Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $116,335

Sort By: Relevance

$166K - $244K *

Lead the Oncology narrative and media strategy, driving impactful communications across channels. Collaborate with cross-functional teams to enhance brand presence and storytelling, ensuring alignment...

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  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Elevate the effectiveness of product vulnerability management by owning processes, driving automation, and collaborating closely with engineering. Be the key point of accountability for reducing risk...

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  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Join a team that's dedicated to solving complex software challenges. As a Sr. Software Engineer, you'll design, build, and maintain robust applications while collaborating across teams to enhance our...

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Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Join a team that's redefining the future by leveraging cutting-edge AI to develop innovative machine learning solutions that solve complex business challenges, and actively collaborating across multid...

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Reposted today

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Engage with cross-functional teams to shape and deliver innovative classroom experiences. Take ownership of user-facing features and backend services, ensuring alignment with market needs and enhancin...

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Reposted today

  •   5 - 7 years exp.  •   Food & Beverages

$143K - $194K *

Elevate software development by designing and deploying distributed open-source message broker systems. Collaborate with cross-functional teams to drive architecture and best practices while mentoring...

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  •   Less than 5 years exp.  •   Retail & Consumer Goods

$95K - $115K *

Join us to design and deliver innovative mechanical systems for heavy industrial thermal processes. Collaborate with cross-functional teams, mentor junior engineers, and tackle complex challenges in a...

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  •   5 - 7 years exp.  •   Manufacturing & Automotive

$230K - $260K *

Lead the charge in client migrations, owning the entire technical lifecycle from legacy analysis to deployment, ensuring precision and collaboration across teams for optimal outcomes...

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Reposted today

  •   8 - 10 years exp.  •   Information Technology

$59K - $110K *

Engage with patients and caregivers to enhance their treatment journey through education and support. Collaborate with teams to ensure quality service and compliance while driving innovative solutions...

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  •   Less than 5 years exp.  •   Business Services

$58K - $108K *

Join a team that's dedicated to enhancing patient experiences through compassionate support and education in Hepatology. Engage with patients and caregivers, providing vital resources and guidance thr...

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  •   Less than 5 years exp.  •   Business Services

$105K - $135K *

Lead financial planning and analysis efforts, partnering with business leaders to drive strategic insights, enhance decision-making, and improve operational excellence through data-driven financial mo...

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  •   5 - 7 years exp.  •   Consumer Technology

$96K - $115K *

Lead the charge in designing and developing aerospace wire harnesses, ensuring compliance with industry standards while collaborating with multidisciplinary teams to deliver innovative solutions...

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Reposted today

  •   Less than 5 years exp.  •   Aerospace & Defense

$114K - $218K *

Transform the construction industry by leveraging geospatial technology to enhance customer relationships and optimize strategies for growth. Collaborate with experts and use your industry insights to...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Information Technology

$97K - $162K *

Innovate backend solutions for critical national security missions, developing APIs and data capabilities in cloud environments. Collaborate with Defense and Intelligence sectors to solve complex tech...

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$150K - $160K *

Partner with us to shape the quality strategy for a leading exam development platform. Leverage your expertise to guide multiple Agile teams, enhance automation practices, and ensure high standards ac...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$90K - $110K *

Optimize product operations by driving launches, enhancing documentation, and improving customer experiences. Collaborate with cross-functional teams to ensure seamless feature adoption and leverage c...

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  •   Less than 5 years exp.  •   Media

$187K - $243K *

Engage in building and scaling systems that serve millions. As a seasoned engineer, influence technical decisions, foster AI adoption, and lead projects from concept to deployment while collaborating...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Consumer Technology

$91K - $178K *

Unlock seamless integration across complex systems by architecting and developing SAP solutions. Lead a team in delivering high-quality technical documentation and best practices while ensuring compli...

Reposted today

  •   5 - 7 years exp.  •   Business Services

$95K - $115K *

Elevate your career by owning IT operations, enhancing security, and automating workflows in a fully remote environment. Collaborate with teams to resolve complex issues and streamline processes while...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

$133K - $200K *

Champion the delivery of advanced manufacturing capabilities by leading cross-functional teams, managing project lifecycles, and ensuring alignment with customer and stakeholder expectations for succe...

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  •   8 - 10 years exp.  •   Business Services

$110K - $135K *

Join us in shaping innovative partner programs aimed at enhancing legal collaboration. This strategic role demands creativity and leadership, managing bar association relations to propel growth and su...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Legal & Accounting

$120K - $145K *

Empower your career by leading data architecture initiatives across Oracle Cloud applications. Drive data governance, migration, and integration strategies to enhance business processes and ensure dat...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Staffing

$110K - $130K *

Unlock potential by driving research in prediction markets, developing alpha signals, and collaborating through the entire model implementation process. Guide projects from data analysis to live tradi...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Finance & Insurance

$132K - $194K *

Unlock potential by leading the strategy and evolution of People technology and analytics. Drive data governance and insights to enhance decision-making and operational efficiency, while partnering wi...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Information Technology

$75K - $90K *

Drive impactful SEM strategies to enhance online visibility and conversions. Collaborate with diverse clients, analyze data, and optimize campaigns to exceed goals while staying ahead of industry tren...

United StatesRemote

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  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.