Find $100K+ Professional Jobs in Ohio

Explore high-paying professional opportunities across Ohio with Ladders. Browse vetted roles with salaries of $100,000 or more in major employment centers such as Columbus, Cleveland, Cincinnati, Dayton, and Akron. Whether you’re seeking your next leadership position or a specialized role, discover openings across a range of industries and experience levels.

Explore Ohio’s Major Job Markets

Ohio’s diverse economy creates opportunities in metropolitan hubs and communities throughout the state. Search roles in Columbus, a center for business, healthcare, government, and technology; Cleveland, with opportunities in healthcare, manufacturing, finance, and professional services; and Cincinnati, known for corporate headquarters, consumer goods, logistics, and healthcare. You can also explore positions in Dayton, Akron, Toledo, and other Ohio locations.

Industries and Career Paths

Ohio employers hire experienced professionals across industries including healthcare, technology, engineering, manufacturing, finance, sales, operations, and executive leadership. Available positions and compensation vary by employer, role, location, and qualifications. Use search filters to focus on the fields and opportunities that match your career goals.

Find the Right Ohio Opportunity

Review job requirements, responsibilities, location, and compensation details to identify roles that fit your experience. Keep your profile and résumé current, set up job alerts, and check back often to find newly posted opportunities. Ladders focuses on vetted professional jobs paying $100,000 or more, helping experienced candidates explore their next career move in Ohio.

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1,000+

Jobs in Ohio

Average Salary in USD

Average Salary: $125,313

Sort By: Relevance

$103K - $154K *

Lead the commercial success of a diverse product portfolio across North America. Drive growth, customer adoption, and lifecycle management while collaborating with cross-functional teams to align stra...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Transform electrical engineering projects by ensuring compliance, conducting inspections, and collaborating with multidisciplinary teams to deliver high-quality systems that meet safety standards and...

2 days ago

  •   Less than 5 years exp.  •   Technical Services

$199K - $321K *

Explore a dynamic role shaping litigation and policy strategy in the pharmaceutical sector. Collaborate with senior leaders and external stakeholders to navigate complex legal landscapes, ensuring pat...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive your career with a pivotal role in CMC regulatory affairs, ensuring compliance for biologics and small molecules. Collaborate across teams to prepare high-quality submissions and strategies, imp...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $128K *

Empower strategic sourcing initiatives by collaborating with stakeholders to optimize purchasing strategies, manage budgets, and enhance supplier relationships, ensuring quality care while reducing co...

Ohio, USRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $125K *

Lead projects in transportation and environmental design, managing teams and client relationships to enhance community infrastructure and ensure project quality and compliance...

Reposted 2 days ago

  •   8 - 10 years exp.  •   Technical Services

$135K - $200K *

Unlock potential by advancing 3D vision research through innovative algorithms and open source applications. Collaborate with experts to tackle challenges in photogrammetry and computer vision, contri...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$88K - $105K *

Unlock potential by leading a team of tax professionals, managing complex compliance work, and delivering solutions to minimize client tax liabilities while mentoring staff in a dynamic public account...

Reposted 2 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$133K - $173K *

Lead teams to innovate and enhance robust Data & AI platforms, ensuring scalability and security. Own platform capabilities, drive strategic decisions, and mentor engineers to unlock impactful outcome...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $130K *

Elevate your career by leading the design and implementation of complex software solutions. Collaborate with cross-functional teams to drive technical decisions and mentor engineers, ensuring scalable...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$104K - $174K *

Champion ecosystem growth by collaborating across teams to enhance partner operations, drive strategic initiatives, and optimize performance metrics, ensuring value delivery to customers and stakehold...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$95K - $115K *

Join a team that's driving integration data migration strategies and analysis. Collaborate with project teams to execute and support data governance initiatives, ensuring quality and efficiency across...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$210K - $230K *

Accelerate progress at the forefront of clinical supply chain management, leading strategic initiatives to ensure seamless delivery of investigational products for global trials while collaborating ac...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$180K - $220K *

Drive the enterprise data strategy and governance, ensuring data quality, compliance, and accessibility. Lead cross-functional teams to foster a data-rich culture, enabling advanced analytics and AI r...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Healthcare

$129K - $168K *

Drive strategic financial and operational leadership for a complex pediatric radiology department, overseeing budgeting, revenue cycle management, and clinical operations across multiple sites to ensu...

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Drive the enterprise ownership of Microsoft 365 services, ensuring optimal performance, security, and compliance. Collaborate with IT teams and external partners to enhance collaboration tools and sup...

Reposted 2 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$73K - $102K *

Champion ERP solutions by collaborating with stakeholders to customize and integrate systems, ensuring alignment with business goals. Drive enhancements and maintain compliance while delivering effect...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$81K - $137K *

Unlock financial insights by leading complex accounting operations, ensuring accuracy in reporting, and collaborating with cross-functional teams to enhance processes and drive business decisions in a...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$160K - $190K *

Unlock your potential as you lead end-to-end design for complex AI-driven systems. Collaborate with cross-functional teams to create intuitive, secure user experiences that prioritize trust and precis...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Information Technology

$184K - $356K *

Innovate at the forefront of AI infrastructure validation by designing and implementing robust tooling for cluster readiness and certification, ensuring optimal performance for GPU deployments in prod...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$70K - $96K *

Empower your career by joining our dynamic team to drive client engagement, identify opportunities, and develop innovative sales strategies. Collaborate with stakeholders and enhance your skills in a...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Transform healthcare initiatives by leading projects from inception to completion. Coordinate teams, manage timelines, and ensure clear communication to drive organizational priorities and deliver mea...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$170K - $195K *

Lead the charge in powering global initiatives by overseeing operations support, ensuring compliance, and implementing best practices across a vast energy portfolio to drive performance and safety in...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$204K - $254K *

Drive customer success by leveraging technical expertise to engage, educate, and empower clients. Collaborate with sales to articulate value propositions and enhance product offerings in a dynamic, re...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$90K - $110K *

Champion individualized psychiatric care by conducting assessments, managing medications, and collaborating with a multidisciplinary team to enhance client outcomes across diverse age groups and needs...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Ohio?question toggle

    Ohio listings may include professional, management, executive, and specialized positions in fields such as healthcare, technology, engineering, manufacturing, finance, sales, and operations. Roles and salaries vary by employer and qualifications.

  • Which Ohio cities have high-paying job opportunities?question toggle

    Opportunities may be available in Columbus, Cleveland, Cincinnati, Dayton, Akron, Toledo, and other Ohio communities. Availability changes as employers post and fill positions.

  • Are the Ohio jobs on Ladders vetted?question toggle

    Ladders focuses on vetted professional job opportunities with salaries of $100,000 or more. Review each listing for its specific compensation and requirements.

  • How can I find a suitable job in Ohio?question toggle

    Search by location, job title, industry, or other relevant filters. Compare the qualifications, responsibilities, location, and compensation listed for each role, and keep your résumé and profile up to date.