Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.
North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.
Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.
Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.
Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.
Average Salary: $114,788
Distinguished Engineer, Frontier Agentic AI (Remote)
$235K - $350K *
Empower the future of cybersecurity AI by leading innovative research and development. Collaborate with experts to create advanced systems that enhance defense capabilities and transform security oper...
1 week ago
Staff Product Marketing Manager, Cloud Risk & Developer Security (Remote)
$145K - $220K *
Drive impactful product marketing strategies for proactive security solutions, guiding market positioning, launches, and customer engagement. Collaborate with cross-functional teams to shape product d...
1 week ago
Executive Director, Corporate Real Estate Services
$160K - $200K *
Oversee global real estate strategy for a multinational organization, optimizing a diverse portfolio across 50+ countries. Drive cost efficiency, workplace transformation, and operational excellence w...
1 week ago
Senior Regulatory Strategist, Advertising & Promotion (work from home)
$120K - $145K *
Empower regulatory excellence by guiding cross-functional teams in compliance and strategy. Leverage deep FDA knowledge to influence promotional materials and ensure adherence to evolving regulations...
1 week ago
Regulatory Strategy Consultant
$125K - $150K *
Drive regulatory strategy across major programs, leading high-impact submissions and authority engagement. Collaborate with cross-functional teams to optimize clinical development and ensure complianc...
1 week ago
Senior / Global Regulatory Labeling Strategist
$125K - $150K *
Champion global labeling strategy for innovative therapies, leading complex initiatives from development to post-approval. Collaborate with cross-functional teams to ensure compliance and high-quality...
1 week ago
Country Study Manager - FSP - East Coast
$110K - $130K *
Join a team that's dedicated to advancing clinical research through comprehensive trial management, vendor oversight, and strategic operations, ensuring successful delivery of studies from initiation...
Reposted 1 week ago
Senior Regulatory Affairs Associate - CTA Senior Specialist
$110K - $130K *
Join a team that's advancing global health by supporting critical clinical trial submissions. In this role, you'll lead regulatory strategies, ensure compliance, and collaborate with diverse teams to...
1 week ago
Senior Consulting Engineer Physical Security
$107K - $150K *
Engage with clients to design and implement advanced Physical Security Systems. Collaborate with top engineers on complex projects, ensuring high-quality solutions and customer satisfaction while mana...
1 week ago
$80K - $95K *
Drive purchasing excellence and strategic alignment by managing supplier portfolios, negotiating optimal contracts, and ensuring timely delivery of materials to support operational success...
Reposted 1 week ago
Mechanical Engineer Specialist - Structural Analysis (Nuclear)
$95K - $115K *
Join a team that's dedicated to advancing nuclear engineering solutions. Leverage your expertise in structural analysis to enhance product performance and ensure compliance with industry standards whi...
1 week ago
Director, Medical Digital Solutions
$192K - $252K *
Champion digital transformation by optimizing medical technology solutions and enhancing HCP engagement strategies. Drive adoption and value realization of innovative tools across Field Medical teams...
1 week ago
Sr. Principal Software and AI Engineer
$137K - $182K *
Architect and drive AI-powered applications for drug development, focusing on protocol generation and clinical trials. Lead technical direction, mentor engineers, and ensure compliance while fostering...
1 week ago
New Product Development Program Manager
$123K - $169K *
Drive your career with end-to-end management of new product development programs, ensuring alignment across teams and delivering innovative solutions for critical digital infrastructure in a dynamic e...
1 week ago
Global Product Line Manager - Modular
$176K - $243K *
Drive product portfolio expansion for Modular Datacenter Infrastructure, ensuring market leadership through strategic planning, P&L management, and fostering innovation. Lead a diverse team to enhance...
1 week ago
Sr. Manager, Real Estate, Tim Hortons, US
$110K - $130K *
Join a team that's shaping the future of restaurant development by partnering with franchisees to identify, secure, and build new locations. Drive growth through strategic site evaluations, negotiatio...
1 week ago
$130K - $190K *
Empower veterinary professionals by delivering expert dermatology advice and support, enhancing case management, and fostering strong relationships. Join a dynamic team committed to advancing veterina...
Reposted 1 week ago
Senior Director, Global ERP Delivery & Solution Architecture
$151K - $314K *
Shape the future of global ERP delivery by leading a diverse team, executing strategic initiatives, and driving transformation across multiple regions to enhance operational efficiency and business va...
1 week ago
Professional (Senior) Sales Representative, Respiratory – Southern IL
$100K - $162K *
Drive sales success in the Southern IL territory by developing strategic business plans, conducting impactful presentations, and fostering strong relationships with healthcare professionals to achieve...
1 week ago
Professional (Senior) Sales Representative, Respiratory – The Woodlands, TX
$100K - $162K *
Drive success by developing strategic sales plans and fostering relationships in your territory. Achieve sales goals through effective presentations and ethical practices while continuously enhancing...
1 week ago
Professional (Senior) Sales Representative, Respiratory – Tulsa, OK
$100K - $162K *
Drive sales growth in assigned territory by developing strategic plans, conducting impactful presentations, and fostering strong relationships with healthcare professionals while adhering to ethical p...
1 week ago
Product Development - US Wealth Private Assets
$110K - $130K *
Accelerate progress at the forefront of Private Asset product development, driving innovative solutions and collaboration across teams to enhance US Wealth offerings and ensure market relevance throug...
1 week ago
Director, Threat Detection & Response
$175K - $235K *
Accelerate progress at the forefront of cybersecurity by leading incident response, detection engineering, and threat hunting teams. Drive strategy and build capabilities to protect critical payment p...
1 week ago
$120K - $145K *
Lead the design and implementation of enterprise-scale cloud security controls, ensuring operational readiness and compliance. Mentor engineers, influence best practices, and drive technical standards...
1 week ago
$95K - $115K *
Drive the future of fraud prevention by shaping strategies and optimizing real-time decisioning platforms. Collaborate cross-functionally to enhance detection effectiveness and ensure compliance with...
1 week ago
What types of $100K+ jobs can I find in North Carolina?
North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.
Which North Carolina cities have professional job opportunities?
You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.
Are the jobs on this page vetted?
Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.
How can I find a specific type of job in North Carolina?
Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.
Do all North Carolina jobs on Ladders pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.