Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.
North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.
Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.
Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.
Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.
Average Salary: $114,657
$115K - $156K *
Join a team that's dedicated to advancing drug substance production through engineering excellence. As a key member, you'll design, commission, and maintain essential clean utility systems, ensuring o...
Reposted 1 week ago
Field Reimbursement Manager - Michigan
$185K - $230K *
Unlock potential by developing strategic access plans for community healthcare, ensuring streamlined reimbursement processes and compliance while collaborating with stakeholders to enhance patient acc...
1 week ago
Staff Technical Product Manager
$198K - $233K *
Architect the roadmap for our Business Technology Services and Workato platform, driving integration and automation across systems. Collaborate with stakeholders to prioritize demands, ensuring scalab...
Reposted 1 week ago
Staff Engineer, Technical Lead, Content Management Systems
$198K - $233K *
Lead the charge in developing a robust content management system to enhance cross-functional workflows and publishing capabilities, fostering a high-performing engineering team dedicated to scalabilit...
Reposted 1 week ago
Deputy General Services Director
$122K - $190K *
Join a team that's shaping the future of city facilities management. Lead strategic initiatives, oversee capital projects, and enhance service delivery across 400+ properties while collaborating with...
1 week ago
$110K - $130K *
Join a team that’s driving growth and delivering security solutions to major accounts. You’ll build strong executive relationships, shape multi-year strategies, and lead complex sales processes in a d...
Reposted 1 week ago
$110K - $130K *
Accelerate your career by leading cross-functional programs that drive strategic initiatives in healthcare and biotechnology. Leverage your expertise to enhance product development, compliance, and op...
1 week ago
$110K - $130K *
Drive growth by shaping strategic account plans and leading complex deals. Build executive relationships and manage a focused portfolio of customers, ensuring security during their digital transformat...
1 week ago
$80K - $95K *
Empower the clinical support team by coordinating complex cases, mentoring junior counselors, and enhancing protocols. Your expertise will drive effective communication and quality standards in geneti...
1 week ago
Frontline Operations Supervisor-Nights
$88K - $122K *
Lead the charge in optimizing night shift operations, overseeing a team of 30-45 associates. Drive production efficiency, safety, and team development while exploring growth opportunities across vario...
1 week ago
$171K - $269K *
Lead the charge in defining and evolving data architecture and engineering standards for scalable, secure enterprise data platforms. Collaborate across teams to deliver reliable, actionable data produ...
1 week ago
Mortgage Forward Deployed Engineer
$150K - $170K *
Join us to bridge technology and clients in the mortgage industry. You'll engage directly with customers, develop solutions, and influence product direction while driving efficiency and innovation in...
1 week ago
National Manager, Oncology Nurse Educator Field Strategy & Execution
$130K - $155K *
Drive strategic nursing initiatives across oncology franchises, ensuring effective execution of portfolio strategies. Collaborate with cross-functional teams to optimize resources and enhance field pe...
1 week ago
National Manager, Oncology Nurse Educator Field Strategy & Execution
$120K - $145K *
Shape the future of oncology nursing by driving strategic education initiatives, optimizing field operations, and fostering cross-functional collaboration to enhance performance and compliance across...
1 week ago
Director, People Business Partner - Product, Technology & AI
$150K - $180K *
Transform the future of talent management by partnering with Product and Technology leaders to design and implement a GM operating model, ensuring effective organizational strategies and people practi...
1 week ago
Regional Director, Clinical & Regulatory Support, Post Acute Services
$110K - $130K *
Lead initiatives to enhance clinical services in post-acute care, driving quality improvements and operational efficiency while collaborating with multidisciplinary teams to ensure optimal patient out...
1 week ago
Manager-Vendor Relations (Full-time Hybrid, Morrisville, North Carolina Based)
$77K - $99K *
Transform vendor relationships and drive operational excellence in management, negotiation, and performance monitoring for vendor contracts. This role requires strategic collaboration across departmen...
Reposted 1 week ago
$120K - $140K *
Architect AI-driven solutions to enhance GTM operations, streamline workflows, and empower sales and support teams. Collaborate cross-functionally to automate processes, improve efficiency, and drive...
1 week ago
Artificial Intelligence Quality Engineer (Full-time Hybrid, Morrisville, NC Based)
$107K - $137K *
Empower the future of AI by ensuring the reliability and safety of innovative solutions. Collaborate with cross-functional teams to design evaluation frameworks and optimize AI models, driving quality...
Reposted 1 week ago
Director, Solutions Engineering
$170K - $185K *
Champion technical sales execution across diverse domains, driving alignment with growth priorities. Lead a high-performing team, enhance customer outcomes, and provide strategic insights to elevate s...
1 week ago
Director, Solutions Engineering
$170K - $185K *
Lead the charge in driving technical sales execution across multiple domains, enhancing team performance, aligning strategies with regional growth, and improving customer outcomes through effective re...
1 week ago
$200K - $230K *
Unlock the potential of innovative products by partnering with technical teams to design and deliver exceptional customer experiences in a dynamic, regulated environment. Your expertise will shape com...
Reposted 1 week ago
$88K - $105K *
Engage in maintaining and troubleshooting factory machinery and control systems, ensuring operational efficiency and safety. Collaborate with teams to implement preventive maintenance and improvement...
1 week ago
Neuro ICU Advanced Practice Provider (Nocturnal)
$100K - $120K *
Join a dedicated team providing critical care for neuro patients in a dynamic ICU environment. Collaborate with multidisciplinary professionals to enhance patient outcomes and implement evidence-based...
1 week ago
$56K - $125K *
Lead store operations by enhancing sales and customer experience while managing team performance and inventory. Drive profitability through effective merchandising and compliance with regulations, ens...
1 week ago
What types of $100K+ jobs can I find in North Carolina?
North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.
Which North Carolina cities have professional job opportunities?
You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.
Are the jobs on this page vetted?
Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.
How can I find a specific type of job in North Carolina?
Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.
Do all North Carolina jobs on Ladders pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.