Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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1,000+

Oncologist Jobs in Iowa

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$113K - $188K *

Shape the future of managed care by leading contract negotiations, performance monitoring, and strategic initiatives to optimize reimbursement and enhance payer relationships across healthcare service...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Business Services

$83K - $112K *

Transform your career by leveraging your analytical skills to enhance application systems. Collaborate with teams to improve workflows, execute tests, and support mission-driven initiatives that stren...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$124K - $171K *

Champion the future of enterprise sales by driving top-down solutions into global enterprises. Leverage AI and LLM technologies to enhance client insights and foster relationships across all organizat...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$140K - $192K *

Drive demand generation and support successful launches in the Neurology Franchise by collaborating with healthcare professionals and internal teams to exceed sales objectives and enhance patient care...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$188K - $282K *

Drive the architecture for customer data integration across digital platforms, ensuring secure ingestion and transformation. Collaborate with cross-functional teams to create scalable solutions that e...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Business Services

$150K - $180K *

Transform innovative protein design through advanced AI techniques, enhancing antibody drug discovery. Collaborate across disciplines to maximize efficiency and impact, while leading research that set...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$92K - $124K *

Partner with us to enhance legal operations and implement eDiscovery processes. You'll lead customer data privacy initiatives, improving cross-functional collaboration and response strategies for comp...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$224K - $326K *

Serve as a technical leader for large customers, guiding AI cloud strategies. Connect business priorities with scalable architecture while managing executive engagements and navigating complex decisio...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$71K - $97K *

Transform patient care by guiding transitions and ensuring optimal service continuity. Leverage your nursing expertise to navigate healthcare options and advocate for patients in need of post-acute se...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$295K - $314K *

Drive strategic biostatistical leadership for clinical development programs, overseeing statistical activities, collaborating with cross-functional teams, and ensuring high-quality data analysis to su...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$160K - $192K *

Transform commercial performance by engaging healthcare providers, driving product adoption, and collaborating with cross-functional teams to ensure patient access to innovative therapies across a def...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$200K - $235K *

Unlock potential by driving scientific excellence as a strategic partner, educating healthcare professionals on Immuno-Oncology and fostering relationships that support cancer therapeutic initiatives...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$192K - $303K *

Empower innovation as you lead the strategy and development of core platform primitives, driving the future of agentic systems and ensuring product teams can rapidly create and deploy advanced agents...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$105K - $149K *

Transform complex Consumer-Directed Health implementations for major employers. Lead strategy, execution, and client engagement while serving as a subject-matter expert to ensure operational excellenc...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Unlock potential by driving client success for enterprise accounts. Lead customer engagement, ensure adoption of solutions, and collaborate effectively with teams to promote renewals, expansion, and s...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$145K - $191K *

Lead the charge in designing scalable cloud solutions that meet diverse healthcare needs, ensuring alignment with enterprise architecture and driving technology initiatives across multiple platforms t...

United StatesRemote

Reposted 1 month ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Advance client relationships and team performance as a strategic leader, overseeing captive insurance operations, driving excellence, and enhancing service delivery while managing complex engagements...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$128K - $268K *

Shape client relationships and business strategies in agribusiness. Engage with stakeholders to drive growth, manage credit quality, and deliver tailored financial solutions, ensuring performance targ...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$192K - $240K *

Unlock your potential as a Product + Design Strategist, leading ambiguous projects from concept to execution. Collaborate with cross-functional teams to create innovative, user-centered experiences an...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$130K - $160K *

Accelerate growth in telehealth by leading strategic partnerships and business development. Drive revenue through innovative solutions, executive relationships, and a deep understanding of the healthc...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$135K - $160K *

Join a dynamic team to drive telehealth sales and strategic partnerships, identifying opportunities and building relationships across the healthcare ecosystem. Own the commercial process from prospect...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$152K - $205K *

Lead the charge in architecting AI-driven solutions for enterprise clients, transforming complex data governance challenges into actionable insights. Collaborate with stakeholders to shape product evo...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$199K - $321K *

Explore a dynamic role shaping litigation and policy strategy in the pharmaceutical sector. Collaborate with senior leaders and external stakeholders to navigate complex legal landscapes, ensuring pat...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Lead the charge in managing interdisciplinary clinical research studies, ensuring compliance with GCP and regulatory requirements while driving project delivery, quality, and financial performance. Bu...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Drive impactful clinical consulting by bridging expertise in real-world data with strategic insights. Collaborate across teams to enhance health outcomes research and contribute to thought leadership...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.