Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$145K - $160K *
Pioneer data-driven insights by collaborating with cross-functional teams to enhance business strategies. Leverage advanced analytics and visualization skills to drive operational improvements and sup...
2 weeks ago
$190K - $225K *
Elevate your career by joining a dynamic Conflicts Team, where you'll analyze complex conflict reports, advise on risk management, and enhance ethical practices in a fully remote environment, ensuring...
1 week ago
Regulatory Policy and Intelligence Associate Director
$155K - $210K *
Shape the future of regulatory policy by leading initiatives that influence key decisions and drive alignment across teams. Collaborate with stakeholders to advocate for impactful policies that suppor...
Today
$149K - $248K *
Drive your career with technical leadership in Palantir Foundry. Lead design, deployment, and enhancement projects for federal health initiatives, ensuring secure and scalable data architecture and op...
1 month ago
$100K - $120K *
Elevate your career by leading financial planning and analysis, managing budgets, and driving strategic insights. Collaborate with cross-functional teams to enhance operational performance and deliver...
3 weeks ago
Senior Support Solutions Specialist
$85K - $95K *
Join as a critical team member to manage and enhance productivity platforms, ensuring stability, security, and user satisfaction. Collaborate across teams to drive operational maturity and navigate co...
1 month ago
$150K - $180K *
Help us drive revenue growth by leading the full sales cycle in the Digital Science sector, engaging with C-suite leaders and aligning solutions with enterprise strategies to enhance decision-making a...
3 weeks ago
$110K - $130K *
Elevate your career by architecting scalable analytics systems and AI-driven workflows that empower decision-making across our enterprise SaaS business, paving the way for innovation and growth in a d...
Reposted yesterday
Senior Copywriter, Promotional Medical Writing
$80K - $100K *
Shape the future of medical communications by crafting high-quality, scientifically accurate content. Collaborate with diverse teams to deliver impactful resources that meet client needs while mentori...
2 days ago
National Field Development Specialist - Foot and Ankle & Trauma
$131K - $240K *
Shape the future of training and development in orthopedic medical devices, enhancing sales effectiveness and fostering strong partnerships across teams. Drive learning initiatives and support surgica...
Reposted 3 days ago
Clinical Informatics Integrator
$110K - $130K *
Lead the charge in managing informatics projects from planning to delivery, ensuring timely decision-making and risk management. Collaborate with cross-functional teams to enhance health information e...
4 weeks ago
Senior Clinical Research Associate
$108K - $201K *
Join a dynamic team to drive clinical trials, ensuring compliance and quality. Manage site relationships, monitor trial progress, and collaborate with cross-functional teams to deliver innovative ther...
Today
Account Specialist (Mayfield Heights, OH)
$160K - $192K *
Discover a pivotal role in driving commercial performance and patient access. Engage healthcare providers, build relationships, and support product launches while collaborating with cross-functional t...
1 week ago
Executive Director, Clinical Supply Consulting & Intelligence
$250K - $350K *
Lead the development of a clinical supply consulting practice, combining expertise in forecasting, planning, and optimization to enhance decision-making for sponsors. Drive innovation and commercial g...
2 weeks ago
Senior Business Development Director - RWD Licensing
$150K - $180K *
Drive your career with a strategic sales leadership role focused on enterprise growth in healthcare. Lead complex business development efforts, build executive relationships, and shape solutions that...
Yesterday
Sr Editor, Consent Form Development
$66K - $116K *
Elevate your career by joining a team that reviews and edits informed consent forms, ensuring compliance with regulatory standards while mentoring new editors and enhancing organizational knowledge in...
1 week ago
Senior Quality Operations Specialist, CAP & Monitoring
$74K - $98K *
Elevate quality operations by leading corrective action plans (CAPs) for regulatory compliance. Collaborate with cross-functional teams to drive accountability, resolve barriers, and ensure sustained...
3 weeks ago
$140K - $175K *
Drive operational excellence by leading strategic initiatives and managing a team to enhance Care Operations. Transform high-level strategies into scalable systems that improve care delivery and patie...
2 weeks ago
$100K - $160K *
Lead critical evaluations of biological risks, mentor junior specialists, and ensure high-quality labeling for AI safety classifiers in a dynamic life-sciences environment focused on biodefense and bi...
3 days ago
$88K - $154K *
Lead the charge in enhancing safety and quality standards; administer the Risk Program and conduct audits, assessments, and training. Collaborate with various stakeholders to ensure compliance and imp...
Reposted 3 weeks ago
Mid-Enterprise Account Executive, East Coast
$200K - $250K *
Empower growth in the cybersecurity sector by driving sales, acquiring new accounts, and fostering strong customer relationships. Leverage your expertise to introduce innovative solutions and exceed s...
1 week ago
Case Manager, Registered Nurse - Remote
$54K - $116K *
Champion transformative patient care by leading community-based case management initiatives. Collaborate with members, providers, and organizations to enhance health outcomes and support individuals t...
Today
Manager, Clinical Data Management Study Lead
$114K - $187K *
Optimize clinical data management processes by leading teams and ensuring compliance with standards. Collaborate with stakeholders to enhance data quality and streamline operations across multiple com...
2 days ago
Executive Director, AP World Languages and Arts Department Head, Curriculum & Assessment
$144K - $205K *
Lead the charge in enhancing AP World Languages and Arts by ensuring assessment quality, driving strategic growth, and managing a diverse team. Collaborate with leadership to influence enterprise deci...
1 week ago
$67K - $108K *
Transform patient care by performing echocardiography tests and procedures, ensuring adherence to industry standards. Collaborate with healthcare professionals while providing exceptional service in a...
6 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.