Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Principal Software Architect - Emerging Technologies
$175K - $222K *
Engage in architecting high-volume autonomous agent pipelines, ensuring safety, performance, and compliance. Own the generator-verifier architecture and CI/CD processes while setting engineering stand...
Today
Director, ServiceNow Architect & Technical Delivery
$140K - $180K *
Empower teams by leading the technical vision and delivery standards for ServiceNow. Drive high-quality implementations across engagements while mentoring talent and collaborating with management to e...
Reposted 3 weeks ago
$147K - $217K *
Lead transformative analytics initiatives in life sciences, driving innovation and client success. Mentor teams, enhance measurement standards, and collaborate cross-functionally to deliver actionable...
3 weeks ago
Senior Enterprise Solution Architect
$102K - $164K *
Join a team that's shaping the future of enterprise solutions by leading innovative design and implementation of scalable architectures. Collaborate with stakeholders, define strategy, and ensure adhe...
Reposted 4 weeks ago
$111K - $159K *
Lead clinical operations in review of medical certifications for leave requests. Build and manage a dedicated team, standardize workflows, and ensure compliance while driving continuous improvements i...
Reposted 1 week ago
Remote Mid-Level PMO Quality Analyst (VA ESOM)
$90K - $105K *
Lead the charge in enhancing quality assurance and performance oversight by analyzing requirements and deliverables, ensuring alignment with contractual standards, and driving process improvements for...
Yesterday
$69K - $104K *
Unlock your potential as a coding auditor, ensuring accurate documentation and coding while promoting compliance and reimbursement optimization. Collaborate with coders and specialists to enhance proc...
1 month ago
Senior ML Data Scientist - Women's Health
$172K - $203K *
Elevate women's health outcomes by developing advanced machine learning models. Lead projects, mentor junior team members, and collaborate with cross-functional teams to drive innovation and commercia...
1 week ago
Staff Accountant, USG Contracts
$80K - $93K *
Grow your career with a dynamic Finance team as a Staff Accountant, supporting financial operations for R&D programs and USG contracts. Collaborate across departments to ensure accurate financial reco...
Reposted 6 days ago
Clinical Documentation Integrity Lead - Service Line (Remote)
$150K - $200K *
Lead the charge in optimizing clinical documentation processes, enhancing provider education, and fostering collaboration with service line leaders to improve documentation integrity and reduce admini...
Today
Director, Client Coding Integration
$97K - $145K *
Join a team that's dedicated to ensuring accurate coding and compliance for clinical services, leveraging your expertise to enhance revenue cycle management and contribute to optimal healthcare outcom...
Reposted 1 week ago
$160K - $180K *
Reimagine customer success by driving onboarding, adoption, and renewals for a diverse portfolio. Collaborate with cross-functional teams to ensure every user thrives, turning initial deployments into...
4 days ago
Associate Director, Patient Services and Distribution Case Management - Great Lakes/Northeast Region
$145K - $195K *
Engage with patients and healthcare providers to streamline access to therapy. Collaborate with internal teams and specialty pharmacies to resolve reimbursement issues and enhance patient support. Dri...
2 weeks ago
Executive Assistant - Bellevue
$93K - $109K *
Innovate alongside executives by providing strategic support to drive organizational success, manage high-stakes priorities, and enhance workflow efficiency. You'll serve as a vital liaison and truste...
Reposted 1 week ago
$130K - $160K *
Partner with us to showcase cutting-edge workforce management solutions, leveraging your pre-sales expertise and presentation skills to drive value for prospective clients in a dynamic, fast-paced env...
Yesterday
Senior Medical Science Liaisons (MSL) - Cardiovascular, Florida
$190K - $225K *
Drive scientific engagement as a Senior Medical Science Liaison, fostering relationships with Key Opinion Leaders and healthcare professionals. Leverage your expertise in cardiovascular disease to sup...
2 weeks ago
Quality Control, Validation Lead
$110K - $130K *
Join a team that's shaping the future of Quality Control laboratories by providing technical oversight for startup, validation, and compliance across multiple manufacturing sites, ensuring operational...
2 weeks ago
$90K - $103K *
Develop and optimize health and welfare plans, ensuring compliance and efficient administration. Collaborate with TPAs, oversee claims performance, and enhance employee engagement through effective co...
1 month ago
Unified Communications Analyst
$80K - $95K *
Champion seamless communication by managing VoIP and telephony systems, ensuring optimal performance and user satisfaction. Collaborate across departments to analyze data, enhance workflows, and uphol...
2 weeks ago
Senior Manager, Training & Development, Obesity & Related Conditions - U.S. Remote
$156K - $212K *
Shape the future of training by leading impactful learning solutions for obesity and related conditions. Collaborate with cross-functional teams to design and deliver engaging curricula that enhance f...
Yesterday
Manager, Market Access & Reimbursement
$145K - $218K *
Architect innovative market access strategies to enhance U.S. reimbursement for cutting-edge healthcare solutions. Collaborate across functions to drive payer engagement, coding, and coverage initiati...
2 weeks ago
Senior Counsel - Data Governance, Privacy and Cybersecurity
$119K - $186K *
Advance your career by providing strategic legal counsel on data governance, privacy, and cybersecurity within a dynamic healthcare environment. Collaborate with cross-functional teams to drive compli...
1 week ago
Senior Manager, Clinical Operations Programs
$160K - $190K *
Join a team that's driving excellence in clinical operations, leading global studies and ensuring regulatory compliance. Utilize your project management expertise to enhance efficiency and maintain hi...
Reposted 3 days ago
Workers Compensation Claims Administrator
$80K - $95K *
Engage as a claims advocate, collaborating with Risk Advisors to resolve workers' compensation claims. Build trusted relationships and provide expert guidance to clients, ensuring prompt and fair hand...
1 week ago
Hemostasis Sales Specialist - Northern California Region
$99K - $136K *
Elevate your career by driving strategic growth in Hemostasis solutions. As a key player, you'll lead complex sales cycles, cultivate executive relationships, and deliver measurable value across healt...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.