Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Executive Director, Account Management
$255K - $310K *
Lead a high-performing team to execute market access strategies, optimize payer engagement, and enhance product positioning. Drive collaboration across stakeholders to ensure effective reimbursement a...
1 week ago
Director of Risk Adjustment Regulatory Audits
$150K - $206K *
Drive strategic risk management initiatives by leading regulatory audits, enhancing operational processes, and fostering cross-functional collaboration to minimize financial impacts and improve audit...
2 weeks ago
$100K - $122K *
Take ownership of financial planning and analysis for G&A expenses, driving insights and reporting for senior leadership. Collaborate with teams to enhance budgeting, forecasting, and variance analysi...
1 week ago
$110K - $130K *
Innovate in cancer research by designing and deploying advanced AI and machine learning solutions. Collaborate with cross-functional teams to develop multimodal models integrating diverse clinical dat...
2 days ago
$150K - $180K *
Champion end-to-end contract management and corporate compliance, driving legal support for commercial and federal agreements while collaborating across departments to ensure efficient deal closure an...
1 week ago
Senior Strategic Alliance Manager
$210K - $253K *
Lead strategic partnerships to drive growth and success in a dynamic healthcare ecosystem. Collaborate with internal teams and external stakeholders to enhance relationships, execute activation plans...
2 days ago
$110K - $130K *
Unlock your potential as a senior Epic Willow Analyst, leading pharmacy workflow configurations and supporting clinical applications in a dynamic healthcare environment. Collaborate with teams to opti...
Yesterday
$79K - $127K *
Unlock insights into medical cost trends by leveraging data analytics. Collaborate with cross-functional teams to develop strategic recommendations, track program outcomes, and present findings clearl...
1 week ago
$108K - $162K *
Join a team that's dedicated to enhancing biomedical service operations. Lead a skilled team of technicians, ensuring high-quality support and customer satisfaction across the Pacific Northwest while...
3 weeks ago
Chief of Staff - Vice President of HIV, Hepatitis, and TB
$110K - $130K *
Join a dynamic team to drive strategic initiatives and enhance global health outcomes. Collaborate with senior leadership to synthesize complex data, manage special projects, and prepare impactful com...
Reposted 1 week ago
$95K - $115K *
Lead the implementation and management of client Speaker Bureau operations, ensuring successful educational programs in the pharmaceutical sector. Collaborate with cross-functional teams to exceed cli...
Yesterday
$110K - $130K *
Empower your career by driving strategic sales initiatives within large healthcare organizations. Own the full sales cycle, build executive relationships, and position a leading clinical collaboration...
6 days ago
Specialty Development Executive - West Territory
$140K - $180K *
Advance healthcare by driving product adoption and education in colorectal cancer screening across a key geographic territory. Collaborate with healthcare providers to enhance market penetration and e...
Reposted 2 weeks ago
Specialty Development Executive - Southeast Territory
$130K - $140K *
Empower healthcare providers by promoting innovative colorectal cancer screening solutions, delivering exceptional support and education while strategically expanding product adoption across a designa...
Reposted 2 weeks ago
Director, Quality & Health Equity
$120K - $145K *
Unlock health equity and quality improvement by leading strategic initiatives that enhance outcomes and reduce disparities across diverse populations in value-based care settings. Collaborate with sta...
2 days ago
$80K - $90K *
Champion project success by managing timelines, resources, and stakeholder communication. Drive seamless implementation experiences while collaborating with cross-functional teams to deliver value-dri...
3 weeks ago
Transitions of Care Advanced Practice Provider (NP or PA)
$120K - $150K *
Join a team that's dedicated to enhancing patient care through comprehensive post-discharge support. As an Advanced Practice Provider, you'll manage complex cases, collaborate with interdisciplinary t...
3 weeks ago
Analyst - Information Technology
$66K - $113K *
Champion enterprise portfolio reporting and analytics, developing insights to drive strategic decision-making and enhance project visibility. Collaborate across teams to create actionable dashboards a...
4 weeks ago
$80K - $110K *
Analyze and support value-based care initiatives, developing innovative forecasting solutions and methodologies. Collaborate across teams to translate complex data into actionable insights that guide...
Reposted 3 days ago
Remote Clinical Psychologist - Older Adults | PhD / PsyD | South Dakota | Telehealth
$80K - $100K *
Transform the way we deliver mental health care to older adults through evidence-based teletherapy. Join a supportive team that prioritizes your autonomy and growth while you manage personalized treat...
1 month ago
Complex Pediatric Clinical Psychologist
$80K - $95K *
Transform pediatric care by integrating psychological services within a dynamic, interdisciplinary team. Collaborate with healthcare professionals to support children and families, addressing emotiona...
4 weeks ago
$80K - $95K *
Elevate your career by managing clinical sites and ensuring study quality, patient safety, and regulatory compliance. Collaborate with site teams to support enrollment and deliver impactful clinical r...
Today
Business Development Manager - Acute
$95K - $115K *
Grow your career by driving revenue growth in the acute care market through new customer acquisition and account expansion. Manage the full sales lifecycle while collaborating with internal teams to d...
Yesterday
Senior Principal, Business Management
$135K - $160K *
Drive strategic initiatives by developing KPI frameworks and operational dashboards, analyzing performance data, and collaborating across teams to enhance business outcomes and support informed decisi...
Today
$100K - $120K *
Unlock growth potential by managing strategic accounts and cultivating executive relationships. Drive revenue through tailored strategies and consultative selling, while aligning cross-functional team...
Reposted 2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.