Explore $100K+ Jobs in North Carolina

Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.

Professional Opportunities Across the State

North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.

Explore North Carolina's Major Job Markets

Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.

Find a Role That Fits Your Experience

Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.

Advance Your Career in North Carolina

Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.

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1,000+

Jobs in North Carolina

Average Salary in USD

Average Salary: $114,657

Sort By: Relevance

$115K - $156K *

Join a team that's dedicated to advancing drug substance production through engineering excellence. As a key member, you'll design, commission, and maintain essential clean utility systems, ensuring o...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$185K - $230K *

Unlock potential by developing strategic access plans for community healthcare, ensuring streamlined reimbursement processes and compliance while collaborating with stakeholders to enhance patient acc...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$198K - $233K *

Architect the roadmap for our Business Technology Services and Workato platform, driving integration and automation across systems. Collaborate with stakeholders to prioritize demands, ensuring scalab...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$198K - $233K *

Lead the charge in developing a robust content management system to enhance cross-functional workflows and publishing capabilities, fostering a high-performing engineering team dedicated to scalabilit...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$122K - $190K *

Join a team that's shaping the future of city facilities management. Lead strategic initiatives, oversee capital projects, and enhance service delivery across 400+ properties while collaborating with...

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Join a team that’s driving growth and delivering security solutions to major accounts. You’ll build strong executive relationships, shape multi-year strategies, and lead complex sales processes in a d...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Accelerate your career by leading cross-functional programs that drive strategic initiatives in healthcare and biotechnology. Leverage your expertise to enhance product development, compliance, and op...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Drive growth by shaping strategic account plans and leading complex deals. Build executive relationships and manage a focused portfolio of customers, ensuring security during their digital transformat...

Raleigh, NCRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Empower the clinical support team by coordinating complex cases, mentoring junior counselors, and enhancing protocols. Your expertise will drive effective communication and quality standards in geneti...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$88K - $122K *

Lead the charge in optimizing night shift operations, overseeing a team of 30-45 associates. Drive production efficiency, safety, and team development while exploring growth opportunities across vario...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$171K - $269K *

Lead the charge in defining and evolving data architecture and engineering standards for scalable, secure enterprise data platforms. Collaborate across teams to deliver reliable, actionable data produ...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $170K *

Join us to bridge technology and clients in the mortgage industry. You'll engage directly with customers, develop solutions, and influence product direction while driving efficiency and innovation in...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$130K - $155K *

Drive strategic nursing initiatives across oncology franchises, ensuring effective execution of portfolio strategies. Collaborate with cross-functional teams to optimize resources and enhance field pe...

Charlotte, NCRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Shape the future of oncology nursing by driving strategic education initiatives, optimizing field operations, and fostering cross-functional collaboration to enhance performance and compliance across...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Transform the future of talent management by partnering with Product and Technology leaders to design and implement a GM operating model, ensuring effective organizational strategies and people practi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Lead initiatives to enhance clinical services in post-acute care, driving quality improvements and operational efficiency while collaborating with multidisciplinary teams to ensure optimal patient out...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$77K - $99K *

Transform vendor relationships and drive operational excellence in management, negotiation, and performance monitoring for vendor contracts. This role requires strategic collaboration across departmen...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$120K - $140K *

Architect AI-driven solutions to enhance GTM operations, streamline workflows, and empower sales and support teams. Collaborate cross-functionally to automate processes, improve efficiency, and drive...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$107K - $137K *

Empower the future of AI by ensuring the reliability and safety of innovative solutions. Collaborate with cross-functional teams to design evaluation frameworks and optimize AI models, driving quality...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$170K - $185K *

Champion technical sales execution across diverse domains, driving alignment with growth priorities. Lead a high-performing team, enhance customer outcomes, and provide strategic insights to elevate s...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$170K - $185K *

Lead the charge in driving technical sales execution across multiple domains, enhancing team performance, aligning strategies with regional growth, and improving customer outcomes through effective re...

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$200K - $230K *

Unlock the potential of innovative products by partnering with technical teams to design and deliver exceptional customer experiences in a dynamic, regulated environment. Your expertise will shape com...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$88K - $105K *

Engage in maintaining and troubleshooting factory machinery and control systems, ensuring operational efficiency and safety. Collaborate with teams to implement preventive maintenance and improvement...

1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$100K - $120K *

Join a dedicated team providing critical care for neuro patients in a dynamic ICU environment. Collaborate with multidisciplinary professionals to enhance patient outcomes and implement evidence-based...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$56K - $125K *

Lead store operations by enhancing sales and customer experience while managing team performance and inventory. Drive profitability through effective merchandising and compliance with regulations, ens...

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

Frequently Asked Questions (FAQ)

  • What types of $100K+ jobs can I find in North Carolina?question toggle

    North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.

  • Which North Carolina cities have professional job opportunities?question toggle

    You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.

  • Are the jobs on this page vetted?question toggle

    Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.

  • How can I find a specific type of job in North Carolina?question toggle

    Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.

  • Do all North Carolina jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.