Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.
North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.
Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.
Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.
Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.
Average Salary: $114,657
Registered Nurse Care Manger - Juneau Cty
$71K - $97K *
Join a dedicated team as you support members in care coordination, focusing on health needs, education, and lifestyle modifications while managing records and completing assessments remotely. Enjoy a...
Reposted 1 week ago
$110K - $130K *
Transform engineering leadership by mentoring a skilled team, ensuring compliance with design standards, and overseeing high-quality transmission projects while fostering client relationships and prom...
Reposted 1 week ago
Professional Services Program Manager
$95K - $115K *
Champion the execution of a large-scale enterprise implementation program, ensuring alignment across multiple teams and locations. Drive stakeholder engagement, track milestones, and maintain momentum...
1 week ago
Project Engineer IV - Substation
$95K - $115K *
Lead a team of engineers in substation design projects, managing design layouts, customer relations, and business development while ensuring project quality and safety standards are met...
Reposted 1 week ago
$134K - $265K *
Join our team to lead client engagements in private markets operations, driving operational excellence and risk management. Collaborate across teams to enhance efficiency and compliance while mentorin...
1 week ago
Glaucoma Pharmaceutical Sales Specialist (Charlotte-Western NC)
$95K - $115K *
Join a team that's transforming ocular health by building relationships with eye care professionals. Drive product adoption and territory growth through strategic account management and consultative s...
1 week ago
Lead Applied Scientist, Document Understanding
$147K - $274K *
Develop advanced document understanding systems to enhance legal content processing. Collaborate across teams to design, deploy, and evaluate models that drive measurable impact in legal, tax, and acc...
1 week ago
Senior Software Engineer- Rust / C++
$94K - $176K *
Drive innovation in document processing by leading high-impact projects, shaping architecture, and optimizing performance in a queue-driven pipeline. Collaborate across teams to enhance AI products an...
1 week ago
$100K - $185K *
Elevate the legal landscape by leveraging AI to transform workflows. Collaborate with law firms to design and implement innovative solutions, ensuring successful adoption of advanced legal technologie...
1 week ago
Senior Principal Implementation Consultant
$100K - $185K *
Empower clients by leveraging deep ONESOURCE Direct Tax expertise to design innovative solutions using AI and automation tools. Engage directly with customers, manage projects, and drive efficiency wh...
1 week ago
Director, AI Specialty Sales - Small Law
$255K - $474K *
Lead AI revenue growth by driving strategy and execution across sales, partnerships, and customer success. Build and manage a high-performing team to enhance AI adoption and market share in the legal...
1 week ago
$100K - $185K *
Reimagine legal workflows as an AI Solutions Architect, driving AI adoption in law firms. Collaborate with teams to design and implement innovative solutions, enhancing efficiency and client advocacy...
1 week ago
Customer Success Manager - Global Trade
$106K - $197K *
Join a team that's dedicated to empowering customers in global trade. As a Customer Success Manager, you'll leverage your expertise to drive client success, foster relationships, and ensure optimal va...
1 week ago
Senior Medical Economics Analyst
$89K - $107K *
Join a team that's transforming healthcare through data-driven insights. As a Senior Medical Economics Analyst, you'll lead analytics initiatives, mentor a team, and collaborate with leaders to enhanc...
1 week ago
$230K - $345K *
Join a dynamic team as a Senior Manager, leading Account Executives to drive new business growth, enhance market presence, and foster a high-performance sales culture focused on accountability and cus...
1 week ago
Specification Consultant - Minnesota, North Dakota or South Dakota
$75K - $115K *
Design and deliver expert door hardware specifications for architectural projects, ensuring compliance and effective communication with stakeholders. Play a key role in enhancing market penetration th...
1 week ago
$110K - $135K *
Unlock excellence in PCB design and manufacturing by leading DFM initiatives, developing complex multilayer layouts, and shaping best practices across engineering teams to enhance product performance...
1 week ago
$92K - $140K *
Lead the charge in conducting on-site evaluations for niche-market policyholders, developing tailored strategies to mitigate risks, and providing expert consultation across all coverage lines while fo...
1 week ago
$100K - $122K *
Take ownership of financial planning and analysis for G&A expenses, driving insights and reporting for senior leadership. Collaborate with teams to enhance budgeting, forecasting, and variance analysi...
1 week ago
$88K - $105K *
Help us craft compelling proposals by leading strategic responses to client RFPs. Collaborate with cross-functional teams to deliver customized solutions, ensuring competitive edge and excellence in p...
1 week ago
Director, Quantitative Systems Pharmacology
$188K - $313K *
Lead the charge in advancing quantitative systems pharmacology through innovative modeling and simulation strategies, driving integration across drug discovery and development to enhance patient outco...
1 week ago
Associate Director, Pipeline Project Management for BD
$139K - $232K *
Champion cross-functional project management to drive R&D initiatives from diligence to integration. Collaborate with stakeholders to ensure timely execution and value realization in drug development...
1 week ago
Manager, Medical Insights (Oncology)
$110K - $130K *
Join a team that's dedicated to transforming oncology insights into actionable strategies. Collaborate with cross-functional stakeholders to synthesize complex data, driving impactful decisions that e...
1 week ago
Director, US Real-World Evidence and Health Outcome Research
$150K - $180K *
Lead the charge in real-world evidence generation for oncology hematology, driving strategic alignment across teams and managing high-priority studies to support new indication launches and enhance pa...
1 week ago
$95K - $115K *
Champion innovative omnichannel marketing strategies to engage healthcare professionals. Collaborate with cross-functional teams to execute campaigns, optimize performance, and ensure compliance, driv...
1 week ago
What types of $100K+ jobs can I find in North Carolina?
North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.
Which North Carolina cities have professional job opportunities?
You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.
Are the jobs on this page vetted?
Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.
How can I find a specific type of job in North Carolina?
Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.
Do all North Carolina jobs on Ladders pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.