Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$280K - $406K *

Join us to lead transformative finance initiatives in the utilities sector, advising top executives on FERC accounting and regulatory compliance while driving operational excellence and mentoring high...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Information Technology

$140K - $215K *

Lead the charge in driving growth by managing a cross-functional engineering team focused on optimizing subscription platforms. Foster collaboration, enhance product strategies, and ensure technical r...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$80K - $95K *

Lead the charge in optimizing branch operations by coaching teams, driving engagement, and fostering a culture aligned with company values. Utilize data-driven strategies to enhance performance and cu...

2 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$100K - $120K *

Explore a dynamic role focused on building relationships with enterprise brands, driving business growth through strategic partnerships, and leveraging AI technologies to optimize processes. Engage in...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$125K - $250K *

Champion customer success by leading presales engagements, leveraging deep expertise in simulation software and manufacturing processes to drive new business and enhance existing relationships through...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Business Services

$227K - $341K *

Oversee enterprise transformation initiatives, driving strategic planning, vendor management, and operational excellence. Lead cross-functional teams to enhance performance, implement technology solut...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$115K - $165K *

Transform your career by leading Red Team activities to assess and enhance security defenses. Collaborate with senior leadership, execute assessments, and provide strategic recommendations to safeguar...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $105K *

Champion innovative veterinary diagnostic solutions by building strong customer relationships, managing your territory, and driving sales growth through consultative techniques and education in a coll...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$265K - $300K *

Shape the future of healthcare technology by leading architectural direction and driving high-impact solutions across teams. Collaborate closely with engineering, product, and design to enhance our AI...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Healthcare

$110K - $130K *

Empower cross-functional teams to innovate and enhance platform capabilities, ensuring alignment with client needs and regulatory standards. Drive product vision from inception to adoption, leveraging...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in maximizing product value by defining vision and backlog. Bridge business needs and technical delivery, guiding products through their lifecycle to ensure alignment with strategy, re...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Healthcare

$106K - $284K *

Drive innovation by leading the design and development of scalable software solutions, mentoring engineers, and collaborating with cross-functional teams to enhance patient care and clinical technolog...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$130K - $216K *

Redefine data governance by leading teams to implement sustainable AI solutions while managing client relationships and driving collaboration across various stakeholders for impactful results...

RemoteRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Business Services

$135K - $176K *

Grow your career by leading a pharmacy team dedicated to exceptional patient care. Drive best practices, enhance team performance, and ensure compliance while fostering a culture of safety and inclusi...

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$135K - $176K *

Lead the charge in transforming patient care by managing a dedicated pharmacy team, ensuring compliance, and fostering a culture of excellence while delivering exceptional service and support to patie...

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $150K *

Transform financial operations by leading a dynamic team, ensuring accurate reporting, and driving strategic decisions that enhance value and growth in a fast-paced healthcare environment. Partner clo...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Reimagine project delivery by leading design teams and managing processes to ensure successful outcomes. Collaborate with stakeholders to create innovative solutions while maintaining compliance and q...

2 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$110K - $130K *

Lead the development of our observability practice, creating dashboards and alerting systems to ensure uptime and reliability across enterprise tools. Build visibility from scratch, automate processes...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$87K - $110K *

Contribute to impactful education research by designing and conducting rigorous quantitative studies, synthesizing evidence, and translating findings into actionable insights for policy and practice...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Unlock potential by leading innovative product development for sauces and dips, utilizing scientific principles to enhance formulations and collaborate with cross-functional teams, ensuring quality an...

2 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$86K - $132K *

Champion the assessment and evaluation of individuals in a specialized program, conducting comprehensive reviews and reports while collaborating with legal and clinical teams to ensure effective treat...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Join a team that's shaping the future of transportation engineering. In this supervisory role, you'll provide expertise, develop policies, and ensure quality assurance for critical projects, all while...

2 days ago

  •   8 - 10 years exp.  •   Transportation

$80K - $95K *

Lead the charge in forensic psychology by conducting comprehensive evaluations for court-ordered cases. Collaborate with a diverse population while gaining mentorship for certification and board crede...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Lead the charge in new business development, leveraging multi-channel outreach to book quality meetings with target companies, while collaborating with a growth team to optimize your strategies and in...

RemoteRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$95K - $115K *

Drive exceptional patient care by delivering health services as a Nurse Practitioner, collaborating with physicians and healthcare teams to enhance treatment outcomes and uphold the practice's mission...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.