Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Oncologist Jobs in South Dakota

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$144K - $205K *

Elevate the quality and impact of AP Social Science courses by leading a diverse team, driving strategic initiatives, and ensuring assessment integrity. Collaborate across departments to enhance stude...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Education, Government & Non-Profit

$190K - $300K *

Manage and optimize the digital marketing strategy for oncology products, enhancing customer engagement through innovative digital assets. Lead cross-functional teams to execute comprehensive marketin...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Take ownership of key client relationships, driving growth in the renewable energy analytics sector while collaborating across teams to support long-term strategic goals and ensure client success with...

RemoteRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Energy & Utilities

$80K - $95K *

Help us deliver exceptional training and support for medical imaging equipment, enhancing customer experiences through expertise and mentorship while traveling frequently to engage with healthcare pro...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$175K - $219K *

Help us elevate Field Medical operations by optimizing processes, enhancing communication, and driving strategic initiatives to ensure effective engagement and alignment across teams in a dynamic heal...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$140K - $170K *

Shape the future of healthcare technology by leveraging your expertise to drive sales success. Collaborate with cross-functional teams to deliver tailored solutions, engage customers, and enhance prod...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Manage and optimize Epic Professional Billing workflows, focusing on Claims and Remittance. Serve as a key resource for end-users, troubleshooting issues and enhancing billing processes to ensure accu...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$210K - $225K *

Pioneer innovative research strategies to enhance clinical outcomes and drive impactful insights through collaboration across teams, while establishing a robust research infrastructure and publication...

United StatesRemote

1 month ago

  •   8 - 10 years exp.  •   Healthcare

$132K - $178K *

Champion quality in In-Vitro Diagnostics and Companion Diagnostics. Lead proactive strategies, ensuring compliance in clinical trials while collaborating with partners to enhance precision medicine in...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$90K *

Engage with healthcare professionals to drive growth in advanced wound care. Collaborate with cross-functional teams to develop strategies, expand accounts, and build strong relationships, ensuring ef...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$198K - $297K *

Engage in a dynamic role that empowers team collaboration and drives results in a leading organization recognized for innovation and excellence in performance, fostering an environment of growth and p...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $85K *

Grow your career with a dynamic team focused on client success, managing relationships, and delivering tailored solutions. Drive satisfaction and retention while collaborating across departments to en...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$72K - $120K *

Lead a multi-disciplinary team in developing machine learning algorithms to enhance clinical decision support, leveraging healthcare datasets for innovation and making vital discoveries that drive pro...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$105K - $124K *

Lead and optimize research intern activities, ensuring alignment with project goals and technical standards. Manage workflows, provide coaching, and conduct hands-on research while supporting the Dire...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$120K *

Transform mental health care by building strategic partnerships with providers to enhance access to specialized OCD treatment. Drive growth through relationship-building, education, and effective refe...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Drive regulatory strategy across major programs, leading high-impact submissions and authority engagement. Collaborate with cross-functional teams to optimize clinical development and ensure complianc...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Join our team to enhance clinical systems for medication management, focusing on optimizing workflows and supporting pharmacy operations. Collaborate with stakeholders to ensure accuracy and efficienc...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$80K - $110K *

Design and develop advanced analytics solutions, transforming complex healthcare data into actionable insights using Azure Databricks and Power BI. Collaborate with cross-functional teams to enhance r...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$250K - $300K *

Partner with us to provide expert breast imaging interpretation in a fully remote setting. Enjoy flexible scheduling and a supportive team environment while contributing to exceptional patient care ac...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$96K - $144K *

Take ownership of contract management by drafting, negotiating, and administering agreements with key customers. Collaborate with cross-functional teams to ensure compliance and operational efficiency...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Business Services

$156K - $187K *

Transform the data landscape by designing and implementing robust integration solutions. Collaborate with cross-functional teams to enhance analytics infrastructure, ensuring seamless data flow and go...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$114K - $171K *

Join a team that's driving growth in clinical trials by identifying and securing partnerships. Collaborate with cross-functional leaders to enhance visibility and expand opportunities, ensuring seamle...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$116K *

Lead site activation efforts by coordinating with cross-functional teams to ensure timely and quality delivery of clinical projects. Drive strategic initiatives and mitigate risks while enhancing comm...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Transform the clinical sales landscape by leading a regional team to drive utilization growth, enhance patient treatment metrics, and foster cross-functional collaboration for commercial success in in...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $235K *

Elevate your legal career by delivering strategic counsel and effective services to Managed Services Organizations and physician practices, while managing complex legal projects and mentoring a team i...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.