Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Global Marketing Director, Oncology
$195K - $265K *
Transform global marketing strategies in oncology by leading cross-functional teams, driving insights, and optimizing brand value for pipeline assets. Collaborate with stakeholders to enhance commerci...
Today
Senior Oncology Account Manager, Long Island
$150K - $230K *
Lead the charge in promoting innovative oncology solutions while building strong relationships with key stakeholders. Drive performance goals and enhance patient access through strategic engagement an...
1 week ago
Associate Medical Director, Renal Cancer Theranostics
$175K - $210K *
Champion the execution of a comprehensive medical affairs plan for renal cancer theranostics, driving cross-functional alignment and strategic initiatives to enhance patient outcomes and advance clini...
2 weeks ago
Associate Director - Medical Science Liaison, Oncology (GI/Thoracic Focus) - Upper Midwest
$156K - $250K *
Lead the charge in scientific dialogue with key healthcare professionals, providing critical insights and support within your therapeutic area. Utilize your expertise to enhance patient outcomes and f...
Reposted 2 days ago
Senior Oncology Account Manager, Phoenix West
$150K - $230K *
Engineer impactful relationships in oncology by promoting innovative therapies, driving patient access, and exceeding performance goals. Collaborate with stakeholders to enhance care delivery and leve...
1 week ago
Senior Oncology Account Manager, Louisville
$150K - $230K *
Elevate patient care by driving oncology product success through strategic relationships and innovative solutions. Collaborate with key stakeholders to ensure timely access to therapies while exceedin...
1 week ago
Senior Director, Early Oncology
$230K - $345K *
Transform clinical trial management by leading early-phase oncology programs. Drive strategic vision, operational excellence, and cross-functional collaboration to ensure timely, budget-compliant exec...
Yesterday
Senior Director, Reimbursement (Oncology)
$227K - $313K *
Elevate your career by leading strategic reimbursement initiatives, optimizing revenue cycles, and collaborating with key stakeholders to enhance patient access and billing processes in a dynamic heal...
2 weeks ago
$175K - $250K *
Join a team that's optimizing medical cost management and driving financial performance across Commercial lines. Leverage your expertise in healthcare economics to influence strategic contracting and...
1 week ago
Senior Clinical Scientist - Oncology - Home Based
$110K - $130K *
Transform your career with a pivotal role in clinical research, leading oncology studies and collaborating with cross-functional teams to ensure scientific excellence and regulatory compliance while m...
1 week ago
$195K - $277K *
Drive innovative clinical oncology studies by designing protocols, collaborating with teams, and ensuring compliance with regulations. Leverage expertise to analyze data, support publications, and mai...
3 weeks ago
Theranostics Specialist - Southeast
$110K - $130K *
Advance the adoption of cutting-edge prostate cancer imaging solutions while leading site activations, enhancing workflows, and ensuring optimal product utilization in the oncology sector, supporting...
Reposted 3 weeks ago
Clinical Informatics & Ontology Lead
$120K - $145K *
Lead the design and governance of clinical ontologies and terminology services, ensuring data quality and alignment with product needs. Collaborate cross-functionally to enhance data normalization and...
Today
Associate Director, Global Value & Access, Hematology
$153K - $203K *
Drive global access and pricing strategies for hematology assets, ensuring timely reimbursement and optimal patient access. Collaborate with cross-functional teams to develop evidence-based toolkits a...
3 weeks ago
Global Pharmacovigilance (PV) Scientist, Manager- Oncology
$116K - $157K *
Lead innovative safety strategies in pharmacovigilance, collaborating with cross-functional teams to ensure patient safety throughout the product lifecycle, from development to post-marketing, while m...
4 weeks ago
$100K - $120K *
Elevate your career by designing and optimizing EpicCare Ambulatory workflows. Collaborate with clinicians to enhance EHR functionality, troubleshoot issues, and ensure seamless operations across heal...
Today
Senior Director, Late Oncology
$230K - $345K *
Shape the future of late-stage oncology clinical trials by leading strategic initiatives, ensuring operational excellence, and fostering cross-functional partnerships to drive successful trial executi...
Today
$145K - $165K *
Drive impactful clinical research strategies by collaborating with cross-functional teams, analyzing data, and disseminating findings through publications and presentations. Elevate your career while...
Today
Associate Medical Director, Prostate Cancer Theranostics
$175K - $210K *
Drive the execution of a comprehensive medical affairs plan for prostate cancer theranostics, collaborating across functions to enhance strategy, launch readiness, and lifecycle planning while advanci...
2 weeks ago
Senior Oncology Account Specialist Prostate Cancer Columbus, OH
$108K - $250K *
Join a dynamic team to enhance patient care by promoting innovative oncology solutions, educating healthcare providers, and driving strategic account management to elevate brand presence and improve p...
3 days ago
Regional Director - Hematology - Ohio Valley
$212K - $287K *
Transform the Hematology landscape by leading a high-performing sales team, driving strategic initiatives, and ensuring compliance while exceeding sales objectives in the Great Plains region...
2 days ago
Senior Medical Director - Oncology
$254K - $382K *
Pioneer innovative clinical strategies as a senior medical leader, driving excellence in study execution and client engagement. Collaborate with cross-functional teams to enhance patient care and oper...
Yesterday
Senior Advisor, Clinical Pharmacology
$153K - $268K *
Join our team to provide expert clinical pharmacology insights, driving dose selection and study design for innovative therapies. Collaborate with cross-functional teams to translate complex data into...
1 week ago
$100K - $120K *
Elevate operational efficiency by managing account priorities and delivering proactive business solutions. Collaborate with teams to ensure high-quality service and maintain strong relationships with...
3 weeks ago
$72K - $90K *
Lead data-driven insights to enhance business performance, collaborating across teams to support strategic initiatives. Utilize technical skills in SQL, Python, and data visualization to drive impactf...
4 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.