Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Oncologist Jobs in South Dakota

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$245K - $265K *

Optimize partnerships with Medical Experts to enhance neurology care. Drive strategic insights and educational initiatives while collaborating across teams to influence business decisions and improve...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $190K *

Lead the charge in driving growth by managing a high-performing sales team, collaborating across functions, and executing strategic initiatives to enhance commercial success in the Hematology sector...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Join a dynamic team as a strategic partner to senior living operators, driving adoption and ROI. Leverage your clinical expertise and commercial acumen to enhance client relationships and ensure succe...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$135K - $160K *

Unlock potential by leading a dynamic sales team in hematology, driving strategic account management and fostering key stakeholder relationships to enhance the clinical experience with ZYNLONTA across...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$205K - $380K *

Engage as a strategic leader in enterprise sales, driving growth by securing key healthcare partnerships and executing market strategies. Collaborate with cross-functional teams to enhance customer va...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$186K - $233K *

Empower the future of real-world analytics by leading programming activities for observational studies, ensuring high-quality deliverables through collaboration with cross-functional teams and innovat...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$79K - $157K *

Advance clinical data insights by reviewing and analyzing trial results, collaborating with cross-functional teams to ensure data integrity, and presenting findings to stakeholders, enhancing study ou...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Manage implementation projects, ensuring clear ownership and accountability across complex customer engagements while maintaining rigorous oversight of critical paths and deliverables for timely launc...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$164K - $305K *

Join a team that's redefining account management by driving growth and retention for complex health systems. Build strategic relationships with C-suite executives and lead cross-functional teams to de...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$45K - $250K *

Transform your career by connecting healthcare professionals with meaningful roles. Join a supportive team focused on building relationships and driving results while enjoying unlimited earning potent...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Unlock client potential by driving adoption and optimizing solutions across legal accounts. Serve as a trusted advisor, ensuring clients maximize their investment in Intapp products while fostering lo...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$180K - $215K *

Transform your career by leading regional sales efforts, driving product launch success, and building high-performing teams. Collaborate cross-functionally to achieve sales goals and foster strong cus...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $135K *

Create strategic account plans and drive revenue growth by leading expansion discussions and managing a diverse portfolio of commercial accounts, ensuring alignment and collaboration with cross-functi...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Media

$100K - $122K *

Unlock potential by leading a dynamic accounting team, managing full-cycle accounting processes, ensuring compliance, and driving process improvements in a fast-paced environment. Collaborate with fin...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Champion the development of clinical operations by managing a network of providers, establishing policies, and enhancing quality programs. Collaborate with leadership to ensure operational excellence...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $140K *

Drive your sales career forward by leading strategic discovery conversations and developing enterprise accounts. Collaborate with technical teams to engage prospects, understand their security needs...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$105K - $140K *

Lead the charge in monitoring clinical study sites, ensuring data integrity and patient safety while collaborating with diverse teams to enhance study delivery and compliance with regulatory standards...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$85K - $115K *

Transform clinical trial operations by leading a high-performing team, ensuring efficient RFP reviews and testing requirements. Collaborate cross-functionally to drive business objectives and enhance...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$85K - $100K *

Empower our team by overseeing clinical trial activities, managing resources, and ensuring compliance with established procedures. Collaborate with cross-functional teams to drive operational excellen...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$155K - $185K *

Partner with us to lead high-impact projects in healthcare marketing, managing budgets and teams while ensuring creative excellence and strategic alignment. Drive client success through collaboration...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Join a dynamic team to optimize supply chain operations, ensuring efficient medication delivery from pharmacy partners to patients. Oversee systems, processes, and a team to scale operations amidst ra...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$76K - $114K *

Shape the future of healthcare by driving growth in Electrophysiology-focused Ambulatory Surgery Centers. Leverage your clinical expertise to build relationships, enhance product adoption, and ensure...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$223K - $313K *

Collaborate with a dedicated team of physicians to ensure high-quality inpatient care through clinical expertise, thorough reviews, and utilization management. Advance patient outcomes by utilizing st...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $195K *

Innovate member experience strategies by translating enterprise goals into actionable plans. Drive performance improvements in CAHPS and HOS programs through provider engagement and data analysis, ens...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$85K - $110K *

Unlock better healthcare experiences by providing telephonic triage and support. As a key advocate for members, you'll connect them with essential resources, ensuring timely and appropriate care while...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.