Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Manager, Clinical Conduct
$90K - $110K *
Empower cross-functional teams to drive the Future of Medicine initiatives, ensuring scalable processes and compliance while enhancing patient safety and experience through strategic planning and exec...
1 week ago
$205K - $240K *
Shape the future of oncology as a Senior Medical Science Liaison, creating impactful scientific engagement within hematology and oncology that enhances patient care. Collaborate with KOLs and cross-fu...
Reposted 1 week ago
Payer Strategy & Analytics Senior
$103K - $192K *
Shape the future of healthcare reimbursement by leading analytics for payor contracting and out-of-network strategies. Collaborate with cross-functional teams to optimize financial outcomes and drive...
2 days ago
$69K - $119K *
Transform the landscape of clinical documentation by educating and mentoring teams, ensuring compliance, and enhancing documentation accuracy to optimize patient care and coding outcomes...
Yesterday
Director, Managed Markets - Regional - Northeast
$235K - $270K *
Join a team that's driving access strategy across the Northeast, managing key payer relationships and ensuring launch readiness for rare disease therapies. Collaborate with cross-functional teams to o...
3 days ago
$110K *
Champion the clinical operations team, ensuring project success through resource management, process efficiencies, and compliance. Drive training, metrics development, and mentorship to enhance team c...
Reposted 3 days ago
$135K - $160K *
Help us shape the future of pulmonary care by leveraging your clinical expertise to drive product development, enhance workflows, and ensure effective solutions for COPD, asthma, and other pulmonary c...
2 weeks ago
Medical Review Analyst - Medicare
$66K - $106K *
Lead the charge in conducting medical record reviews and applying clinical judgment to ensure accurate claim payment decisions while supporting fraud investigations and compliance efforts...
3 weeks ago
Sr. Staff Applied AI Engineer (Tech Lead)
$150K - $180K *
Shape the future of AI by leading technical direction and architecture for innovative agent systems. Collaborate with cross-functional teams to ensure quality, security, and efficiency while mentoring...
4 weeks ago
Key Account Manager - Houston, TX
$170K - $205K *
Transform the U.S. sales landscape by driving strategic account plans and fostering relationships in the kidney transplant sector, ensuring optimal product utilization and achieving revenue targets th...
3 weeks ago
Customer Success Manager - New York Metro
$132K - $181K *
Join our team to manage and optimize customer service projects, ensuring timely and quality service delivery. Leverage your expertise to strengthen internal partnerships and drive a positive customer...
Reposted 4 days ago
Associate Director, Business Improvement
$130K - $160K *
Reimagine business improvement strategies as a senior contributor, leading high-impact initiatives across functions. Drive alignment, governance, and measurable outcomes while influencing stakeholders...
2 weeks ago
$110K - $130K *
Unlock potential by leading cross-functional initiatives to enhance caregiver enrollment technology. Drive strategy, optimize user experiences, and leverage data analytics to achieve growth in a dynam...
Yesterday
Sr. Sustainability Engineer - Radiopharmaceutical Manufacturing
$110K - $130K *
Innovate your career with a key role supporting the global launch and technical operations of radiopharmaceuticals, driving compliance, quality initiatives, and collaboration with CDMOs while leading...
Reposted 1 week ago
Clinical Documentation Integrity Supervisor
$110K - $159K *
Inspire excellence in clinical documentation by leading a team of specialists, ensuring quality assurance, and fostering professional development. Collaborate with stakeholders to enhance operational...
Reposted today
Clinical Documentation Integrity Supervisor
$110K - $159K *
Empower the Clinical Documentation Integrity team by ensuring staff competency through quality assurance, training, and performance management. Collaborate on action plans and foster associate develop...
2 days ago
Clinical Documentation Integrity Supervisor
$110K - $159K *
Lead the charge in enhancing clinical documentation integrity by supervising staff, conducting quality reviews, and fostering professional development. Collaborate with teams to implement effective st...
2 weeks ago
$80K - $135K *
Advance educational research by analyzing data and synthesizing findings to enhance student access to advanced courses. Collaborate with stakeholders to design studies, build dashboards, and communica...
1 week ago
Staff Technical Program Manager
$120K - $145K *
Drive execution of complex technical initiatives, translating business vision into actionable programs. Collaborate with cross-functional teams to ensure alignment with company objectives and measurab...
1 week ago
Senior Staff Frontend Engineer
$150K - $180K *
Join us to architect a unified web platform that enhances user experience across multiple services. Lead front-end development, optimize performance, and mentor engineers while ensuring seamless integ...
3 days ago
Senior Software Engineer, Portal Application
$125K - $157K *
Join our dynamic team to design and enhance a web portal application, improving user experience and functionality. Collaborate with engineers and product managers to deliver impactful solutions that s...
3 days ago
Regional Sales Director - Milwaukee
$180K - $215K *
Transform your career by leading regional sales efforts for a groundbreaking product. Drive performance, build a high-performing team, and engage with key healthcare providers in a fast-paced, entrepr...
1 week ago
$61K - $104K *
Engage in impactful public health data analysis, utilizing quantitative skills and epidemiological knowledge to enhance surveillance programs and support critical health initiatives...
Today
$140K - $165K *
Elevate your career by driving strategic pricing initiatives and financial analysis. Collaborate cross-functionally to develop business cases, optimize pricing models, and present actionable insights...
4 weeks ago
Senior Nuclear Criticality Safety Engineer
$135K - $175K *
Drive criticality safety evaluations and develop safety programs for innovative nuclear fuel recycling. Collaborate with a dynamic team to ensure compliance and enhance safety measures in a fast-paced...
4 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.