeks ago
$135K - $180K *
Unlock potential by managing key relationships with insurance partners, overseeing operations, and ensuring compliance in a dynamic, team-focused environment. Thrive in a collaborative setting that dr...
1 month ago
Associate Director - Clinical Operations - Healthcare
$155K - $259K *
Transform healthcare performance by leading integrated optimization programs that enhance clinical, operational, and financial outcomes for hospitals and health systems. Drive measurable results throu...
3 days ago
Director Partnerships and Alliances
$199K - $370K *
Build strategic partnerships that drive growth and market success. Oversee the full lifecycle of partnerships, from sourcing and negotiation to execution and performance monitoring, ensuring alignment...
3 weeks ago
$120K - $150K *
Accelerate progress at the forefront of newborn health by leading strategic initiatives, managing multi-country programs, and driving impactful interventions to reduce neonatal mortality and stillbirt...
1 week ago
$160K - $220K *
Transform commercial contracting by leading negotiations and enhancing workflows. Collaborate with cross-functional teams to drive compliance and strategic outcomes, ensuring legal support scales effe...
3 weeks ago
$69K - $101K *
Lead the charge in holistic clinical care management, enhancing health outcomes through comprehensive assessments, care planning, and coordination for diverse member populations with complex needs...
2 weeks ago
$95K - $206K *
Join a dynamic team as a Clinician Player Coach, mentoring peers while delivering high-quality in-home evaluations. Balance clinical duties with mentorship, ensuring exceptional care and support for n...
4 weeks ago
Sr. Account Executive, Enterprise
$112K - $150K *
Unlock potential by driving enterprise sales to Fortune 500 clients, managing end-to-end sales cycles, and fostering strategic relationships with C-level executives to deliver impactful SaaS complianc...
1 week ago
$100K - $150K *
Build strategic partnerships and drive revenue growth by managing high-potential accounts. Collaborate with internal teams to enhance partner engagement and achieve production targets while fostering...
4 weeks ago
NeuroPsych Account Specialist - Baton Rouge, LA
$123K - $168K *
Engage with healthcare professionals to drive product growth and acceptance. Build lasting relationships, educate stakeholders, and collaborate cross-functionally to enhance market presence and uphold...
2 days ago
Director, Acquisitions & Transactions
$150K - $180K *
Lead multifamily transactions from sourcing to closing, ensuring disciplined execution and strategic alignment across teams. Drive outcomes through strong negotiation, relationship management, and a r...
6 days ago
Senior Coding Compliance Auditor - Outpatient
$76K - $131K *
Join a team that's redefining healthcare compliance by leading detailed coding audits, mentoring auditors, and driving innovative solutions to enhance compliance and operational excellence in a dynami...
3 weeks ago
Pathology Coder III - Remote - 140825
$78K - $103K *
Champion accurate coding by interpreting diagnoses and resolving claim errors in this remote role. Leverage your expertise to ensure compliance with CPT, ICD-10, and HCPCS standards while collaboratin...
Reposted yesterday
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.