Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Triage Clinical Guide (Registered Nurse) - Care OnDemand
$85K - $110K *
Unlock better healthcare experiences by providing telephonic triage and support. As a key advocate for members, you'll connect them with essential resources, ensuring timely and appropriate care while...
Yesterday
Clinical Psychologist (Remote)
$120K - $130K *
Shape the future of mental health care by providing virtual counseling and developing treatment plans for patients with acute conditions. Collaborate with medical professionals while ensuring adherenc...
6 days ago
Remote Clinical Psychologist - Older Adults | PhD / PsyD | PSYPACT | Telehealth
$100K - $120K *
Join a team that's redefining telehealth by delivering exceptional psychotherapy to older adults. Enjoy flexible hours, comprehensive support, and opportunities for professional growth while making a...
4 weeks ago
Health Plan Partnerships Manager
$100K - $115K *
Elevate your career by driving growth and operations in health plan partnerships. This role combines sales enablement and partner operations, directly impacting revenue through strategic collaboration...
2 weeks ago
Vice President Enterprise Sales - Texas
$205K - $380K *
Accelerate progress at enterprise sales by driving strategic growth initiatives, building relationships with healthcare leaders, and leading complex sales pursuits to enhance market presence and custo...
4 weeks ago
Executive Director, Translational Medicine & Pediatric Planning
$246K - $332K *
Drive pediatric development strategy by integrating clinical insights and regulatory commitments across multiple therapeutic areas, ensuring effective execution from candidate transition to post-marke...
2 weeks ago
Solution Engineer (Billing Specialist)
$105K - $130K *
Join a team that's redefining billing solutions in the legal sector. Leverage your expertise in law firm financial operations to support sales efforts, conduct client demos, and enhance our innovative...
3 weeks ago
$150K - $200K *
Lead client engagements by leveraging tax expertise to drive revenue growth, manage complex planning discussions, and enhance client relationships while ensuring strategic alignment across teams for o...
6 days ago
Senior Director Payer Contracting
$150K - $180K *
Join us to lead payer contracting strategies, negotiate complex agreements, and enhance reimbursement performance across diverse healthcare models while managing a high-performing team in a dynamic, r...
3 weeks ago
Senior Intelligence Analyst, DPRK & China Focus
$120K - $145K *
Unlock the potential of crypto intelligence by owning in-depth analyses of DPRK and Chinese financial threats, tracing illicit networks, and producing actionable insights for stakeholders across the g...
Reposted 4 weeks ago
$150K - $180K *
Champion a transformative product vision, leading cross-functional teams to drive strategic outcomes in a dynamic digital health environment. Shape the future of patient care and client experience whi...
1 week ago
Supervising Physician - Dermatology (Remote)
$210K - $250K *
Lead the charge in providing remote clinical oversight for Dermatology PAs, ensuring high-quality patient care and compliance with regulations. Collaborate with a dedicated team to foster clinical exc...
1 week ago
Senior Advisor, Staff Well-Being and Workforce Resilience
$95K - $115K *
Transform staff well-being by leading strategic initiatives that enhance resilience and psychosocial support across diverse, high-stress environments, ensuring alignment with organizational priorities...
6 days ago
Principal Health Data Scientist
$130K - $155K *
Lead advanced analytics and statistical modeling to transform complex healthcare data into actionable insights, collaborating with cross-functional teams to solve strategic business challenges and enh...
Today
Clinical Trials Medical Writer
$77K - $92K *
Join a dynamic team as a Medical Writer, where you'll interpret complex clinical protocols and create essential documentation for clinical studies, ensuring high-quality standards and regulatory compl...
2 weeks ago
$101K - $136K *
Transform clinical documentation by crafting high-quality regulatory submissions. Collaborate with cross-functional teams to ensure compliance with FDA and ICH guidelines while managing timelines and...
4 weeks ago
Hemostasis Sales Specialist - East Texas Region
$99K - $136K *
Join a dynamic team as a strategic growth architect, driving revenue and market share expansion in the Hemostasis portfolio. Leverage your expertise in complex healthcare sales to influence decision-m...
2 weeks ago
$133K - $180K *
Join a team that's redefining member experiences by architecting optimal journeys, bridging operational execution with strategic vision to enhance engagement and satisfaction across all touchpoints...
Reposted 4 days ago
$78K - $113K *
Innovate healthcare fraud prevention by leading complex investigations, evaluating medical necessity, and collaborating with regulatory agencies to ensure quality member care and safeguard plan assets...
Today
$78K - $113K *
Unlock potential by leading complex investigations into healthcare fraud, waste, and abuse. Collaborate with regulatory agencies and internal teams to ensure compliance and safeguard member care while...
Today
Sr. Director, Integrated Evidence Generation Lead
$175K - $210K *
Lead pioneering evidence generation initiatives to inform oncology product strategies and lifecycle management through cross-functional collaboration and data-driven decision-making...
Reposted yesterday
$80K - $95K *
Drive customer success by managing key accounts in cattle genomics. Collaborate with cross-functional teams to enhance service delivery, support genomic solutions, and ensure high-quality customer exp...
3 weeks ago
Senior Engineer/Scientist- Epidemiologist
$110K - $130K *
Elevate your career by providing expert epidemiological insights into occupational exposures for military aviation and firefighter data sets, driving impactful research and analysis to enhance safety...
4 weeks ago
Senior Account Manager, Med Affairs
$90K - $105K *
Collaborate with clients and teams to manage projects, expectations, and delivery, ensuring high standards and strategic growth in a fast-paced medical affairs environment. Leverage experience to iden...
Reposted 1 week ago
$90K - $110K *
Transform healthcare delivery by leading clinical operations, ensuring high-quality patient care, and fostering collaboration across departments. Drive strategic initiatives while managing resources a...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.