Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Oncologist Jobs in South Dakota

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$150K - $190K *

Lead the charge in underwriting and managing complex enterprise accounts, driving profitable business through strategic broker partnerships while mentoring junior underwriters and shaping portfolio st...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$150K - $180K *

Grow enterprise SAP relationships by managing key accounts and driving new business. Leverage your expertise to expand client portfolios, develop strategic plans, and ensure client satisfaction while...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$117K - $161K *

Drive impactful clinical intelligence initiatives by analyzing AI opportunities, conducting feasibility studies, and collaborating with cross-functional teams to enhance patient care and operational e...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$140K - $170K *

Join a team that's dedicated to advancing tuberculosis (TB) prevention and care. As a senior technical advisor, you'll lead innovative strategies, collaborate with global partners, and enhance TB prog...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Education, Government & Non-Profit

$120K - $145K *

Lead quantitative user research across product lines, shaping strategy and answering critical questions with data-driven insights. Collaborate with teams to prioritize research that mitigates risk and...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $120K *

Transform the insurance appeals process by managing, researching, and drafting compliant responses to billing deductions. Collaborate with legal teams to enhance efficiency and build strong relationsh...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$74K - $99K *

Shape the future of regulatory submissions by ensuring high-quality QC reviews of clinical documents. Collaborate with global teams to meet project timelines while maintaining compliance with industry...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Join us to empower community coalitions in preventing youth substance use. As a Project Officer, you'll manage grants, provide technical assistance, and enhance local capacities, all while collaborati...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Drive sales strategy for Diagnostic Cardiology and Vital Signs Monitors in the Indiana, Ohio, and Kentucky territory. Collaborate with teams to enhance customer support and leverage market insights fo...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$110K - $166K *

Lead the charge in managing site contract negotiations and agreements, ensuring alignment with clinical study timelines. Collaborate with cross-functional teams to enhance contract processes and mento...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $178K *

Transform the patient engagement landscape in clinical trials by developing and delivering strategic support initiatives. Partner with diverse stakeholders to enhance participation and optimize patien...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Elevate the quality assurance landscape by building robust test automation frameworks, driving efficient testing practices, and partnering with cross-functional teams to ensure excellence in software...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$205K - $278K *

Empower strategic growth by shaping and executing initiatives that drive corporate development. Collaborate closely with C-suite executives, influence key decisions, and lead high-priority projects to...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Unlock potential by leading strategic account management initiatives, driving customer satisfaction and revenue growth through effective relationship building and expansion strategies in a dynamic ent...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $160K *

Contribute to malaria programming by providing technical leadership and support to country teams, ensuring quality interventions, compliance, and strategic resource investments across health facilitie...

RemoteRemote

6 days ago

  •   11 - 15 years exp.  •   Education, Government & Non-Profit

$170K - $205K *

Drive sales success by developing strategic account plans and fostering relationships with healthcare professionals. Collaborate cross-functionally to launch a new kidney transplant product and achiev...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$129K - $231K *

Elevate nonclinical toxicology operations by managing study execution, ensuring compliance, and fostering collaboration across teams to advance innovative therapies for sleep-wake disorders. Drive acc...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Unlock potential by leading innovative strategies for AI-enabled maternal care. Drive program implementation, manage complex projects, and engage stakeholders to enhance health outcomes in low- and mi...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$73K - $132K *

Drive organizational change by analyzing processes, engaging stakeholders, and implementing effective strategies. Collaborate with teams to enhance operational efficiency and ensure successful adoptio...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$114K - $165K *

Shape the future of compliance by leading governance initiatives, managing risk, and ensuring audit readiness. Collaborate across teams to enhance security and policy frameworks, driving effective com...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$262K - $284K *

Optimize pediatric drug development strategies as a clinical pharmacology leader, overseeing pharmacometric analyses and regulatory submissions, while translating complex data into actionable decision...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$125K - $168K *

Pioneer application modernization efforts by leading agile teams, driving technical outcomes, and enhancing developer experiences. Collaborate with clients to deliver measurable business results while...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$135K - $160K *

Elevate our deal desk function by transforming processes into a scalable model. You'll implement AI tools, streamline order forms, and ensure efficient deal structuring while collaborating with cross...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$67K - $100K *

Develop and deliver role-based training for EHR applications, ensuring curriculum accuracy and effectiveness. Collaborate with teams to optimize training environments and support user engagement in he...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Drive healthcare transformation by leading advanced consulting initiatives, enhancing delivery systems, and improving health outcomes. Collaborate with clients and stakeholders to implement strategic...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.