Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Oncologist Jobs in South Dakota

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$175K - $222K *

Engage in architecting high-volume autonomous agent pipelines, ensuring safety, performance, and compliance. Own the generator-verifier architecture and CI/CD processes while setting engineering stand...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$140K - $180K *

Empower teams by leading the technical vision and delivery standards for ServiceNow. Drive high-quality implementations across engagements while mentoring talent and collaborating with management to e...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Business Services

$147K - $217K *

Lead transformative analytics initiatives in life sciences, driving innovation and client success. Mentor teams, enhance measurement standards, and collaborate cross-functionally to deliver actionable...

RemoteRemote

3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$102K - $164K *

Join a team that's shaping the future of enterprise solutions by leading innovative design and implementation of scalable architectures. Collaborate with stakeholders, define strategy, and ensure adhe...

RemoteRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$111K - $159K *

Lead clinical operations in review of medical certifications for leave requests. Build and manage a dedicated team, standardize workflows, and ensure compliance while driving continuous improvements i...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$90K - $105K *

Lead the charge in enhancing quality assurance and performance oversight by analyzing requirements and deliverables, ensuring alignment with contractual standards, and driving process improvements for...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$69K - $104K *

Unlock your potential as a coding auditor, ensuring accurate documentation and coding while promoting compliance and reimbursement optimization. Collaborate with coders and specialists to enhance proc...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$172K - $203K *

Elevate women's health outcomes by developing advanced machine learning models. Lead projects, mentor junior team members, and collaborate with cross-functional teams to drive innovation and commercia...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Consumer Technology

$80K - $93K *

Grow your career with a dynamic Finance team as a Staff Accountant, supporting financial operations for R&D programs and USG contracts. Collaborate across departments to ensure accurate financial reco...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $200K *

Lead the charge in optimizing clinical documentation processes, enhancing provider education, and fostering collaboration with service line leaders to improve documentation integrity and reduce admini...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$97K - $145K *

Join a team that's dedicated to ensuring accurate coding and compliance for clinical services, leveraging your expertise to enhance revenue cycle management and contribute to optimal healthcare outcom...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$160K - $180K *

Reimagine customer success by driving onboarding, adoption, and renewals for a diverse portfolio. Collaborate with cross-functional teams to ensure every user thrives, turning initial deployments into...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$145K - $195K *

Engage with patients and healthcare providers to streamline access to therapy. Collaborate with internal teams and specialty pharmacies to resolve reimbursement issues and enhance patient support. Dri...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$93K - $109K *

Innovate alongside executives by providing strategic support to drive organizational success, manage high-stakes priorities, and enhance workflow efficiency. You'll serve as a vital liaison and truste...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$130K - $160K *

Partner with us to showcase cutting-edge workforce management solutions, leveraging your pre-sales expertise and presentation skills to drive value for prospective clients in a dynamic, fast-paced env...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$190K - $225K *

Drive scientific engagement as a Senior Medical Science Liaison, fostering relationships with Key Opinion Leaders and healthcare professionals. Leverage your expertise in cardiovascular disease to sup...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Join a team that's shaping the future of Quality Control laboratories by providing technical oversight for startup, validation, and compliance across multiple manufacturing sites, ensuring operational...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$90K - $103K *

Develop and optimize health and welfare plans, ensuring compliance and efficient administration. Collaborate with TPAs, oversee claims performance, and enhance employee engagement through effective co...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Champion seamless communication by managing VoIP and telephony systems, ensuring optimal performance and user satisfaction. Collaborate across departments to analyze data, enhance workflows, and uphol...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$156K - $212K *

Shape the future of training by leading impactful learning solutions for obesity and related conditions. Collaborate with cross-functional teams to design and deliver engaging curricula that enhance f...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$145K - $218K *

Architect innovative market access strategies to enhance U.S. reimbursement for cutting-edge healthcare solutions. Collaborate across functions to drive payer engagement, coding, and coverage initiati...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$119K - $186K *

Advance your career by providing strategic legal counsel on data governance, privacy, and cybersecurity within a dynamic healthcare environment. Collaborate with cross-functional teams to drive compli...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$160K - $190K *

Join a team that's driving excellence in clinical operations, leading global studies and ensuring regulatory compliance. Utilize your project management expertise to enhance efficiency and maintain hi...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Engage as a claims advocate, collaborating with Risk Advisors to resolve workers' compensation claims. Build trusted relationships and provide expert guidance to clients, ensuring prompt and fair hand...

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$99K - $136K *

Elevate your career by driving strategic growth in Hemostasis solutions. As a key player, you'll lead complex sales cycles, cultivate executive relationships, and deliver measurable value across healt...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.